The NEMP family supports metazoan fertility and nuclear envelope stiffness
| العنوان: | The NEMP family supports metazoan fertility and nuclear envelope stiffness |
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| المؤلفون: | Andrea Jurisicova, Yonit Tsatskis, Rod Bremner, John R. B. Perry, Kyunga Kim, Brian Ciruna, Daniel Potter, Dorothea Godt, Wade H. Dunham, Yu Sun, Michael I. Robson, Shu Wu, Robyn Rosenfeld, Julie A. Brill, Karen Krchma, Tim Schedl, Anne-Claude Gingras, Joel Pearson, Curtis W. Boswell, Helen McNeill, Kyunghee Choi, Laurence Pelletier, Didier Hodzic, Jin Meng, Lacramioara Fabian, Yi Qu, Ariz Mohammad, Eric C. Schirmer, João Gonçalves, Jun Wu, Xian Wang |
| المساهمون: | Tsatskis, Yonit [0000-0003-2580-0728], Rosenfeld, Robyn [0000-0001-6853-2036], Qu, Yi [0000-0002-1420-7753], Kim, Kyunga [0000-0003-3218-5081], Mohammad, Ariz [0000-0002-2807-412X], Wang, Xian [0000-0002-1501-2544], Robson, Michael I [0000-0003-1126-3538], Gonçalves, João [0000-0001-5329-0986], Hodzic, Didier [0000-0002-2113-8936], Gingras, Anne-Claude [0000-0002-6090-4437], Sun, Yu [0000-0001-7895-0741], Godt, Dorothea [0000-0003-3821-5181], Schedl, Tim [0000-0003-2148-2996], Ciruna, Brian [0000-0001-7918-0953], Choi, Kyunghee [0000-0002-9634-9375], Perry, John RB [0000-0001-6483-3771], Bremner, Rod [0000-0001-9184-7212], Schirmer, Eric C [0000-0003-2635-1338], Brill, Julie A [0000-0002-5925-9901], Jurisicova, Andrea [0000-0003-2166-4298], McNeill, Helen [0000-0003-1126-5154], Apollo - University of Cambridge Repository |
| المصدر: | Science Advances Tsatskis, Y, Rosenfeld, R, Pearson, J D, Boswell, C, Qu, Y, Kim, K, Fabian, L, Mohammed, A, Wang, X, Robson, M, Krchma, K, Wu, J, Gonçalves, J, Hodzic, D, Wu, S, Potter, D, Pelletier, L, Dunham, W H, Gingras, A-C, Sun, Y, Meng, J, Godt, D, Schedl, T, Ciruna, B, Choi, K, Perry, J R B, Bremner, R, Schirmer, E C, Brill, J A, Jurisicova, A & McNeill, H 2020, ' The NEMP family supports metazoan fertility and nuclear envelope stiffness ', Science Advances, vol. 6, eabb4591 . https://doi.org/10.1126/sciadv.abb4591Test |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Aging, Sterility, media_common.quotation_subject, 1.1 Normal biological development and functioning, Fertility, 3101 Biochemistry and Cell Biology, Germline, 3105 Genetics, 03 medical and health sciences, Homologous chromosome, Genetics, 1 Underpinning research, Zebrafish, Caenorhabditis elegans, Research Articles, 030304 developmental biology, media_common, Genetic association, 0303 health sciences, Multidisciplinary, biology, Contraception/Reproduction, 030302 biochemistry & molecular biology, Human Genome, SciAdv r-articles, biology.organism_classification, Cell biology, Membrane protein, FOS: Biological sciences, Generic health relevance, Research Article, 31 Biological Sciences, Biotechnology |
| الوصف: | Loss of Nemp leads to softening of the germline nuclear envelope and loss of fertility. Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in NEMP1 (nuclear envelope membrane protein 1) with early menopause; however, it is unclear whether NEMP1 has any role in fertility. We show that whole-animal loss of NEMP1 homologs in Drosophila, Caenorhabditis elegans, zebrafish, and mice leads to sterility or early loss of fertility. Loss of Nemp leads to nuclear shaping defects, most prominently in the germ line. Biochemical, biophysical, and genetic studies reveal that NEMP proteins support the mechanical stiffness of the germline nuclear envelope via formation of a NEMP-EMERIN complex. These data indicate that the germline nuclear envelope has specialized mechanical properties and that NEMP proteins play essential and conserved roles in fertility. |
| وصف الملف: | application/pdf |
| DOI: | 10.17863/cam.58427 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526b5f096f3c9b8dfa6e5d0b8a6b78ddTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....526b5f096f3c9b8dfa6e5d0b8a6b78dd |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.17863/cam.58427 |
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