Acid sphingomyelinase in macrophage biology
| العنوان: | Acid sphingomyelinase in macrophage biology |
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| المؤلفون: | Mohammed M. Al Gadban, Jean-Philip Truman, Kent J. Smith, Samar M. Hammad |
| المصدر: | Cellular and Molecular Life Sciences. 68:3293-3305 |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Ceramide, Biology, Sphingomyelin phosphodiesterase, Article, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Lysosome, medicine, Animals, Humans, Macrophage, Molecular Biology, Tissue homeostasis, Pharmacology, Innate immune system, Macrophages, Cell Biology, Cell biology, Sphingomyelin Phosphodiesterase, medicine.anatomical_structure, Biochemistry, chemistry, Molecular Medicine, Acid sphingomyelinase, Sphingomyelin, medicine.drug |
| الوصف: | Macrophages play a central role in innate immune responses, in disposal of cholesterol, and in tissue homeostasis and remodeling. To perform these vital functions macrophages display high endosomal/lysosomal activities. Recent studies have highlighted that acid sphingomyelinase (ASMase), which generates ceramide from sphingomyelin, is involved in modulation of membrane structures and signal transduction in addition to its metabolic role in the lysosome. In this review, we bring together studies on ASMase, its different forms and locations that are necessary for the macrophage to accomplish its diverse functions. We also address the importance of ASMase to several disease processes that are mediated by activated macrophages. |
| تدمد: | 1420-9071 1420-682X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d049a3350554cb3b4f789e7514c28c8cTest https://doi.org/10.1007/s00018-011-0686-6Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d049a3350554cb3b4f789e7514c28c8c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14209071 1420682X |
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