المؤلفون: Ling Chen, Ya Wang, Guoxi Li, Qi Wan, Tingting Di, Huanxian Chang, Wenfeng Yu, Xianying Zeng

المصدر: Neurobiology of Disease, Vol 127, Iss, Pp 350-361 (2019)

مصطلحات موضوعية: 0301 basic medicine, BSCL2, Tau protein, Hyperphosphorylation, tau Proteins, Tau phosphorylation, Hippocampus, Protein Aggregation, Pathological, Seipin, lcsh:RC321-571, Congenital generalized lipodystrophy, 03 medical and health sciences, Mice, 0302 clinical medicine, GTP-Binding Protein gamma Subunits, Peroxisome proliferator-activated receptor-γ (PPARγ), medicine, Animals, Phosphorylation, Protein kinase B, Mammalian target of rapamycin (mTOR), lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, PI3K/AKT/mTOR pathway, Mice, Knockout, Neurons, Glycogen Synthase Kinase 3 beta, biology, Chemistry, TOR Serine-Threonine Kinases, GSK3β, Insulin resistance, medicine.disease, Axons, Cell biology, PPAR gamma, 030104 developmental biology, Neurology, biology.protein, Proto-Oncogene Proteins c-akt, 030217 neurology & neurosurgery, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e9c26c8af25986e1d0768233a2ccb9Test
http://www.sciencedirect.com/science/article/pii/S0969996119300762Test

المؤلفون: Yukari Kyumoto-Nakamura, Kento Nishida, Soichiro Sonoda, Sara Murata, Shion Hama, Toshio Kukita, Takayoshi Yamaza, Haruyoshi Yamaza, Kazuaki Nonaka, Yosuke Tanaka, Norihisa Uehara

المصدر: Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-12 (2018)

مصطلحات موضوعية: Male, 0301 basic medicine, Small interfering RNA, Bone Regeneration, Cell, Medicine (miscellaneous), Mice, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Osteogenesis, lcsh:QD415-436, Phosphorylation, lcsh:R5-920, biology, Chemistry, Cell Differentiation, Phosphoinositide 3 kinase (PI3K), Up-Regulation, Cell biology, medicine.anatomical_structure, Molecular Medicine, Stem cell, lcsh:Medicine (General), Signal Transduction, Scaffold-free spheroidal calcified construct, Stem cells from apical papilla (SCAP), Biochemistry, Genetics and Molecular Biology (miscellaneous), lcsh:Biochemistry, Young Adult, 03 medical and health sciences, Spheroids, Cellular, medicine, Animals, Humans, Mammalian target of rapamycin (mTOR), Dental Papilla, Protein kinase B, PI3K/AKT/mTOR pathway, Sirolimus, Phosphoinositide 3-kinase, Research, AKT, Multipotent Stem Cells, Regeneration (biology), Mesenchymal stem cell, Mesenchymal Stem Cells, 030206 dentistry, Cell Biology, Dentinogenesis, 030104 developmental biology, Dentin, biology.protein, Proto-Oncogene Proteins c-akt

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da87115e32aceab171d86993f9bb56bTest
https://doi.org/10.1186/s13287-018-1077-9Test

المؤلفون: José L. Quiles, Ángel J. De la Rosa, José L. Mauriz, Francisco J. Padillo, Raúl González, José M. Fuentes, Jesús de la Cruz, Javier González-Gallego, Elena Navarro-Villarán, Raquel Ordóñez, L.M. Marín-Gómez, Jordi Muntané, Mario Rodríguez-Arribas, María A. Rodríguez-Hernández, J.M. Álamo-Martínez, Paloma Gallego, Laura Contreras, José A Del Campo

المساهمون: Universidad de Sevilla. Departamento de Genética

المصدر: idUS. Depósito de Investigación de la Universidad de Sevilla
instname

مصطلحات موضوعية: 0301 basic medicine, Sorafenib, Cell signaling, autophagy, Physiology, Clinical Biochemistry, Apoptosis, 03 medical and health sciences, Mice, 0302 clinical medicine, Downregulation and upregulation, Autophagy, medicine, Biomarkers, Tumor, Animals, Humans, Bcl-2, Protein kinase A, Protein kinase B, PI3K/AKT/mTOR pathway, Chemistry, Caspase 3, mammalian target of rapamycin (mTOR), Liver Neoplasms, apoptosis, JNK Mitogen-Activated Protein Kinases, Cell Biology, Hep G2 Cells, Endoplasmic Reticulum Stress, 5′AMP-activated protein kinase (AMPK), Xenograft Model Antitumor Assays, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, 030104 developmental biology, 030220 oncology & carcinogenesis, Unfolded protein response, Cancer research, Myeloid Cell Leukemia Sequence 1 Protein, Transcription Factor CHOP, medicine.drug, Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13faddb9a0c020090635a3ed453ddd5eTest
https://hdl.handle.net/10668/12863Test

المؤلفون: Ji Miao, Sudha B. Biddinger, Ivana Semova, Anthony N. Hollenberg, Hong Kang, Matthew D. Hirschey, David Masson, Yue Hu, Satyapal Chahar, Xiaowei Sun

المساهمون: Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Harvard Medical School [Boston] ( HMS ), Beth Israel Deaconess Medical Center, Lipides - Nutrition - Cancer [Dijon - U1231] ( LNC ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Duke University Medical Center

المصدر: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2018, 293 (6), pp.2006-2014. 〈http://www.jbc.org/content/293/6/2006.longTest〉. 〈10.1074/jbc.M117.782557〉

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, mTORC1, Mechanistic Target of Rapamycin Complex 1, Biochemistry, metabolic syndrome, fructose, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Internal medicine, Gene expression, medicine, Animals, glucose, Molecular Biology, [ SDV.BBM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Triglycerides, lipogenesis, Mice, Knockout, Fatty liver, dyslipidemia, mammalian target of rapamycin (mTOR), Lipid metabolism, Fructose, Cell Biology, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Metabolism, chemistry, Gene Expression Regulation, Liver, Lipogenesis, Metabolic syndrome, Signal transduction, biological phenomena, cell phenomena, and immunity, 030217 neurology & neurosurgery, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0151552b633fb1a9d27448adf7dd3bTest
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01730773Test

المؤلفون: Weiping Wang, Kangtao Ma, Yinan Liu, Chunyan Zhou, Qin Lu, Ping Chen, Yang Wang, Zhe Yang, Tao Li, Yuyao Tian, Zhuqing Jia

المصدر: Bioscience Reports

مصطلحات موضوعية: 0301 basic medicine, Biophysics, Notch signaling pathway, cardiomyocytes, Biology, Fibroblast growth factor, Biochemistry, Bone morphogenetic protein 2, Cell Line, 03 medical and health sciences, Mice, Animals, Myocytes, Cardiac, Molecular Biology, PI3K/AKT/mTOR pathway, Research Articles, Sirolimus, FGF10, rapamycin, mammalian target of rapamycin (mTOR), Wnt signaling pathway, Cell Differentiation, Mouse Embryonic Stem Cells, Cell Biology, embryonic stem cells, Ascorbic acid, Molecular biology, Embryonic stem cell, Antigens, Differentiation, Cell biology, 030104 developmental biology, Gene Expression Regulation, embryonic structures, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb5ac3d69fd5fc28f1d2291d0abf91aTest
https://pubmed.ncbi.nlm.nih.gov/28396518Test

المؤلفون: Laura Sancillo, Rosa Alba Rana, Francesca Masiello, Fabrizio Martelli, Giovanni Barosi, Maria Zingariello, Judith D. Goldberg, Xiaochun Li, Fiorella Ciaffoni, Margherita Massa, Anna Rita Migliaccio, Barbara Ghinassi, Emanuela D'Amore

المساهمون: Zingariello, M, Martelli, F, Ciaffoni, F, Masiello, F, Ghinassi, B, D'Amore, E, Massa, M, Barosi, G, Sancillo, L, Li, X, Goldberg, Jd, Rana, Ra, Franco Migliaccio, Anna Rita

المصدر: Blood. 121:3345-3363

مصطلحات موضوعية: Adult, Male, Vascular Endothelial Growth Factor A, Hematopoiesis and Stem Cells, Blotting, Western, Immunology, Spleen, Biology, Real-Time Polymerase Chain Reaction, Primary myelofibrosis (PMF) is characterized by fibrosis, ineffective hematopoiesis in marrow, and hematopoiesis in extramedullary sites and is associated with abnormal megakaryocyte (MK) development and increased transforming growth factor (TGF)-β1 release. To clarify the role of TGF-β1 in the pathogenesis of this disease, the TGF-β1 signaling pathway of marrow and spleen of the Gata1(low) mouse model of myelofibrosis (MF) was profiled and the consequences of inhibition of TGF-β1 signaling on disease manifestations determined. The expression of 20 genes in marrow and 36 genes in spleen of Gata1(low) mice was altered. David-pathway analyses identified alterations of TGF-β1, Hedgehog, and p53 signaling in marrow and spleen and of mammalian target of rapamycin (mTOR) in spleen only and predicted that these alterations would induce consequences consistent with the Gata1(low) phenotype (increased apoptosis and G1 arrest both in marrow and spleen and increased osteoblast differentiation and reduced ubiquitin-mediated proteolysis in marrow only). Inhibition of TGF-β1 signaling normalized the expression of p53-related genes, restoring hematopoiesis and MK development and reducing fibrosis, neovascularization, and osteogenesis in marrow. It also normalized p53/mTOR/Hedgehog-related genes in spleen, reducing extramedullary hematopoiesis. These data identify altered expression signatures of TGF-β1 signaling that may be responsible for MF in Gata1(low) mice and may represent additional targets for therapeutic intervention in PMF, Biochemistry, Transforming Growth Factor beta1, Mice, Bone Marrow, Fibrosis, Biomarkers, Tumor, medicine, Animals, Humans, GATA1 Transcription Factor, RNA, Messenger, RNA, Small Interfering, Myelofibrosis, PI3K/AKT/mTOR pathway, Oligonucleotide Array Sequence Analysis, Ineffective Hematopoiesis, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, TOR Serine-Threonine Kinases, Cell Biology, Hematology, Middle Aged, Flow Cytometry, medicine.disease, Chemokine CXCL12, Extramedullary hematopoiesis, Disease Models, Animal, Haematopoiesis, medicine.anatomical_structure, Primary Myelofibrosis, Case-Control Studies, Cancer research, Cytokines, Bone marrow, Signal Transduction

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c708320f0f269d9717c1cd36e3eb8bcTest
https://doi.org/10.1182/blood-2012-06-439661Test

المؤلفون: Wee Kiat Ong, Greg C. Smith, Gordon W. Rewcastle, Peter R. Shepherd, Weiping Han, Jackie D. Kendall

المصدر: Biochemical Journal

مصطلحات موضوعية: Male, Pyridines, medicine.medical_treatment, phosphoinositide 3-kinase catalytic α polypeptide (PIK3CA), LC-MS/MS, liquid chromatography tandem MS, Biochemistry, phosphoinositide 3-kinase (PI3K), BMR, basal metabolic rate, Eating, Mice, PI3KCA, PI3K catalytic α polypeptide, Enzyme Inhibitors, media_common, Phosphoinositide-3 Kinase Inhibitors, ATM, ataxia telangiectasia mutated, Sulfonamides, TOR Serine-Threonine Kinases, mammalian target of rapamycin (mTOR), Imidazoles, Isoenzymes, PIKK, phosphoinositide kinase-related kinase, KI, knockin, Quinolines, GTT, glucose tolerance test, PI3K, phosphoinositide 3-kinase, Research Article, Gene isoform, medicine.medical_specialty, insulin, Class I Phosphatidylinositol 3-Kinases, media_common.quotation_subject, glucose metabolism, mTOR, mammalian target of rapamycin, P110α, Biology, Carbohydrate metabolism, Motor Activity, In vivo, Internal medicine, medicine, Animals, Furans, Molecular Biology, PI3K/AKT/mTOR pathway, ITT, insulin tolerance test, PTT, pyruvate tolerance test, KO, knockout, Insulin, Hydrazones, Appetite, Cell Biology, Endocrinology, Glucose, Pyrimidines, P110δ

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820523a0345782a3ea5f0b2738bc7a43Test
http://europepmc.org/articles/PMC3343648Test

المؤلفون: Woo-Jeong Lee, Sharada Kolekar, Christina M. Buchanan, Peter R. Shepherd, Stephen M. F. Jamieson, Jack U. Flanagan, Jackie D. Kendall, William A. Denny, Ripudaman Singh, James M. J. Dickson, Bruce C. Baguley, Gordon W. Rewcastle

المصدر: Biochemical Journal

مصطلحات موضوعية: PTEN, phosphatase and tensin homologue deleted on chromosome 10, PKB, protein kinase B, medicine.medical_treatment, TGI, tumour growth inhibition, BID, twice daily dosing, p110α E545K mutation, mTOR, mammalian target of rapamycin, ERK, extracellular-signal-regulated kinase, Biochemistry, Mice, Tumor Cells, Cultured, medicine, Animals, Humans, Protein Isoforms, Tensin, PTEN, Tissue Distribution, Enzyme Inhibitors, pan-phosphoinositide 3kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235, phosphoinositide 3-kinase α (PI3Kα), Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Homeodomain Proteins, Mice, Knockout, Phosphoinositide 3-kinase, biology, QD, once daily dosing, Growth factor, PIK3CA, Neoplasms, Experimental, Cell Biology, phosphoinositide 4-kinase (PI4K), PIK3CA H1047R mutation, PI4K, phosphoinositide 4-kinase, Cell biology, Class Ia Phosphatidylinositol 3-Kinase, P110δ, biology.protein, Signal transduction, Proto-Oncogene Proteins c-akt, PI3K, phosphoinositide 3-kinase, Research Article, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1a7d1444366d807c36dc5923f61ac0Test
https://doi.org/10.1042/bj20110502Test

المؤلفون: Ming‑Xu Hu, Li Liu, Rui‑Hong Zhang, Ping Zhang, Ke‑Li Yun, Hong‑Cai Zhang, Li Sui

المصدر: Bioscience Reports, Vol 35, Iss 2, p e00186 (2015)
Bioscience Reports

مصطلحات موضوعية: Programmed cell death, autophagy, Biophysics, lcsh:Life, lcsh:QR1-502, endoplasmic reticulum (ER) stress, Metal toxicity, mTOR, mammalian target of rapamycin, mTORC1, Mechanistic Target of Rapamycin Complex 1, Pharmacology, Biology, Biochemistry, lcsh:Microbiology, ER, endoplasmic reticulum, Mice, ROS, reactive oxygen species, UPR, unfolded protein response, mammalian target of rapamycin (mTOR) pathway, S6K1, S6 kinase 1, Animals, Humans, Molecular Biology, Cells, Cultured, DMEM, Dulbecco's Modified Essential Medium, Original Paper, Myocardium, TOR Serine-Threonine Kinases, Endoplasmic reticulum, Autophagy, mTORC1, mammalian target of rapamycin complex 1, Cell Biology, Fibroblasts, lead toxicity, LC3, light chain 3, Cell biology, lcsh:QH501-531, Lead, Apoptosis, Multiprotein Complexes, Toxicity, Unfolded protein response, 3-MA, 3-methyladenine, cardiofibroblasts

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b99c3e54419619f587d1db7268a04f5Test
http://www.bioscirep.org/bsr/035/e186/bsr035e186.htmTest

المؤلفون: Paola Muti, Gregory R. Steinberg, Bruce E. Kemp, Andrew J. O'Brien, Vanessa P. Houde, Linda Villani, Theodoros Tsakiridis, Giovanni Blandino, Sandra Galic, Lindsay A. Broadfield

مصطلحات موضوعية: Male, Lung Neoplasms, Sodium Salicylate, AMP-Activated Protein Kinases, Biochemistry, chemistry.chemical_compound, Mice, AMP-activated protein kinase, Mice, Knockout, Aspirin, biology, Anti-Inflammatory Agents, Non-Steroidal, mammalian target of rapamycin (mTOR), Drug Synergism, Metformin, Neoplasm Proteins, Lipogenesis, Female, medicine.drug, acetyl-CoA carboxylase (ACC), medicine.medical_specialty, Cell Survival, aspirin, proliferation, fatty acids, Internal medicine, Cell Line, Tumor, medicine, Animals, Humans, Hypoglycemic Agents, Protein kinase A, Molecular Biology, Sodium salicylate, Fatty acid synthesis, Binding Sites, AMPK, Prostatic Neoplasms, cholesterol, Cell Biology, Fibroblasts, Embryo, Mammalian, Enzyme Activation, Endocrinology, chemistry, biology.protein, Cancer research, 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase, Acetyl-CoA Carboxylase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69fa08a800d2106d31457a94d70f7df9Test
https://acuresearchbank.acu.edu.au/item/8825v/salicylate-activates-ampk-and-synergizes-with-metformin-to-reduce-the-survival-of-prostate-and-lung-cancer-cells-ex-vivo-through-inhibition-of-de-novo-lipogenesisTest