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المؤلفون: Cristina Beltrami, Owen J. L. Rackham, Costanza Emanueli, Nithya Devapragash, Wei-Ping Yu, Xi-Ming Sun, Stuart A. Cook, Norbert Hubner, Francesco Pesce, Ee Ling Heng, Elisabeth Tan, Aida Moreno-Moral, Enrique Lara-Pezzi, Gianni D Angelini, Enrico Petretto, Huimei Chen, Paul J.R. Barton, Nathan Harmston, Michal Pravenec, Sebastian Schafer, Maxime Rotival, Nicole Tee, Massimilano Mancini, Leanne E. Felkin, Leonardo Bottolo, Prashant K. Srivastava, Kirill Shkura
المساهمون: Cardiovascular and Metabolic Disorders [Singapor] (cvmd), Duke-NUS Medical School [Singapore], Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Ospedale San Giovanni di Dio, Firenze, National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Faculty of Medicine [London, UK], Imperial College London, Agency for science, technology and research [Singapore] (A*STAR), Institute of Molecular and Cell Biology, National University of Singapore (NUS)-Agency for science, technology and research [Singapore] (A*STAR), MRC London Institute of Medical Sciences (LMC), National Heart Centre Singapore (NHCS), Royal Brompton and Harefield NHS Foundation Trust, Cardiovascular Research Centre [London], Centro Nacional de Investigaciones Cardiovasculares Carlos III [Madrid, Spain] (CNIC), Instituto de Salud Carlos III [Madrid] (ISC), University of Bristol [Bristol], Institute of Physiology [Prague], Czech Academy of Sciences [Prague] (CAS), University of Cambridge [UK] (CAM), The Alan Turing Institute, MRC Biostatistics Unit [Cambridge, UK], Max Delbrück Center for Molecular Medicine [Berlin] (MDC), Helmholtz-Gemeinschaft = Helmholtz Association, German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], The research was primarily supported by National Medical Research Council (NMRC) Singapore grant NMRC/CBRG/0106/2016 (to E.P.) and the British Heart Foundation (BHF) Ph.D. Studentship grant FS/11/25/28740 (to E.P). We acknowledge additional funding support from European Union FP7 CardioNeT-ITN-289600 (to E.L.-P., S.A.C., and P.J.R.B.), Heart Research UK (to P.J.R.B.), NIHR CV BRU of Royal Brompton and Harefield, NHS Foundation Trust (to S.A.C. and P.J.R.B.), BHF (to S.A.C.), Leducq Foundation (to S.A.C.), MRC UK (to S.A.C.), BHF Program Grant no. RG/15/5/31446 (to C.E. and E.P.). M.P. was supported by Praemium Academiae award of the Czech Academy of Sciences and grant 14-36804G from the Czech Science Foundation., We wish to thank Dr. Jacques Behmoaras for contributing critical and constructive comments to the manuscript., European Project: 289600,EC:FP7:PEOPLE,FP7-PEOPLE-2011-ITN,CARDIONET(2012), Moreno-Moral, Aida [0000-0002-8155-3146], Barton, Paul J. R. [0000-0002-1165-7767], Schafer, Sebastian [0000-0002-6909-8275], Bottolo, Leonardo [0000-0002-6381-2327], Cook, Stuart A. [0000-0001-6628-194X], Petretto, Enrico [0000-0003-2163-5921], Apollo - University of Cambridge Repository, National Medical Research Council (Singapur), British Heart Foundation, Unión Europea. Comisión Europea, National Institutes of Health (Estados Unidos), Czech Science Foundation, Fondation Leducq, NHS Foundation Trusth, University of Bari Aldo Moro (UNIBA), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Leducq Foundation for Cardiovascular Research, Commission of the European Communities, Heart Research UK, Medical Research Council (MRC), Barton, Paul JR [0000-0002-1165-7767], Cook, Stuart A [0000-0001-6628-194X]
المصدر: Nature Communications
Nature Communications, 2019, 10 (1), pp.3616. ⟨10.1038/s41467-019-11551-9⟩
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Chen, H, Moreno-Moral, A, Pesce, F, Devapragash, N, Mancini, M, Heng, E L, Rotival, M, Srivastava, P K, Harmston, N, Shkura, K, Rackham, O J L, Yu, W P, Sun, X M, Tee, N G Z, Tan, E L S, Barton, P J R, Felkin, L E, Lara-Pezzi, E, Angelini, G, Beltrami, C, Pravenec, M, Schafer, S, Bottolo, L, Hubner, N, Emanueli, C, Cook, S A & Petretto, E 2019, ' WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signalling ', Nature Communications, vol. 10, 3616 . https://doi.org/10.1038/s41467-019-11551-9Test
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.3616. ⟨10.1038/s41467-019-11551-9⟩
Repisalud
Instituto de Salud Carlos III (ISCIII)مصطلحات موضوعية: Male, 45/43, BLOOD-PRESSURE, 02 engineering and technology, MESH: Protein Isoforms, MESH: Heart Diseases / genetics, Mice, Transforming Growth Factor beta, 42/44, Fibrosis, Protein Isoforms, Medicine, MESH: Animals, lcsh:Science, MESH: Ubiquitin-Protein Ligases / genetics, MESH: Fibrosis / metabolism, MESH: Genetic Predisposition to Disease* / genetics, GENE-EXPRESSION, Regulation of gene expression, Extracellular Matrix Proteins, MESH: Middle Aged, MESH: Fibrosis / genetics, TGF-BETA, MESH: Heart Diseases / metabolism, MESH: Ubiquitin-Protein Ligases / metabolism, 3. Good health, Cell biology, Ubiquitin ligase, FIBROBLAST, MESH: Young Adult, Science & Technology - Other Topics, 64/60, Cardiomyopathies, 0210 nano-technology, Cardiac function curve, Science, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, REVEALS, Humans, Aged, MESH: Adolescent, Science & Technology, MESH: Humans, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], IDENTIFICATION, MESH: Smad2 Protein / metabolism, MESH: Extracellular Matrix Proteins / metabolism, MESH: Adult, MESH: Cardiomyopathies / metabolism, medicine.disease, 030104 developmental biology, Cardiovascular and Metabolic Diseases, E3 UBIQUITIN LIGASE, RAT, DETERMINANT, lcsh:Q, Myocardial fibrosis, MESH: Female, 0301 basic medicine, Cardiac fibrosis, General Physics and Astronomy, Smad2 Protein, Gene Regulatory Networks, 13/89, MESH: Aged, MESH: Transforming Growth Factor beta / metabolism, Multidisciplinary, biology, MESH: Smad2 Protein / genetics, article, Middle Aged, MESH: Cardiomyopathies / genetics, 021001 nanoscience & nanotechnology, 692/4019/592/75/74, MESH: Gene Expression Regulation, Multidisciplinary Sciences, Centre for Surgical Research, HEART-FAILURE, Female, 38/39, Adult, Adolescent, Heart Diseases, MESH: Mice, Transgenic, Ubiquitin-Protein Ligases, Mice, Transgenic, 14/32, 82/80, Young Adult, Animals, Genetic Predisposition to Disease, 14/35, MESH: Mice, Pressure overload, business.industry, General Chemistry, MESH: Male, Gene Expression Regulation, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Ubiquitin ligases, Heart failure, 13/51, biology.protein, 631/45/474/2073, MESH: Gene Regulatory Networks, business
وصف الملف: application/pdf; text; application/zip; text/xml
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9a8eae768aaa77cac0482318b75243Test
https://doi.org/10.1038/s41467-019-11551-9Test -
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المؤلفون: Bram C. J. van der Eerden, Johannes P.T.M. van Leeuwen, Karel Bezstarosti, Jeroen Demmers, Marco Eijken, Rodrigo D. A. M. Alves, Jan A N Verhaar
المساهمون: Biochemistry, Internal Medicine, Orthopedics and Sports Medicine
المصدر: Journal of Proteome Research, 10(10), 4725-4733. American Chemical Society
Alves, R D A M, Demmers, J A A, Bezstarosti, K, van der Eerden, B C J, Verhaar, J A N, Eijken, M & van Leeuwen, J P T M 2011, ' Unraveling the human bone microenvironment beyond the classical extracellular matrix proteins : a human bone protein library ', Journal of Proteome Research, vol. 10, no. 10, pp. 4725-33 . https://doi.org/10.1021/pr200522nTestمصطلحات موضوعية: Male, Calcium/metabolism, Proteome, Human bone, Bone matrix, Bone and Bones/metabolism, Bone tissue, Tandem Mass Spectrometry/methods, Biochemistry, Bone and Bones, Mass Spectrometry, Extracellular Matrix Proteins/metabolism, Osteoarthritis/metabolism, Bone remodeling, Extracellular matrix, SDG 3 - Good Health and Well-being, Tandem Mass Spectrometry, Form and function, Osteoarthritis, medicine, Humans, Mass Spectrometry/methods, Aged, Aged, 80 and over, Extracellular Matrix Proteins, Chemistry, Chromatography, Liquid/methods, Computational Biology, General Chemistry, Computational Biology/methods, Middle Aged, Cell biology, medicine.anatomical_structure, Immunology, Calcium, Electrophoresis, Polyacrylamide Gel, Female, Chromatography, Liquid
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b60b5043b937b8bebdf866e3d1aacbTest
https://doi.org/10.1021/pr200522nTest -
3
المؤلفون: Hiroshi Maita, Ken-ichi Matsumoto, Hiroyoshi Ariga, Shinpei Fujie
المصدر: Biological and Pharmaceutical Bulletin. 32:1795-1799
مصطلحات موضوعية: Focal Adhesion Protein-Tyrosine Kinases/metabolism, Signal Transduction, p38 mitogen-activated protein kinases, Pharmaceutical Science, Cell Adhesion/physiology, p38 Mitogen-Activated Protein Kinases, Phosphorylation, Tenascin X, Focal adhesion, Mice, p38 Mitogen-Activated Protein Kinases/metabolism, Cell Adhesion, Animals, Cell adhesion, Cells, Cultured, Pharmacology, Extracellular Matrix Proteins, Extracellular Matrix Proteins/metabolism, biology, tenascin-X, p38 mitogen-activated protein kinase, cell detachment, Kinase, Tenascin, Fibroblasts/metabolism, General Medicine, Fibroblasts, Molecular biology, Cell biology, Focal Adhesion Protein-Tyrosine Kinases, Tenascin/metabolism, Mitogen-activated protein kinase, biology.protein, Signal transduction
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c10c26abb0c03bcb725b9d939741a3Test
https://doi.org/10.1248/bpb.32.1795Test -
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المؤلفون: Fisun Hamaratoglu, Sven Bergmann, George Pyrowolakis, Aitana Morton de Lachapelle, Markus Affolter
المساهمون: University of Zurich, Hamaratoglu, Fisun
المصدر: PLoS biology
PLoS Biology, Vol 9, Iss 10, p e1001182 (2011)
PLoS Biology, vol. 9, no. 10, pp. e1001182
PLoS Biologyمصطلحات موضوعية: Male, 0302 clinical medicine, SX00 SystemsX.ch, 2400 General Immunology and Microbiology, Morphogenesis, Drosophila Proteins, Wings, Animal, Pattern Formation, Phosphorylation, Biology (General), Genetics, 0303 health sciences, Extracellular Matrix Proteins, biology, General Neuroscience, Drosophila Melanogaster, Systems Biology, Statistics, Gene targeting, 2800 General Neuroscience, Animal Models, Organ Size, Cell biology, DNA-Binding Proteins, Imaginal disc, Larva, Female, Drosophila melanogaster, General Agricultural and Biological Sciences, Drosophila Protein, Morphogen, Research Article, animal structures, QH301-705.5, SX20 Research, Technology and Development Projects, Recombinant Fusion Proteins, Green Fluorescent Proteins, Nerve Tissue Proteins, 1100 General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Model Organisms, SX15 WingX, 1300 General Biochemistry, Genetics and Molecular Biology, Animals, Biology, 030304 developmental biology, Homeodomain Proteins, Wing, General Immunology and Microbiology, Decapentaplegic, DNA-Binding Proteins/metabolism, Drosophila Proteins/metabolism, Drosophila melanogaster/growth & development, Drosophila melanogaster/metabolism, Extracellular Matrix Proteins/metabolism, Green Fluorescent Proteins/metabolism, Homeodomain Proteins/metabolism, Larva/growth & development, Larva/metabolism, Microscopy, Fluorescence, Nerve Tissue Proteins/metabolism, Recombinant Fusion Proteins/metabolism, Repressor Proteins/metabolism, T-Box Domain Proteins/metabolism, Transcription Factors/metabolism, Wing/blood supply, Wing/growth & development, Molecular Development, biology.organism_classification, Signaling, Morphogens, Repressor Proteins, 570 Life sciences, T-Box Domain Proteins, 030217 neurology & neurosurgery, Mathematics, Developmental Biology, Transcription Factors
وصف الملف: Hamaratoglu_deLachapelle.pdf - application/pdf; application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926b8294b19f0a06307f57d052d2ee96Test
https://www.zora.uzh.ch/id/eprint/78709Test/ -
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المؤلفون: Gary S. Stein, Larisa M. Haupt, Victor Nurcombe, Leong Fong Mei, Foong Kin Mun, Simon M. Cool, Andre J. Van Wijnen, Sadasivam Murali, Nadiya M. Teplyuk
المصدر: Journal of Cellular Physiology
مصطلحات موضوعية: Enzymologic, Time Factors, Physiology, Decorin, Clinical Biochemistry, Bone Morphogenetic Protein 2, Messenger/metabolism, Core Binding Factor Alpha 1 Subunit, Cell Differentiation/genetics, chemistry.chemical_compound, Mice, Versicans, Osteogenesis, Bone Morphogenetic Protein 2/metabolism, Receptors, Biglycan, Recombinant Proteins/metabolism, Regulation of gene expression, Mice, Knockout, Extracellular Matrix Proteins, Cell Differentiation, Heparan sulfate, 3T3 Cells, Fibroblast Growth Factor 2/metabolism, Recombinant Proteins, Cell biology, Protein Processing, Biochemistry, Fibroblast growth factor receptor, Versican, Cell Lineage/genetics, Fibroblast Growth Factor 2, Proteoglycans, RNA Interference, Sulfotransferases, Heparin Lyase/genetics/metabolism, 060103 Cell Development Proliferation and Death, Knockout, Biology, Transfection, Fibroblast Growth Factor/metabolism, Dermatan sulfate, Gene Expression Regulation, Enzymologic, Extracellular Matrix Proteins/metabolism, Glypicans/genetics/*metabolism, Osteogenesis/genetics, Glypicans, Animals, Humans, Heparanase, Cell Lineage, RNA, Messenger, Core Binding Factor Alpha 1 Subunit/genetics/metabolism, Cell Proliferation, Sulfotransferases/genetics/metabolism, Osteoblasts, Osteoblasts/enzymology/*metabolism, Post-Translational, Cell Biology, Proteoglycans/metabolism, Receptors, Fibroblast Growth Factor, carbohydrates (lipids), Gene Expression Regulation, chemistry, Heparin Lyase, biology.protein, RNA, Protein Processing, Post-Translational, Versicans/metabolism
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434707b9d0db1f12d0e358c0e356ba53Test
https://pubmed.ncbi.nlm.nih.gov/19479939Test -
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المؤلفون: Spiridon Gorezis, E. Tsanou, Niki J. Agnantis, Maria Stefaniotou, K. Psilas, Elli Ioachim
المصدر: European journal of ophthalmology. 15(3)
مصطلحات موضوعية: Proliferative vitreoretinopathy, Biological Markers/metabolism, Pigment Epithelium of Eye/metabolism/pathology, Collagen Type IV/biosynthesis/immunology, Severity of Illness Index, Extracellular matrix, 0302 clinical medicine, Laminin, Cell Movement, Immunohistochemistry/methods, Pigment Epithelium of Eye, Antigens/immunology, Epiretinal Membrane/etiology/*metabolism/pathology, Extracellular Matrix Proteins, biology, Glial fibrillary acidic protein, Extracellular Matrix Proteins/*metabolism, Glial Fibrillary Acidic Protein/biosynthesis/immunology, Cell Differentiation, Epiretinal Membrane, Tenascin, General Medicine, Immunohistochemistry, Cell biology, Vitreoretinopathy, Proliferative/complications/*metabolism/pathology, Membrane, Matrix Metalloproteinase 3, Collagen Type IV, Laminin/biosynthesis/immunology, 03 medical and health sciences, Glial Fibrillary Acidic Protein, medicine, Cell Adhesion, Humans, Antigens, Fibronectins/biosynthesis/immunology, Diabetic Retinopathy, Vitreoretinopathy, Proliferative, Tenascin/biosynthesis/immunology, medicine.disease, Matrix Metalloproteinase 3/biosynthesis/immunology, eye diseases, Fibronectins, Fibronectin, Ophthalmology, Diabetic Retinopathy/complications/*metabolism/pathology, Immunology, 030221 ophthalmology & optometry, biology.protein, Endothelium, Vascular, Wound healing, 030217 neurology & neurosurgery, Biomarkers, Endothelium, Vascular/metabolism/pathology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a68c5f67647bae621a8726c64b22616Test
https://pubmed.ncbi.nlm.nih.gov/15945009Test -
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المؤلفون: Beat A. Imhof, Martin Bastmeyer, Bernhard Wehrle-Haller, Ulrich Weiland, Christian David, Dirk Lehnert, Christoph Ballestrem
المصدر: Journal of Cell Science, Vol. 117, No Pt 1 (2004) pp. 41-52
مصطلحات موضوعية: Cell Size/ physiology, Integrin, Extracellular Matrix Proteins/ metabolism, ddc:616.07, Focal Adhesions/physiology, Microscopy, Atomic Force, Focal adhesion, Extracellular matrix, Mice, Cell Adhesion, Animals, Cell adhesion, Cytoskeleton, Cells, Cultured, Cell Size, Extracellular Matrix/ physiology, Extracellular Matrix Proteins, Focal Adhesions, biology, Cell Biology, Adhesion, 3T3 Cells, Immunohistochemistry, Cell biology, Extracellular Matrix, Rats, Surface coating, Cell Adhesion/ physiology, Microcontact printing, biology.protein, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31015dabbecdaf93401c9e647567f1d6Test
https://pubmed.ncbi.nlm.nih.gov/14657272Test -
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المؤلفون: David Deperthes, Takao Kataoka, Jürgen Engel, Jacqueline Romero, Nils Holler, Pedro Romero, Pascal Schneider, Jean-Luc Bodmer, Jürg Tschopp
المصدر: Journal of Immunological Methods, vol. 237, no. 1-2, pp. 159-173
مصطلحات موضوعية: Fas Ligand Protein, Recombinant Fusion Proteins, CD40 Ligand, Immunology, Receptors, Fc, Cartilage Oligomeric Matrix Protein, Ligands, Lymphocyte Activation, Jurkat cells, Receptors, Tumor Necrosis Factor, Immunoglobulin G, Fas ligand, Jurkat Cells, Mice, Tumor Cells, Cultured, Animals, Humans, Matrilin Proteins, Immunology and Allergy, Avidity, fas Receptor, CD40 Antigens, Receptor, Glycoproteins, Mice, Knockout, Cartilage oligomeric matrix protein, B-Lymphocytes, Extracellular Matrix Proteins, Membrane Glycoproteins, CD40, biology, Chemistry, Virology, In vitro, Cell biology, Solubility, biology.protein, Antigens, CD40/metabolism, Antigens, CD95/metabolism, B-Lymphocytes/cytology, B-Lymphocytes/drug effects, Extracellular Matrix Proteins/genetics, Extracellular Matrix Proteins/metabolism, Glycoproteins/genetics, Glycoproteins/metabolism, Lymphocyte Activation/drug effects, Membrane Glycoproteins/antagonists & inhibitors, Membrane Glycoproteins/metabolism, Receptors, Fc/genetics, Receptors, Fc/metabolism, Receptors, Tumor Necrosis Factor/genetics, Receptors, Tumor Necrosis Factor/metabolism, Recombinant Fusion Proteins/genetics, Recombinant Fusion Proteins/metabolism
وصف الملف: application/pdf
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https://serval.unil.ch/notice/serval:BIB_69A67AAF39A6Test -
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المؤلفون: B. Wehrle, Matthias Chiquet
المصدر: Development, Vol. 110, No 2 (1990) pp. 401-15
Europe PubMed Centralمصطلحات موضوعية: endocrine system, animal structures, Forelimb/innervation, Neurite, Laminin/pharmacology, Cell Adhesion Molecules, Neuronal, Cells, Morphogenesis, Tenascin, Chick Embryo, Fibronectins/pharmacology, Antibodies, Extracellular Matrix Proteins/metabolism, Extracellular matrix, Culture Techniques, Fibroblasts/physiology, Neurons/metabolism/ultrastructure, Peripheral Nerves/embryology/metabolism, Forelimb, Monoclonal, medicine, Neurites, Animals, Peripheral Nerves, Axon, Growth cone, Molecular Biology, Cells, Cultured, Neurons, Plexus, Extracellular Matrix Proteins, Cultured, biology, Antibodies, Monoclonal, Anatomy, Fibroblasts, Spinal cord, musculoskeletal system, Cell biology, Fibronectins, medicine.anatomical_structure, Neurites/metabolism/ultrastructure, embryonic structures, biology.protein, Neuronal/metabolism, Laminin, Cell Adhesion Molecules, Developmental Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4864ca2b305acfa0f9310e26e5f4d2Test
https://archive-ouverte.unige.ch/unige:26112Test