التفاصيل البيبلوغرافية
العنوان:
Exposure to UV radiation and risk of Hodgkin lymphoma: A pooled analysis
المؤلفون:
Paul Brennan , Pierluigi Cocco , Mads Melbye , Ellen T. Chang , Paolo Boffetta , Sally L. Glaser , Henrik Hjalgrim , Anthony Staines , Lenka Foretova , Nikolaus Becker , Alain Monnereau , Jacqueline Clavel , Silvia de Sanjosé , Ingrid Glimelius , Alexandra Nieters , Clayton W. Schupp , Karin E. Smedby , Eleanor Kane , Marc Maynadié
المساهمون:
Monnereau, A., Glaser, S.L., Schupp, C.W., Smedby, K.E., De Sanjosé, S., Kane, E., Melbye, M., Forétova, L., Maynadié, M., Staines, A., Becker, N., Nieters, A., Brennan, P., Boffetta, P., Cocco, P., Glimelius, I., Clavel, J., Hjalgrim, H., Chang, E.T.
سنة النشر:
2013
مصطلحات موضوعية:
Oncology , Male , Epstein-Barr Virus Infections , DNA Repair , Sunburn , Skin Pigmentation , Comorbidity , Biochemistry , T-Lymphocytes, Regulatory , visual_art.visual_artist , immune system diseases , hemic and lymphatic diseases , Young adult , Aged, 80 and over , Lymphoid Neoplasia , Sunbathing , integumentary system , Exposure Category , Inside BLOOD , Confounding , Age Factors , Confounding Factors, Epidemiologic , Hematology , Middle Aged , Hodgkin Disease , Europe , Hodgkin lymphoma (HL) , visual_art , Sunlight , Female , Adult , medicine.medical_specialty , Adolescent , Ultraviolet Rays , Immunology , Biology , White People , Young Adult , Internal medicine , medicine , Humans , Ultraviolet radiation (UVR) , tumor-cell Epstein-Barr virus (EBV) , Aged , fungi , Case-control study , Models, Immunological , Dose-Response Relationship, Radiation , Cell Biology , Odds ratio , medicine.disease , Relative risk , Case-Control Studies , DNA Damage
الوصف:
Ultraviolet radiation (UVR) exposure has been inversely associated with Hodgkin lymphoma (HL) risk, but only inconsistently, only in a few studies, and without attention to HL heterogeneity. We conducted a pooled analysis of HL risk focusing on type and timing of UVR exposure and on disease subtypes by age, histology, and tumor-cell Epstein-Barr virus (EBV) status. Four case-control studies contributed 1320HLcasesand 6381 controls. We estimated lifetime, adulthood, and childhood UVR exposure and history of sunburn and sunlamp use. We used 2-stage estimation with mixed-effects models and weighted pooled effect estimates by inverse marginal variances. We observed statistically significant inverse associations with HL risk for UVR exposures during childhood and adulthood, sunburn history, and sunlamp use, but we found no significant doseresponse relationships. Risks were significant only for EBV-positive HL (pooled odds ratio, 0.56; 95% confidence interval, 0.35 to 0.91 for the highest overall UVR exposure category), with a significant linear trend for overall exposure (P 5.03). Pooled relative risk estimates were not heterogeneous across studies. Increased UVR exposure may protect against HL, particularly EBV-positive HL. Plausible mechanisms involving UVR induction of regulatory T cells or the cellular DNA damage response suggest opportunities for new prevention targets. © 2013 by The American Society of Hematology.
وصف الملف:
ELETTRONICO
اللغة:
English
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18635c548616e87939c2260b0b2dd23Test http://hdl.handle.net/11585/675631Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....d18635c548616e87939c2260b0b2dd23
قاعدة البيانات:
OpenAIRE
