Beyond autophagy: the expanding roles of ATG8 proteins
| العنوان: | Beyond autophagy: the expanding roles of ATG8 proteins |
|---|---|
| المؤلفون: | Andrew M. Leidal, Jayanta Debnath, Jose L. Nieto-Torres, Malene Hansen |
| المصدر: | Trends Biochem Sci Trends in biochemical sciences, vol 46, iss 8 |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Autophagosome, Autophagy-Related Protein 8 Family, 1.1 Normal biological development and functioning, ATG8, GABARAP, Autophagy-Related Proteins, Biology, Medical and Health Sciences, Biochemistry, Article, 03 medical and health sciences, 0302 clinical medicine, unconventional secretion, Underpinning research, Organelle, LC3, Autophagy, Molecular Biology, 030304 developmental biology, non-canonical autophagy, 0303 health sciences, Vesicle, Autophagosomes, Biological Sciences, multivesicular bodies, LC3-associated phagocytosis, Cell biology, Chemical Sciences, Generic health relevance, Lysosomes, Microtubule-Associated Proteins, 030217 neurology & neurosurgery, Biogenesis, Developmental Biology |
| الوصف: | The ATG8 family proteins are critical players in autophagy, a cytoprotective process that mediates degradation of cytosolic cargo. During autophagy, ATG8s conjugate to autophagosome membranes to facilitate cargo recruitment, autophagosome biogenesis, transport, and fusion with lysosomes, for cargo degradation. In addition to these canonical functions, recent reports demonstrate that ATG8s are also delivered to single-membrane organelles, which leads to highly divergent degradative or secretory fates, vesicle maturation, and cargo specification. The association of ATG8s with different vesicles involves complex regulatory mechanisms still to be fully elucidated. Whether individual ATG8 family members play unique canonical or non-canonical roles, also remains unclear. This review summarizes the many open molecular questions regarding ATG8s that are only beginning to be unraveled. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcdbe565030f5da2e4bd98f94724cf88Test https://europepmc.org/articles/PMC8286281Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bcdbe565030f5da2e4bd98f94724cf88 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |