نتائج البحث - "Kathleen R. Cho"

1

Trp53 null and R270H mutant alleles have comparable effects in regulating invasion, metastasis, and gene expression in mouse colon tumorigenesis

المؤلفون: Ying Feng, Jinyu Tang, Naoya Sakamoto, Megan Green, Maranne Green, Kathleen R. Cho, Eric R. Fearon, Yuki E. Kurosu, Rork Kuick, Jeffry Lin

المصدر: Laboratory investigation; a journal of technical methods and pathology

مصطلحات موضوعية: p53, 0301 basic medicine, Epithelial-Mesenchymal Transition, Carcinogenesis, Adenomatous polyposis coli, mouse model, gain of function, Mutant, Mutation, Missense, Gene Expression, Mice, Transgenic, Adenocarcinoma, Biology, medicine.disease_cause, Article, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Mutant protein, medicine, Animals, Humans, Missense mutation, Neoplasm Invasiveness, tumor suppressor gene, Neoplasm Metastasis, Allele, Molecular Biology, Cell Biology, Null allele, digestive system diseases, 030104 developmental biology, colon cancer, loss of function, 030220 oncology & carcinogenesis, Disease Progression, Cancer research, biology.protein, KRAS, Tumor Suppressor Protein p53, Colorectal Neoplasms

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3062597bd3fe83857f6fc97cd6634503Test
https://doi.org/10.1038/s41374-019-0269-yTest

2

Abstract B11: Collective extrusion initiates dissemination in organotypic model of high-grade serous carcinoma

المؤلفون: Thomas Cattabiani, Estefan Santi, Hongjun Wang, Marcin P. Iwanicki, Sarah Alshehri, Yali Zhai, Sadaf Farsinejad, Douglas Kung, Kathleen R. Cho

المصدر: Clinical Cancer Research. 26:B11-B11

مصطلحات موضوعية: Cancer Research, biology, Serous carcinoma, Cell growth, Chemistry, Cell, Integrin, Serous Tubal Intraepithelial Carcinoma, medicine.disease, Cell biology, Extracellular matrix, Serous fluid, medicine.anatomical_structure, Oncology, medicine, biology.protein, Cytoskeleton

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4d657cd49d9cf48ec32d5ee678db613cTest
https://doi.org/10.1158/1557-3265.ovca19-b11Test

3

IRS1 Regulation by Wnt/β-Catenin Signaling and Varied Contribution of IRS1 to the Neoplastic Phenotype*

المؤلفون: Thomas J. Giordano, Rork Kuick, Hüseyin Kadikoy, Guido T. Bommer, Ayaka Iura, Deanna Sikorski, Eric R. Fearon, Rong Wu, Ying Feng, Kathleen R. Cho

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: endocrine system, Beta-catenin, Biochemistry, Small hairpin RNA, 03 medical and health sciences, Mice, 0302 clinical medicine, Cell Line, Tumor, Neoplasms, Gene expression, Animals, Humans, Neoplastic transformation, Molecular Biology, beta Catenin, 030304 developmental biology, Regulation of gene expression, 0303 health sciences, biology, Mechanisms of Signal Transduction, Cell Biology, Oncogenes, Rats, Gene expression profiling, Gene Expression Regulation, Neoplastic, Wnt Proteins, Cell Transformation, Neoplastic, Phenotype, 030220 oncology & carcinogenesis, Mutation, Cancer research, biology.protein, Insulin Receptor Substrate Proteins, Ectopic expression, Signal transduction, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88a7e1fd0a65e9dda7595e4cd349ff8Test
http://europepmc.org/articles/PMC2804351Test

4

p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes

المؤلفون: Rork Kuick, Thomas J. Giordano, Robert E. Love, Ying Feng, Yali Zhai, Bethany B. Moore, Eric R. Fearon, Kathleen R. Cho, Guido T. Bommer, Isabelle Gerin, Ormond A. MacDougald, Andrew J. Kaczorowski, Zhaohui S. Qin

المصدر: Current Biology. 17(15):1298-1307

مصطلحات موضوعية: Lung Neoplasms, Apoptosis, CELLCYCLE, Biology, General Biochemistry, Genetics and Molecular Biology, Cell Line, Mice, 03 medical and health sciences, 0302 clinical medicine, microRNA, Animals, Humans, Genes, Tumor Suppressor, Gene, Embryonic Stem Cells, 030304 developmental biology, Regulator gene, Regulation of gene expression, 0303 health sciences, Reporter gene, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), Cell Cycle, Transfection, Cell cycle, Molecular biology, 3. Good health, Cell biology, Gene Expression Regulation, Neoplastic, MicroRNAs, Proto-Oncogene Proteins c-bcl-2, MicroRNA 34a, 030220 oncology & carcinogenesis, RNA, Tumor Suppressor Protein p53, General Agricultural and Biological Sciences

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26529afec288c0a3468dd9ed132e7914Test

5

Mouse Model of Human Ovarian Endometrioid Adenocarcinoma Based on Somatic Defects in the Wnt/β-Catenin and PI3K/Pten Signaling Pathways

المؤلفون: Rork Kuick, Samir M. Hanash, Kathleen R. Cho, Eric R. Fearon, Hidetaka Katabuchi, Rong Wu, David E. Misek, Neali Hendrix-Lucas, Donald R. Schwartz, Aytekin Akyol, Bart O. Williams, Yali Zhai

المصدر: Cancer Cell. 11(4):321-333

مصطلحات موضوعية: Cancer Research, CELLCYCLE, Epithelium, Mice, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Ovarian carcinoma, beta Catenin, Oligonucleotide Array Sequence Analysis, Ovarian Neoplasms, 0303 health sciences, biology, Wnt signaling pathway, Cell cycle, Adenocarcinoma, Mucinous, 3. Good health, Gene Expression Regulation, Neoplastic, Survival Rate, Oncology, 030220 oncology & carcinogenesis, Female, Signal transduction, Carcinoma, Endometrioid, Signal Transduction, medicine.medical_specialty, Beta-catenin, Adenomatous Polyposis Coli Protein, Wnt1 Protein, 03 medical and health sciences, Internal medicine, medicine, PTEN, Animals, Humans, PI3K/AKT/mTOR pathway, 030304 developmental biology, Neoplasm Staging, Gene Expression Profiling, Ovary, PTEN Phosphohydrolase, Cell Biology, Cystadenocarcinoma, Serous, Disease Models, Animal, Endocrinology, Catenin, Mutation, biology.protein, Cancer research, Tumor Suppressor Protein p53, Adenocarcinoma, Clear Cell

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b2b10fe0c6bd43b467cd58e5ba9bf6Test

6

Activation of AXIN2 Expression by β-Catenin-T Cell Factor

المؤلفون: Rong Wu, Frank T. Kolligs, Samir M. Hanash, Kathleen R. Cho, Janet Y. M. Leung, Yali Zhai, Eric R. Fearon, Rork Kuick

المصدر: Journal of Biological Chemistry. 277:21657-21665

مصطلحات موضوعية: biology, Adenomatous polyposis coli, Wnt signaling pathway, LRP6, LRP5, Cell Biology, Biochemistry, Cell biology, GSK-3, Catenin, AXIN1, AXIN2, biology.protein, Molecular Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5ba7c6d4d6e13cec02f5fb3bbfb0d4efTest
https://doi.org/10.1074/jbc.m200139200Test

7

γ-Catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of β-catenin

المؤلفون: Kathleen R. Cho, Barbara Kolligs, Gang Hu, Eric R. Fearon, Frank T. Kolligs, Karen M. Hajra, Masachika Tani

المصدر: Genes & Development. 14:1319-1331

مصطلحات موضوعية: Regulation of gene expression, Beta-catenin, Oncogene, biology, Wnt signaling pathway, Plakoglobin, Molecular biology, Cell biology, Catenin, Genetics, biology.protein, Signal transduction, Transcription factor, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::cf8946032b1dd33cb87460f0d3ba891eTest
https://doi.org/10.1101/gad.14.11.1319Test

8

Functional Consequences of Directed Mutations in Human Papillomavirus E6 Proteins: Abrogation of p53-Mediated Cell Cycle Arrest Correlates with p53 Binding and Degradation in Vitro

المؤلفون: Lora Hedrick, Theodore D. Kessis, Sung M. Han, Kathleen R. Cho, Alex W. Chen, Robbert J. C. Slebos

المصدر: Virology. 208:111-120

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60450a920d10cdf3a1affff18833ba3Test
https://doi.org/10.1006/viro.1995.1134Test

9

Murine models of ovarian cancer for preclinical testing of targeted therapeutics: has their time arrived?

المؤلفون: Kathleen R. Cho

المصدر: Cell cycle (Georgetown, Tex.). 11(3)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a960e97fc03611f7914cbf8f41273be6Test
https://pubmed.ncbi.nlm.nih.gov/22262181Test

10

Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer

المؤلفون: Christos Paraskeva, Bert Vogelstein, Eric J. Stanbridge, Daniel Levy, Clare L. Fasching, Kenneth W. Kinzler, Kathleen R. Cho, Michele C. Goyette

المصدر: Molecular and Cellular Biology. 12:1387-1395

مصطلحات موضوعية: Tumor suppressor gene, Chromosome Transfer, Molecular Sequence Data, Biology, Transfection, medicine.disease_cause, Polymerase Chain Reaction, Chromosome 15, Transforming Growth Factor beta, Chromosome 18, Tumor Cells, Cultured, medicine, Humans, Genes, Tumor Suppressor, Molecular Biology, Alleles, Chromosomes, Human, Pair 15, Base Sequence, Mutagenicity Tests, Genetic transfer, DNA, Neoplasm, Cell Biology, Molecular biology, Chromosome 17 (human), Kinetics, Tumor progression, Mutation, Cancer research, Chromosomes, Human, Pair 5, Chromosomes, Human, Pair 18, Colorectal Neoplasms, Carcinogenesis, Polymorphism, Restriction Fragment Length, Chromosomes, Human, Pair 17, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076c402ace870ee59a50824e58f3cf61Test
https://doi.org/10.1128/mcb.12.3.1387Test

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