التفاصيل البيبلوغرافية
| العنوان: |
Protocol for measuring myocardial blood flow by PET/CT in cats. |
| المؤلفون: |
Jenni, Simone, Schepis, Tiziano, Jenni, Rolf, Siegrist, Patrick, Kaufmann, Philipp, Glaus, Tony |
| المصدر: |
European Journal of Nuclear Medicine & Molecular Imaging; Feb2009, Vol. 36 Issue 2, p244-249, 6p, 1 Chart, 2 Graphs |
| مصطلحات موضوعية: |
CORONARY circulation, BLOOD flow, BLOOD circulation, POSITRON emission tomography, TOMOGRAPHY |
| مستخلص: |
The aim of this study was to establish a protocol for measuring myocardial blood flow (MBF) by PET/CT in healthy cats. The rationale was its future use in Maine Coon cats with hypertrophic cardiomyopathy (HCM) as a model for human HCM. MBF was measured in nine anaesthetized healthy cats using a PET/CT scanner and 13NH3 at rest and during adenosine infusion. Each cat was randomly assigned to receive vasodilator stress with two or three adenosine infusions at the following rates (μg/kg per minute): 140 (Ado 1, standard rate for humans), 280 (Ado 2, twice the human standard rate), 560 (Ado 4), 840 (Ado 6) and 1,120 (Ado 8). The median MBF at rest was 1.26 ml/min per g ( n = 9; range 0.88–1.72 ml/min per g). There was no significant difference at Ado 1 ( n = 3; median 1.35, range 0.93–1.55 ml/min per g; ns) but MBF was significantly greater at Ado 2 ( n = 6; 2.16, range 1.35–2.68 ml/min per g; p < 0.05) and Ado 4 ( n = 6; 2.11, 1.92–2.45 ml/min per g; p < 0.05). Large ranges of MBF values at Ado 6 ( n = 4; 2.53, 2.32–5.63 ml/min per g; ns) and Ado 8 ( n = 3; 2.21, 1.92–5.70 ml/min per g; ns) were noted. Observed adverse effects, including hypotension, AV-block and ventricular premature contractions, were all mild, of short duration and immediately reversed after cessation of the adenosine infusion. MBF can be safely measured in cats using PET. An intravenous adenosine infusion at a rate of 280 μg/kg per minute seems most appropriate to induce maximal hyperaemic MBF response in healthy cats. Higher adenosine rates appear less suitable as they are associated with a large heterogeneity in flow increase and rate pressure product, most probably due to the large variability in haemodynamic and heart rate response. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
