دورية أكاديمية
Firing up the cold tumors by targeting Vps34
| العنوان: | Firing up the cold tumors by targeting Vps34 |
|---|---|
| المؤلفون: | Bassam Janji, Meriem Hasmim, Santiago Parpal, Guy Berchem, Muhammad Zaeem Noman |
| المصدر: | OncoImmunology, Vol 9, Iss 1 (2020) |
| بيانات النشر: | Taylor & Francis Group, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Immunologic diseases. Allergy LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | autophagy, vps34, cold/hot tumors, proinflammatory cytokines, ccl5, cxcl10, immune landscape, nk cells, t cd8 lymphocytes, cancer immunotherapy, anti-pd-1/pd-l1, melanoma, colon cancer, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration. In our recent report published in Science Advances, we demonstrate that targeting the autophagy-related protein Vps34 switched cold immune desert tumors into hot inflamed immune-infiltrated tumors and enhanced the efficacy of anti-PD-1/PD-L1. Our study provides the preclinical rationale to set up combination immunotherapy clinical trials using selective Vps34 inhibitors and immune checkpoint blockers in melanoma and CRC. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2162-402X 2162402X |
| العلاقة: | https://doaj.org/toc/2162-402XTest |
| DOI: | 10.1080/2162402X.2020.1809936 |
| الوصول الحر: | https://doaj.org/article/b66f359dbbd9444c8f7c692b71fd8b94Test |
| رقم الانضمام: | edsdoj.b66f359dbbd9444c8f7c692b71fd8b94 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2162402X |
|---|---|
| DOI: | 10.1080/2162402X.2020.1809936 |