دورية أكاديمية
أعرض في EDS

Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance

التفاصيل البيبلوغرافية
العنوان: Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance
المؤلفون: Botta, Cirino, Pérez Ruiz, Cristina, Larrayoz, Marta, Puig, Noemi, CEDENA, M TERESA, Termini , Rosalinda, Gironella, Mercedes
المساهمون: Institut Català de la Salut, Botta C Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy. Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), CCUN, Instituto de Investigacion Sanitaria de Navarra (IDISNA), CIBER-ONC numbers CB16/12/00369, CB16/12/00489, Pamplona, Spain. Perez C, Larrayoz M, Termini R Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), CCUN, Instituto de Investigacion Sanitaria de Navarra (IDISNA), CIBER-ONC numbers CB16/12/00369, CB16/12/00489, Pamplona, Spain. Puig N Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca (IBSAL), Centro de Investigación del Cancer (IBMCC-USAL, CSIC), CIBER-ONC number CB16/12/00233, Salamanca, Spain. Cedena MT Hospital Universitario 12 de Octubre, CIBER-ONC number CB16/12/00369, Madrid, Spain. Gironella M Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus
المصدر: Scientia
بيانات النشر: Nature Portfolio
سنة النشر: 2023
مصطلحات موضوعية: Mieloma múltiple - Tractament, Medicaments immunosupressors - Ús terapèutic, Cèl·lules T, DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Plasma Cell::Multiple Myeloma, Other subheadings::Other subheadings::Other subheadings::/drug therapy, ANATOMY::Cells::Cells, Cultured::Clone Cells, CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Immunologic Factors::Immunosuppressive Agents, Other subheadings::Other subheadings::/therapeutic use, ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de células plasmáticas::mieloma múltiple, Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia, ANATOMÍA::células::células cultivadas::células clonales, COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::efectos fisiológicos de los fármacos::factores inmunitarios::inmunosupresores, Otros calificadores::Otros calificadores::/uso terapéutico
الوصف: Large T cell; Immune checkpoints; Multiple myeloma ; Cèl·lules T grans; Punts de control immunitari; Mieloma múltiple ; Células T grandes; Puntos de control inmunitario; Mieloma múltiple ; Tumor recognition by T cells is essential for antitumor immunity. A comprehensive characterization of T cell diversity may be key to understanding the success of immunomodulatory drugs and failure of PD-1 blockade in tumors such as multiple myeloma (MM). Here, we use single-cell RNA and T cell receptor sequencing to characterize bone marrow T cells from healthy adults (n = 4) and patients with precursor (n = 8) and full-blown MM (n = 10). Large T cell clones from patients with MM expressed multiple immune checkpoints, suggesting a potentially dysfunctional phenotype. Dual targeting of PD-1 + LAG3 or PD-1 + TIGIT partially restored their function in mice with MM. We identify phenotypic hallmarks of large intratumoral T cell clones, and demonstrate that the CD27− and CD27+ T cell ratio, measured by flow cytometry, may serve as a surrogate of clonal T cell expansions and an independent prognostic factor in 543 patients with MM treated with lenalidomide-based treatment combinations. ; This work was supported by grants from the Instituto de Salud Carlos III/Subdireccion General de Investigacion Sanitaria and co-financed by FEDER funds (CB16/12/00233, CB16/12/00369, PI17/01243, PI19/00818 and PI20/00048), and together with Fundación Científica de la Asociación Española Contra el Cáncer (FCAECC) for iMMunocell Transcan-2 (AC17/00101), FCAECC Predoctoral Grant Junta Provincial Navarra, the Cancer Research UK (C355/A26819), FCAECC and Italian Association for Cancer Research (AIRC) under the Accelerator Award Program (EDITOR), 2017 Multiple Myeloma Research Foundation Immunotherapy Networks of Excellence, Black Swan Research Initiative of the International Myeloma Foundation, European Hematology Association nonclinical advanced research grant (3680644), European Research Council 2015 Starting Grant (MYELOMANEXT grant 680200), the Cancer ...
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
اللغة: English
تدمد: 2041-1723
العلاقة: Nature Communications;14; https://doi.org/10.1038/s41467-023-41562-6Test; Botta C, Perez C, Larrayoz M, Puig N, Cedena MT, Termini R, et al. Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance. Nat Commun. 2023 Sep 20;14:5825.; https://hdl.handle.net/11351/10359Test
DOI: 10.1038/s41467-023-41562-6
الإتاحة: https://doi.org/10.1038/s41467-023-41562-6Test
https://hdl.handle.net/11351/10359Test
حقوق: Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.8B3D25E1
قاعدة البيانات: BASE
الوصف
تدمد:20411723
DOI:10.1038/s41467-023-41562-6