HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice
| العنوان: | HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice |
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| المؤلفون: | Feng Chun Yang, Fei Wang, Bing Xu, Bernd B. Zeisig, Suming Huang, Ganqian Zhu, Chi Wai Eric So, Ya Cui, Bowen Yan, Yi Qiu, Qian Lai, Huacheng Luo, Tsz Kan Fung, Ying Guo, Christopher R. Cogle, Jie Zha, Wei Li, Mingjiang Xu, Jianfeng Xu |
| المصدر: | Luo, H, Zhu, G, Xu, J, Lai, Q, Yan, B, Guo, Y, Fung, T K, Zeisig, B B, Cui, Y, Zha, J, Cogle, C, Wang, F, Xu, B, Yang, F C, Li, W, So, C W E, Qiu, Y, Xu, M & Huang, S 2019, ' HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice ', CANCER CELL, vol. 36, no. 6, pp. 645-659.E8 . https://doi.org/10.1016/j.ccell.2019.10.011Test Cancer cell |
| بيانات النشر: | Elsevier BV, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, HOX and hematopoietic gene regulation, Biology, WNT signaling targets, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Transcription (biology), enhancer/promoter accessibility, medicine, Animals, Cell Self Renewal, Hox gene, Cell Proliferation, Homeodomain Proteins, Gene Expression Regulation, Leukemic, leukemia, HOTTIP transgenic mice, Myeloid leukemia, Hematopoietic stem cell, Cell Biology, Hematopoietic Stem Cells, Chromatin, HSC self-renewal, Cell biology, Leukemia, Myeloid, Acute, Haematopoiesis, 030104 developmental biology, medicine.anatomical_structure, HOTTIP lncRNA, Oncology, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, CTCF boundary, RNA, Long Noncoding, chromatin domain, Homeotic gene, Reprogramming |
| الوصف: | SUMMARY Long non-coding RNAs (lncRNAs) are critical for regulating HOX genes, aberration of which is a dominant mechanism for leukemic transformation. How HOX gene-associated lncRNAs regulate hematopoietic stem cell (HSC) function and contribute to leukemogenesis remains elusive. We found that HOTTIP is aberrantly activated in acute myeloid leukemia (AML) to alter HOXA-driven topologically associated domain (TAD) and gene expression. HOTTIP loss attenuates leukemogenesis of transplanted mice, while reactivation of HOTTIP restores leukemic TADs, transcription, and leukemogenesis in the CTCF-boundary-attenuated AML cells. Hottip aberration in mice abnormally promotes HSC self-renewal leading to AML-like disease by altering the homeotic/hematopoietic gene-associated chromatin signature and transcription program. Hottip aberration acts as an oncogenic event to perturb HSC function by reprogramming leukemic-associated chromatin and gene transcription. In Brief Luo et al. find that the lncRNA HOTTIP is overexpressed in acute myeloid leukemia (AML). They show that HOTTIP coordinates topologically associated domain organization in the AML genome, including the posterior HOXA genes and various key hematopoietic regulator loci, and is important for AML growth. Graphical Abstract |
| وصف الملف: | application/pdf |
| تدمد: | 1535-6108 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9f7f066edb92a8633d26640a10c078Test https://doi.org/10.1016/j.ccell.2019.10.011Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ac9f7f066edb92a8633d26640a10c078 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15356108 |
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