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المؤلفون: Josée Dupuis, Victoria E. Jackson, Hanfei Xu, Brian D. Hobbs, Edwin K. Silverman, Michael H. Cho, Megan L. Grove, Jennifer N. Nguyen, Jiangyuan Liu, George T. O'Connor, Natalie Terzikhan, Ani Manichaikul, Patricia A. Cassano, Colleen M. Sitlani, Buhm Han, Ian P. Hall, Bing Yu, Sina A. Gharib, Lies Lahousse, Louise V. Wain, Traci M. Bartz, Christopher J. Benway, R. Graham Barr, Phuwanat Sakornsakolpat, Guy Brusselle, Stephanie J. London, Kun Hee Kim, Martin D. Tobin, Matthew Moll, Jinkyeong Park, Woo Jin Kim, Bonnie K Patchen, Stephen S. Rich
المساهمون: Epidemiology
المصدر: Am J Physiol Lung Cell Mol Physiol
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
American Journal of Physiology-Lung Cellular and Molecular Physiology, 321(1), L130-L143. American Physiological Societyمصطلحات موضوعية: 0301 basic medicine, Nonsynonymous substitution, Pulmonary and Respiratory Medicine, EXPRESSION, Genetic Markers, Physiology, Genome-wide association study, Biology, Polymorphism, Single Nucleotide, chronic obstructive pulmonary disease, GENETIC ASSOCIATION, 03 medical and health sciences, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, DESIGN, Meta-Analysis as Topic, Physiology (medical), Medicine and Health Sciences, genomics, COPD, Humans, Exome, Genetic Predisposition to Disease, exon, Allele, GENOME-WIDE ASSOCIATION, Genotyping, Genetic association, Genetics, ZINC-FINGER PROTEIN, Odds ratio, Cell Biology, GENOTYPE, Minor allele frequency, LUNG-FUNCTION, functional, 030104 developmental biology, 030228 respiratory system, ATHEROSCLEROSIS, Gene Expression Regulation, SMOKING, exome, Genome-Wide Association Study, Research Article
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cb68b992b8fdd29d75b61efee547b4Test
https://doi.org/10.1152/AJPLUNG.00009.2021Test -
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المؤلفون: Dhruma Thakker, Robert J. Hall, Ian P. Hall, Charlotte K. Billington, Jonathan O’Loughlin, Ian Sayers
المصدر: FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(7)
مصطلحات موضوعية: 0301 basic medicine, Respiratory System, Mutation, Missense, Single-nucleotide polymorphism, Genome-wide association study, Bronchi, Biology, Biochemistry, Receptors, G-Protein-Coupled, 03 medical and health sciences, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Genetics, Humans, Receptor, Molecular Biology, Gene, Cells, Cultured, Cell Proliferation, Cell growth, Epithelial Cells, Muscle, Smooth, Genomics, Cell biology, CTGF, 030104 developmental biology, Expression quantitative trait loci, Functional genomics, 030217 neurology & neurosurgery, Biotechnology, Signal Transduction
وصف الملف:
PDF الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45944cf0f0b3d6ea4df013b8baf5c01bTest
https://pubmed.ncbi.nlm.nih.gov/34165809Test -
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المؤلفون: Charlotte K. Billington, Gerard H. Koppelman, Liam G Heaney, Adel H. Mansur, Jenny Hankinson, Martijn C. Nawijn, Corry-Anke Brandsma, Sangita Bhaker, Andrew M. Fogarty, Dominick E. Shaw, Michael A. Portelli, Cornelis J. Vermeulen, Judith M. Vonk, Nick Shrine, Amanda P. Henry, Ian Sayers, Yohan Bossé, Maria Ketelaar, Martin D. Tobin, Peter H. Howarth, David C. Nickle, Néomi S. Grotenboer, Ma'en Obeidat, Gabrielle A. Lockett, John W. Holloway, Christopher E. Brightling, Alen Faiz, Rekha Chaudhuri, Tricia M. McKeever, Simon R. Johnson, Paul de Vos, Dirkje S. Postma, Zara Pogson, Neil C. Thomson, Sharon Brouwer, Maarten van den Berge, Angela Simpson, Amisha Singapuri, Robert Niven, F. Nicole Dijk, Ian P. Hall, Louise V. Wain, John D Blakey
المساهمون: Groningen Research Institute for Asthma and COPD (GRIAC), Translational Immunology Groningen (TRIGR), Man, Biomaterials and Microbes (MBM)
المصدر: Portelli, M A, Dijk, F N, Ketelaar, M E, Shrine, N, Hankinson, J, Bhaker, S, Grotenboer, N S, Obeidat, M, Henry, A P, Billington, C K, Shaw, D, Johnson, S R, Pogson, Z E, Fogarty, A, McKeever, T M, Nickle, D C, Bossé, Y, van den Berge, M, Faiz, A, Brouwer, S, Vonk, J M, de Vos, P, Brandsma, C-A, Vermeulen, C J, Singapuri, A, Heaney, L G, Mansur, A H, Chaudhuri, R, Thomson, N C, Holloway, J W, Lockett, G A, Howarth, P H, Niven, R, Simpson, A, Blakey, J D, Tobin, M D, Postma, D S, Hall, I P, Wain, L V, Nawijn, M C, Brightling, C E, Koppelman, G H & Sayers, I 2020, ' Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium ', JCI insight, vol. 5, no. 8, pp. 1-19 . https://doi.org/10.1172/jci.insight.132446Test
JCI Insight
JCI Insight, 5(8):132446. AMER SOC CLINICAL INVESTIGATION INCمصطلحات موضوعية: HAY-FEVER, EXPRESSION, 0301 basic medicine, medicine.medical_specialty, Genotype, IL1RL1, Single-nucleotide polymorphism, Genome-wide association study, Locus (genetics), Respiratory Mucosa, VARIANTS, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Molecular genetics, Genetics, medicine, Humans, Genetic Predisposition to Disease, Genetic variation, GENOME-WIDE ASSOCIATION, Lung, Asthma, LARGE-SCALE, Haplotype, Cell Biology, General Medicine, ST2, medicine.disease, Interleukin-1 Receptor-Like 1 Protein, Phenotype, respiratory tract diseases, GENETIC RISK-FACTORS, DIFFERENTIATION, 030104 developmental biology, 030220 oncology & carcinogenesis, Immunology, IL-33, INTERLEUKIN-1 RECEPTOR, Research Article
وصف الملف: application/pdf; text
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35eec0d3bd47361ef723e102569f7099Test
https://doi.org/10.1172/jci.insight.132446Test -
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المؤلفون: Ian P. Hall, Ian Sayers, Michael A. Portelli, Robert J. Hall
المصدر: Molecular pathology and funct. genomics.
مصطلحات موضوعية: Transcriptome, Messenger RNA, Downregulation and upregulation, business.industry, Transcription (biology), Gene expression, Medicine, business, Actin cytoskeleton, Hox gene, Gene, Cell biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::cddd885feb6a67fcff77908dd7f960f2Test
https://doi.org/10.1183/13993003.congress-2019.pa5410Test -
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المؤلفون: Charlotte K. Billington, Amanda P. Henry, B. Kc, Bo Liu, Ian Sayers, G. Qian, Ian P. Hall
المصدر: C63. MECHANISTIC STUDIES IN COPD.
مصطلحات موضوعية: Chemistry, Function (biology), Cell biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::724a75dd581d414abdc96c41e04006c3Test
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5382Test -
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المؤلفون: Nick Shrine, UK BiLEVE, Ian P. Hall, Louise V. Wain, Ian Sayers, Martin D. Tobin, María Soler Artigas, Tricia M. McKeever
المصدر: PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0170222 (2017)مصطلحات موضوعية: 0301 basic medicine, Gerontology, Pulmonology, Genome-wide association study, Bioinformatics, Pulmonary function testing, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Missing heritability problem, Medicine and Health Sciences, COPD, Multidisciplinary, Chromosome Biology, Applied Mathematics, Simulation and Modeling, Genomics, Gene Pool, 3. Good health, Respiratory Function Tests, Physical Sciences, Medicine, Engineering and Technology, Algorithms, Research Article, Adult, Quality Control, Science, Chronic Obstructive Pulmonary Disease, Single-nucleotide polymorphism, Research and Analysis Methods, Polymorphism, Single Nucleotide, Chromosomes, 03 medical and health sciences, Industrial Engineering, medicine, Genetics, Genome-Wide Association Studies, Humans, Allele frequency, Alleles, Genetic association, Evolutionary Biology, Population Biology, business.industry, Biology and Life Sciences, Computational Biology, Human Genetics, Cell Biology, medicine.disease, Genome Analysis, Minor allele frequency, 030104 developmental biology, 030228 respiratory system, Genetic Loci, Case-Control Studies, business, Population Genetics, Mathematics
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc1bb9beeb74f94ef7398cf851c9abfTest
https://pubmed.ncbi.nlm.nih.gov/28114305Test -
7The Ser82 RAGE variant affects lung function and serum RAGE in smokers and sRAGE production in vitro
المؤلفون: Charlotte K. Billington, Tracy L. Rimington, Ceri E. Stewart, Ian P. Hall, Iain Kilty, Catherine Gowland, Simon Kebede Merid, Andrew J. Wardlaw, Caroline Swan, Erik Melén, Ian Sayers, Sangita Bhaker, Charlotte E. Bolton, Anders Mälarstig, Stuart G Parker, Abdul Kader Kheirallah, Amanda P. Henry, Carl P. Nelson, Suzanne Miller, Ma'en Obeidat, Emily Hodge, Miriam F. Moffatt
المصدر: PLoS ONE
PLoS ONE, Vol 11, Iss 10, p e0164041 (2016)مصطلحات موضوعية: 0301 basic medicine, Male, Lung Development, Advanced Glycosylation End Product-Specific Receptor, Pulmonology, Molecular biology, Organogenesis, SPLICE VARIANTS, Receptor for Advanced Glycation End Products, lcsh:Medicine, Gene Expression, Genome-wide association study, EMPHYSEMA, DEVELOPMENTAL EXPRESSION, Biochemistry, Epithelium, Pulmonary function testing, RAGE (receptor), chemistry.chemical_compound, Pulmonary Disease, Chronic Obstructive, Sequencing techniques, Animal Cells, Medicine and Health Sciences, Medicine, lcsh:Science, Lung, COPD, Multidisciplinary, biology, Messenger RNA, Smoking, EPITHELIAL-CELLS, RNA sequencing, Middle Aged, respiratory system, Multidisciplinary Sciences, Nucleic acids, medicine.anatomical_structure, Advanced glycation end-product, Science & Technology - Other Topics, Cellular Types, Anatomy, GLYCATION END-PRODUCTS, Research Article, Plasmids, SOLUBLE RECEPTOR, Genotype, General Science & Technology, Chronic Obstructive Pulmonary Disease, RNA Splicing, Bronchi, HMGB1, ENDPRODUCTS, OBSTRUCTIVE PULMONARY-DISEASE, Polymorphism, Single Nucleotide, Cell Line, 03 medical and health sciences, FEV1/FVC ratio, Young Adult, Extraction techniques, Fetus, MD Multidisciplinary, Genetics, Humans, RNA, Messenger, Alleles, Science & Technology, business.industry, lcsh:R, Biology and Life Sciences, Epithelial Cells, Cell Biology, medicine.disease, GENE, RNA extraction, respiratory tract diseases, Research and analysis methods, 030104 developmental biology, Biological Tissue, Molecular biology techniques, chemistry, Case-Control Studies, Immunology, biology.protein, RNA, lcsh:Q, OVEREXPRESSION, business, Organism Development, Developmental Biology, Genome-Wide Association Study
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802d73c51ae1801579a966f85556e295Test
https://irep.ntu.ac.uk/id/eprint/29060/1/PubSub6566_Nelson.PDFTest -
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المؤلفون: Ian P. Hall, Simon R. Johnson, L Magowan, M. E. Roberts
المصدر: European Respiratory Journal. 37:1482-1493
مصطلحات موضوعية: Adult, Male, Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, Bronchi, Matrix metalloproteinase, Biology, Collagen Type I, Receptor tyrosine kinase, Cell Line, Extracellular matrix, Young Adult, Discoidin Domain Receptor 1, Cell Adhesion, medicine, Humans, Cell adhesion, Cells, Cultured, Aged, Cell Proliferation, Wound Healing, DDR1, Gene knockdown, Smoking, Receptor Protein-Tyrosine Kinases, Middle Aged, Asthma, Cell biology, Matrix Metalloproteinase 9, Gene Knockdown Techniques, Matrix Metalloproteinase 7, biology.protein, Matrix Metalloproteinase 2, Female, Wound healing, Discoidin domain
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58f10edbba6aa8f6bc92791e133d800Test
https://doi.org/10.1183/09031936.00039710Test -
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المؤلفون: Ian P. Hall, Ian Sayers, Charlotte K. Billington, Shailendra Singh
المصدر: American Journal of Physiology-Lung Cellular and Molecular Physiology. 299:L169-L183
مصطلحات موضوعية: Male, Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, 3-Hydroxysteroid Dehydrogenases, Physiology, Mesenchyme, Cathepsin K, Myocytes, Smooth Muscle, Cell, Bronchi, Biology, Culture Media, Serum-Free, Flow cytometry, Physiology (medical), medicine, Humans, Myocyte, Cell Lineage, Fibroblast, Cells, Cultured, Actin, medicine.diagnostic_test, Aldo-Keto Reductase Family 1 Member C3, Mesenchymal Stem Cells, Cell Biology, Fibroblasts, respiratory system, Flow Cytometry, Immunohistochemistry, Actins, Cell biology, medicine.anatomical_structure, Hydroxyprostaglandin Dehydrogenases, Calmodulin-Binding Proteins, Thromboxane-A Synthase, Airway, Integrin alpha Chains, Myofibroblast, Biomarkers
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd70cb7deda31b376c27a56efa7710fTest
https://doi.org/10.1152/ajplung.00311.2009Test -
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المؤلفون: Ian P. Hall, Sangita Bhaker, Charlotte K. Billington, Caroline Swan, Bo Liu, Abdul Kader Kheirallah, Amanda P. Henry
المصدر: Physiological Reports
مصطلحات موضوعية: 0301 basic medicine, Cell type, Physiology, Bronchi, Respiratory Mucosa, Chloride, 03 medical and health sciences, 0302 clinical medicine, Control of Breathing, Chloride Channels, Physiology (medical), Membrane Physiology, human bronchial epithelial cells, Cyclic AMP, medicine, Humans, Original Research, Respiratory Conditions Disorder and Diseases, CLIC1, Chemistry, Cell biology, 030104 developmental biology, 030220 oncology & carcinogenesis, Chloride channel, Whole cell, Intracellular, Homeostasis, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9eccafe3ceeff1e5148444ec707be2Test
https://doi.org/10.14814/phy2.13508Test