التفاصيل البيبلوغرافية
| العنوان: |
Optic nerve changes in chronic sinusitis patients: Correlation with disease severity and relevant sinus location. |
| المؤلفون: |
Kim, Young Hyo, Kim, Joseph, Kang, Min Gu, Lee, Dae Hyung, Chin, Hee Seung, Jang, Tae Young, Kim, Na Rae |
| المصدر: |
PLoS ONE; 7/10/2018, Vol. 13 Issue 7, p1-14, 14p |
| مصطلحات موضوعية: |
SINUSITIS, OPTIC nerve, STATISTICAL correlation, ACQUISITION of data, OPTICAL coherence tomography, PATIENTS |
| مستخلص: |
Purpose: This study was to evaluate whether optic nerve damage occurs in eyes with adjacent chronic sinusitis. Methods: Data were collected from eighty-eight eyes of 46 chronic sinusitis patients and 93 eyes of 57 normal controls. Visual sensitivity using standard automated perimetry (SAP) and inner retinal thickness using optical coherence tomography (OCT) were measured. The Lund-Mackay system was used to quantify radiographic findings on the ostiomeatal unit CT scan with a numerical score representing the severity of sinusitis. Results: There was a significant positive correlation between the pattern standard deviation (dB) and Lund-Mackay score (P = 0.031). Nasal retinal nerve fiber layer (RNFL) thickness, average, minimum, superotemporal, superior, superonasal, and inferonasal ganglion cell-inner plexiform layer (GCIPL) thickness were negatively correlated significantly with Lund-Mackay score (all, P < 0.05). Eyes with grade 2 opacification of the posterior ethmoid sinus showed a significantly lower mean deviation (dB) and higher pattern standard deviation (dB) than those with clear respective sinuses (P = 0.007 and <0.001, respectively). Eyes with grades 1,2 and 3 opacification of the sphenoid sinus had a significantly less average RNFL thickness (P = 0.004, <0.001, and <0.001, respectively) and a significantly less average GCIPL thickness (P = 0.004, 0.003, and 0.003, respectively) than those with a clear sphenoid sinus. Conclusions: Structural and functional optic nerve changes were correlated with the severity of chronic sinusitis. Inflammation of the posterior ethmoid and sphenoid sinuses was associated with optic nerve changes to a greater extent than that of the other paranasal sinuses. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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