Glucocorticoids Stimulate the Accumulation of Lipids in the Rat Corpus Luteum1
| العنوان: | Glucocorticoids Stimulate the Accumulation of Lipids in the Rat Corpus Luteum1 |
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| المؤلفون: | A. M. Silverstein, J. M. Cohen, Jennifer M. Bowen, P L Keyes, R K Brabec, K.M.J. Menon, Roberto Towns |
| المصدر: | Biology of Reproduction. 61:416-421 |
| بيانات النشر: | Oxford University Press (OUP), 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | endocrine system, medicine.medical_specialty, Hypophysectomy, urogenital system, medicine.medical_treatment, Ovary, Cell Biology, General Medicine, Biology, Luteal phase, chemistry.chemical_compound, Endocrinology, medicine.anatomical_structure, Glucocorticoid receptor, Reproductive Medicine, chemistry, Corticosterone, Internal medicine, medicine, Corpus luteum, reproductive and urinary physiology, hormones, hormone substitutes, and hormone antagonists, Glucocorticoid, Dexamethasone, medicine.drug |
| الوصف: | We investigated the physiological basis for the trophic effect of glucocorticoids in rat corpora lutea in the absence of pituitary gonadotropins. Immature (Day 29) Sprague-Dawley rats were given eCG and hCG to induce the development of corpora lutea and were hypophysectomized on Day 32. Beginning on Day 40, rats received twice-daily s.c. injections of either dexamethasone (dex; 200 microg/rat/day) or vehicle (controls) and then were killed on Day 44. Plasma 20alpha-dihydroprogesterone, a major steroid produced by the corpora lutea, was higher (p 2-fold of plasma 20alpha-dihydroprogesterone concentration compared to controls. Glucocorticoid receptor protein (about 92 kDa) was detected in both luteal and nonluteal ovarian tissues in this animal model. These effects of glucocorticoids and the presence of the glucocorticoid receptor raise the possibility of a physiological role for glucocorticoids in the rat corpus luteum. |
| تدمد: | 1529-7268 0006-3363 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::57c29bd6dcf9621f9c6dee61f9167857Test https://doi.org/10.1095/biolreprod61.2.416Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........57c29bd6dcf9621f9c6dee61f9167857 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15297268 00063363 |
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