دورية أكاديمية
Control of Immunoregulatory Molecules by miRNAs in T Cell Activation
| العنوان: | Control of Immunoregulatory Molecules by miRNAs in T Cell Activation |
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| المؤلفون: | Rodríguez-Galán, Ana, Fernández Messina, Lola María, Sánchez-Madrid, Francisco |
| بيانات النشر: | Frontiers Media |
| سنة النشر: | 2018 |
| المجموعة: | Universidad Complutense de Madrid (UCM): E-Prints Complutense |
| مصطلحات موضوعية: | 577.27, T cell activation, microRNAs (miRNAs), immunoregulatory molecules, miRNA signature, CD4, CD8, T lymphocyte, Biología celular (Biología), Biología molecular (Biología), Bioquímica (Biología), Inmunología, 2403 Bioquímica, 2407 Biología Celular, 2412 Inmunología, 2415 Biología Molecular |
| الوصف: | Acknowledgments We thank Dr M. Vicente-Manzanares for critical reading of the manuscript and for assistance with English editing. This study was supported by the following grants from the Spanish Ministry of Economy and Competitiveness, (grant SAF2017-82886-R to FSM), CIBER CARDIOVASCULAR and PIE 13.0004-BIOIMID from the Instituto de Salud Carlos III (Fondo de Investigación Sanitaria del Instituto de Salud Carlos III with co-funding from the Fondo Europeo de Desarrollo Regional; FEDER), Programa de Actividades en Biomedicina de la Comunidad de Madrid-B2017/BMD-3671-INFLAMUNE to FS-M, and ERC-2011-AdG294340-GENTRIS to FS-M. The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). AR-G is supported by the FPU program (Spanish Ministry of Education). LF-M is funded by the CIBER CARDIOVASCULAR. ; MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function is constrained by a specific spatiotemporal frame related to the signals that induce T cell-based effector functions. Here, we update the state of the art regarding the miRNAs that are differentially expressed during T cell stimulation. We also revisit the existing data on miRNA function in T cell activation, with a special focus on the modulation of the most relevant immunoregulatory molecules. ; Depto. de Biología Celular ; Fac. de Ciencias Biológicas ; TRUE ; pub |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1664-3224 |
| العلاقة: | SAF2017-82886-R; PIE 13.0004-BIOIMID; B2017/BMD-3671-INFLAMUNE; ERC-2011-AdG294340-GENTRIS; https://hdl.handle.net/20.500.14352/97122Test; https://www.frontiersin.org/articles/10.3389/fimmu.2018.02148/fullTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167432Test/ |
| DOI: | 10.3389/fimmu.2018.02148 |
| DOI: | 10.3389/fimmu.2018.02148/full |
| الإتاحة: | https://doi.org/20.500.14352/97122Test https://doi.org/10.3389/fimmu.2018.02148Test https://hdl.handle.net/20.500.14352/97122Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167432Test/ |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; open access |
| رقم الانضمام: | edsbas.CECBB3F2 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16643224 |
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| DOI: | 10.3389/fimmu.2018.02148 |