Galectin-1, an alternative signal for T cell death, is increased in activated macrophages
| العنوان: | Galectin-1, an alternative signal for T cell death, is increased in activated macrophages |
|---|---|
| المؤلفون: | Gabriel A. Rabinovich, Claudia Elena Sotomayor, Clelia M. Riera |
| المصدر: | Brazilian Journal of Medical and Biological Research v.32 n.5 1999 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Vol 32, Iss 5, Pp 557-567 (1999) Brazilian Journal of Medical and Biological Research, Vol 32, Iss 5, p 557 (1999) Brazilian Journal of Medical and Biological Research, Volume: 32, Issue: 5, Pages: 557-567, Published: MAY 1999 |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Galectin 1, Physiology, T cell, T-Lymphocytes, Immunology, Biophysics, Context (language use), Thymus Gland, macrophage, Biology, immunomodulation, Biochemistry, Immune tolerance, Immune system, medicine, Immune Tolerance, Leukocytes, otorhinolaryngologic diseases, Macrophage, Animals, Homeostasis, galectin-1, General Pharmacology, Toxicology and Pharmaceutics, lcsh:QH301-705.5, Galectin, lcsh:R5-920, Glycobiology, General Neuroscience, Macrophages, apoptosis, Epithelial Cells, Cell Biology, General Medicine, Cell biology, medicine.anatomical_structure, Hemagglutinins, lcsh:Biology (General), Immune System, Galectin-1, lcsh:Medicine (General) |
| الوصف: | Galectin-1 belongs to an evolutionarily conserved family of animal beta-galactoside-binding proteins, which exert their functions by crosslinking the oligosaccharides of specific glycoconjugate ligands. During the past decade, attempts to identify the functional role of galectin-1 suggested participation in the regulation of the immune response. Only in the last few years has the molecular mechanism involved in these properties been clearly elucidated, revealing a critical role for galectin-1 as an alternative signal in the generation of T cell death. In the present study we will discuss the latest advances in galectin research in the context of the regulation of the immune response, not only at the central level but also at the periphery. Moreover, we will review the purification, biochemical properties and functional significance of a novel galectin-1-like protein from activated rat macrophages, whose expression is differentially regulated according to the activation state of the cells. The novel role of a carbohydrate-binding protein in the regulation of apoptosis is providing a breakthrough in galectin research and extending the interface between immunology, glycobiology and clinical medicine. |
| وصف الملف: | text/html |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002d73e367b7d98c349431566de2ebf5Test http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500009Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....002d73e367b7d98c349431566de2ebf5 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |