دورية أكاديمية
Chemical inhibitors of TNF signal transduction in human neutrophils point to distinct steps in cell activation
| العنوان: | Chemical inhibitors of TNF signal transduction in human neutrophils point to distinct steps in cell activation |
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| المؤلفون: | Han, Hyunsil, Roberts, Julia, Lou, Olivia, Muller, Willam A, Nathan, Noah, Nathan, Carl |
| المساهمون: | National Institutes of Health, Cancer Research Institute, Department of Microbiology and Immunology |
| المصدر: | Journal of Leukocyte Biology ; volume 79, issue 1, page 147-154 ; ISSN 1938-3673 0741-5400 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Cell Biology, Immunology, Immunology and Allergy |
| الوصف: | Chemical screening identified three small compounds that selectively inhibited activation of the respiratory burst (RB) of human neutrophils in response to tumor necrosis factor (TNF) and formylated peptide but not phorbol ester and spared the ability of neutrophils to kill bacteria. These compounds partially inhibited TNF-triggered cytoskeletal rearrangements without blocking adhesion or transmigation of polymorphonuclear neutrophils through TNF-activated monolayers of endothelial cells. The compounds were nontoxic to neutrophils and endothelial cells. They had no direct inhibitory effect on the tyrosine kinases Src, Syk, or Pyk2. However, their differential effects on cell spreading, bacteria-induced RB, TNF-induced degranulation, TNF-induced protein tyrosine phosphorylation, and TNF-induced Syk activation suggested that each may act on different elements of neutrophil signaling pathways. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1189/jlb.0605308 |
| الإتاحة: | https://doi.org/10.1189/jlb.0605308Test https://academic.oup.com/jleukbio/article-pdf/79/1/147/49643836/jlb0147.pdfTest |
| حقوق: | https://academic.oup.com/pages/standard-publication-reuse-rightsTest |
| رقم الانضمام: | edsbas.CFA2A563 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1189/jlb.0605308 |
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