التفاصيل البيبلوغرافية
| العنوان: |
Serological markers and HLA-DQ2 haplotype among first-degree relatives of celiac patients. Catalonian Coeliac Disease Study Group. |
| المؤلفون: |
Farré, C, Humbert, P, Vilar, P, Varea, V, Aldeguer, X, Carnicer, J, Carballo, M, Gassull, M A |
| المصدر: |
Digestive Diseases & Sciences; Nov1999, Vol. 44 Issue 11, p2344-2349, 6p |
| مصطلحات موضوعية: |
CELIAC disease, COMPARATIVE studies, DISEASE susceptibility, FAMILY health, GENEALOGY, GENETIC techniques, GLUTEN, IMMUNOGLOBULINS, RESEARCH methodology, MEDICAL cooperation, MUSCLES, RESEARCH, HLA-B27 antigen, EVALUATION research, DISEASE prevalence, HAPLOTYPES |
| مستخلص: |
Serologic markers, HLA-DQ2 haplotype, and clinical features suggestive of celiac disease were studied to assess their diagnostic value in a multicentric study to detect celiac disease in 675 first-degree relatives of 227 celiac probands. Serum IgA-class anti-endomysium and IgA-class anti-gliadin antibodies were positive in 5.8% and 1.9% of relatives, respectively. HLA-DQ2 haplotype was present in 64% of relatives, and the overall rate of celiac disease diagnosed by intestinal biopsy was 5.5%. The frequency of HLA-DQ2 in the celiac patients and controls was 93% and 18%, respectively. The most frequent clinical features--diarrhea, anemia, food intolerance, and growth retardation--were not present in one third of the celiac disease relatives. We conclude that the assessment of IgA-class anti-endomysium antibodies alone seems a reasonable approach for screening celiac disease in relatives and cannot be replaced by an accurate clinical anamnesis. HLA-DQ2 haplotype may identify the population with a high genetic susceptibility to celiac disease. [ABSTRACT FROM AUTHOR] |
|
Copyright of Digestive Diseases & Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
