دورية أكاديمية
Fate of premalignant clones during the asymptomatic phase preceding lymphoid malignancy. Cancer Res 65:1234-43.
| العنوان: | Fate of premalignant clones during the asymptomatic phase preceding lymphoid malignancy. Cancer Res 65:1234-43. |
|---|---|
| المؤلفون: | Moules, V., Pomier, C., Sibon, D., Gabet, As, Reichert, M., Kerkhofs, P., Mortreux, F., Wattel, E., Willems, L. |
| المساهمون: | Virologie et pathogenèse virale (VPV), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Department of Pathology, National Veterinary Research Institute, Department of Virology, Veterinary, and Agrochemical Research Centre, Faculte Universitaire des Sciences Agronomiques, Faculte Universitaire des Sciences-Agronomiques, Received 5/25/2004, revised 11/30/2004, accepted 12/7/2004. Grant support: Ligue Nationale Contre le Cancer (e´quipe labellise´e, 2003), bursaries from Comite´ De´partemental de la Loire de la Ligue Nationale Contre le Cancer (V. Moule´s), Comite´ De´partemental de l'Ain de la Ligue Nationale Contre le Cancer (C. Pomier), Association Franc¸aise pour la Recherche sur le Cancer (D. Sibon), and Centre Le´on Be´rard (A-S. Gabet). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. We thank Denis Gerlier for fruitful discussions. |
| المصدر: | ISSN: 0008-5472. |
| بيانات النشر: | HAL CCSD American Association for Cancer Research |
| سنة النشر: | 2005 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | Animals, Cattle, Cell Transformation, Viral/physiology, Clone Cells, DNA, Neoplasm/genetics, Leukemia/genetics/*pathology/virology, Leukemia Virus, Bovine/genetics, Lymphoma/genetics/*pathology/virology, Mutation, Precancerous Conditions/genetics/*pathology/virology, Sheep, Sheep Diseases/virology, Virus Integration, OCIS 000.1430, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology |
| الوصف: | Almost all cancers are preceded by a prolonged period of clinical latency during which a combination of cellular events helps move carcinogen-exposed cells towards a malignant phenotype. Hitherto, investigating the fate of premalignant cells in vivo remained strongly hampered by the fact that these cells are usually indistinguishable from their normal counterparts. Here, for the first time, we have designed a strategy able to reconstitute the replicative history of the bona fide premalignant clone in an animal model, the sheep experimentally infected with the lymphotropic bovine leukemia virus. We have shown that premalignant clones are early and clearly distinguished from other virus-exposed cells on the basis of their degree of clonal expansion and genetic instability. Detectable as early as 0.5 month after the beginning of virus exposure, premalignant cells displayed a two-step pattern of extensive clonal expansion together with a mutation load approximately 6 times higher than that of other virus-exposed cells that remained untransformed during the life span of investigated animals. There was no fixation of somatic mutations over time, suggesting that they regularly lead to cellular death, partly contributing to maintain a normal lymphocyte count during the prolonged premalignant stage. This equilibrium was finally broken after a period of 18.5 to 60 months of clinical latency, when a dramatic decrease in the genetic instability of premalignant cells coincided with a rapid increase in lymphocyte count and lymphoma onset. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/15735007; hal-00124213; https://hal.science/hal-00124213Test; PUBMED: 15735007 |
| الإتاحة: | https://hal.science/hal-00124213Test |
| رقم الانضمام: | edsbas.73544162 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |