المؤلفون: Bronisz-Budzyńska, Iwona, Kozakowska, Magdalena, Podkalicka, Paulina, Kachamakova-Trojanowska, Neli, Łoboda, Agnieszka, Dulak, Józef

المساهمون: Narodowe Centrum Nauki, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University

المصدر: Skeletal Muscle ; volume 10, issue 1 ; ISSN 2044-5040

مصطلحات موضوعية: Cell Biology, Molecular Biology, Orthopedics and Sports Medicine

الوصف: The nuclear factor erythroid 2-related factor 2 (Nrf2) is considered as a master cytoprotective factor regulating the expression of genes encoding anti-oxidant, anti-inflammatory, and detoxifying proteins. The role of Nrf2 in the pathophysiology of skeletal muscles has been evaluated in different experimental models, however, due to inconsistent data, we aimed to investigate how Nrf2 transcriptional deficiency (Nrf2 tKO ) affects muscle functions both in an acute and chronic injury. The acute muscle damage was induced in mice of two genotypes—WT and Nrf2 tKO mice by cardiotoxin (CTX) injection. To investigate the role of Nrf2 in chronic muscle pathology, mdx mice that share genetic, biochemical, and histopathological features with Duchenne muscular dystrophy (DMD) were crossed with mice lacking transcriptionally active Nrf2 and double knockouts ( mdx /Nrf2 tKO ) were generated. To worsen the dystrophic phenotype, the analysis of disease pathology was also performed in aggravated conditions, by applying a long-term treadmill test. We have observed slightly increased muscle damage in Nrf2 tKO mice after CTX injection. Nevertheless, transcriptional ablation of Nrf2 in mdx mice did not significantly aggravate the most deleterious, pathological hallmarks of DMD related to degeneration, inflammation, fibrotic scar formation, angiogenesis, and the number and proliferation of satellite cells in non-exercised conditions. On the other hand, upon chronic exercises, the degeneration and inflammatory infiltration of the gastrocnemius muscle, but not the diaphragm, turned to be increased in Nrf2 tKO mdx in comparison to mdx mice. In conclusion, the lack of transcriptionally active Nrf2 influences moderately muscle pathology in acute CTX-induced muscle injury and chronic DMD mouse model, without affecting muscle functionality. Hence, in general, we demonstrated that the deficiency of Nrf2 transcriptional activity has no profound impact on muscle pathology in various models of muscle injury.

الإتاحة: https://doi.org/10.1186/s13395-020-00255-0Test

المؤلفون: Loboda, Agnieszka, Dulak, Jozef

المصدر: Antioxidants & Redox Signaling ; ISSN 1523-0864 1557-7716

مصطلحات موضوعية: General Earth and Planetary Sciences, General Environmental Science, Cell Biology, Clinical Biochemistry, Molecular Biology, Physiology, Biochemistry

الإتاحة: https://doi.org/10.1089/ars.2022.0208Test

المؤلفون: Bronisz-Budzyńska, Iwona, Chwalenia, Katarzyna, Mucha, Olga, Podkalicka, Paulina, Karolina-Bukowska-Strakova, Józkowicz, Alicja, Łoboda, Agnieszka, Kozakowska, Magdalena, Dulak, Józef

المساهمون: Narodowe Centrum Nauki

المصدر: Skeletal Muscle ; volume 9, issue 1 ; ISSN 2044-5040

مصطلحات موضوعية: Cell Biology, Molecular Biology, Orthopedics and Sports Medicine

الإتاحة: https://doi.org/10.1186/s13395-019-0207-0Test

المؤلفون: Podkalicka, Paulina, Mucha, Olga, Dulak, Jozef, Loboda, Agnieszka

المساهمون: Narodowe Centrum Nauki

المصدر: Cellular and Molecular Life Sciences ; volume 76, issue 8, page 1507-1528 ; ISSN 1420-682X 1420-9071

مصطلحات موضوعية: Cell Biology, Cellular and Molecular Neuroscience, Pharmacology, Molecular Biology, Molecular Medicine

الإتاحة: https://doi.org/10.1007/s00018-019-03006-7Test

المؤلفون: Loboda, Agnieszka, Damulewicz, Milena, Pyza, Elzbieta, Jozkowicz, Alicja, Dulak, Jozef

المساهمون: Narodowe Centrum Nauki, Narodowe Centrum Badań i Rozwoju

المصدر: Cellular and Molecular Life Sciences ; volume 73, issue 17, page 3221-3247 ; ISSN 1420-682X 1420-9071

مصطلحات موضوعية: Cell Biology, Cellular and Molecular Neuroscience, Pharmacology, Molecular Biology, Molecular Medicine

الإتاحة: https://doi.org/10.1007/s00018-016-2223-0Test

المؤلفون: Loboda, Agnieszka, Jozkowicz, Alicja, Dulak, Jozef

المصدر: Molecules and Cells ; volume 29, issue 5, page 435-442 ; ISSN 1016-8478

مصطلحات موضوعية: Cell Biology, Molecular Biology, General Medicine

الإتاحة: https://doi.org/10.1007/s10059-010-0067-2Test
https://api.elsevier.com/content/article/PII:S1016847823129165?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1016847823129165?httpAccept=text/plainTest

المؤلفون: Jofre-Monseny, Laia, Loboda, Agnieszka, Wagner, Anika E., Huebbe, Patricia, Boesch-Saadatmandi, Christine, Jozkowicz, Alicja, Minihane, Anne-Marie, Dulak, Jozef, Rimbach, Gerald

المساهمون: Bundesministerium für Bildung und Forschung, Ministerstwo Edukacji i Nauki

المصدر: Biochemical and Biophysical Research Communications ; volume 357, issue 1, page 319-324 ; ISSN 0006-291X

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry, Biophysics

الإتاحة: https://doi.org/10.1016/j.bbrc.2007.03.150Test
https://api.elsevier.com/content/article/PII:S0006291X0700647X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0006291X0700647X?httpAccept=text/plainTest

المؤلفون: Loboda, Agnieszka, Stachurska, Anna, Podkalicka, Paulina, Sobczak, Mateusz, Mucha, Olga, Witalisz-Siepracka, Agnieszka, Jozkowicz, Alicja, Dulak, Jozef

المساهمون: Polish Ministry for Science and Higher Education, European Union, Polish Ministry of Science and Higher Education, Leading National Research Center (KNOW), Ministry of Science and Higher Education

المصدر: The International Journal of Biochemistry & Cell Biology ; volume 84, page 46-57 ; ISSN 1357-2725

مصطلحات موضوعية: Cell Biology, Biochemistry

الإتاحة: https://doi.org/10.1016/j.biocel.2017.01.003Test
https://api.elsevier.com/content/article/PII:S1357272517300043?httpAccept=text/plainTest
https://api.elsevier.com/content/article/PII:S1357272517300043?httpAccept=text/xmlTest

المؤلفون: Dulak, Jozef, Zagorska, Anna, Wegiel, Barbara, Loboda, Agnieszka, Jozkowicz, Alicja

المصدر: Cell Biochemistry and Biophysics ; volume 44, issue 1, page 031-042 ; ISSN 1085-9195 1085-9195

مصطلحات موضوعية: Cell Biology, Biochemistry, General Medicine, Biophysics

الإتاحة: https://doi.org/10.1385/cbb:44:1:031Test

المؤلفون: Dulak, Józef, Łoboda, Agnieszka, Zagórska, Anna, Józkowicz, Alicja

المصدر: Antioxidants and Redox Signaling ; volume 6, issue 5, page 858-866 ; ISSN 1523-0864 0000-0000

مصطلحات موضوعية: Cell Biology, Clinical Biochemistry, Molecular Biology, Physiology, Biochemistry

الإتاحة: https://doi.org/10.1089/1523086041797980Test