كتاب
Systems Biology Approaches to the Study of Apoptosis
| العنوان: | Systems Biology Approaches to the Study of Apoptosis |
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| المؤلفون: | Huber, Heinrich, Bullinger, Eric, Rehm, Markus |
| المصدر: | urn:isbn:978-1-60327-380-0 Essentials of Apoptosis, 2nd Edition, 283-297 (2009-07-01) |
| بيانات النشر: | Humana press, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | apoptosis, systems biology, computational modeling, caspases, inhibitor-of-apoptosis proteins, death receptors, mitochondrial outer membrane permeabilization, apoptosome, Life sciences, Sciences du vivant |
| الوصف: | Today, we can avail of comprehensive information on the molecularmechanisms of apoptosis signaling that was gathered during decades of intenseresearch. This chapter presents how mathematical approaches in the field of cellularsignaling are used to integrate this complex and heterogeneous information intocomputational models with the aim to elucidate the functional properties of apopto-tic signaling networks. Mathematical modeling allows one to describe properties ofsignaling systems that emanate from the interplay of the system’s individual compo-nents and has a longstanding and successful history in the fields of physics, chemistry,and their applied engineering sciences. Systems analyses can serve to describe andidentify signaling dynamics,molecular switches, thresholds, and feedback regulatorymechanisms and allow systems properties such as stability and robustness towardexternal perturbations to be identified. Crucially, systems analyses can also serve togenerate novel qualitative and quantitative research hypotheses, which in turn allowfor more focused experimental research approaches. This chapter provides a conciseand critical overview on the current state of systems biology in the field of apoptoticsignaling and the methodology employed. |
| نوع الوثيقة: | book part http://purl.org/coar/resource_type/c_3248Test bookPart |
| اللغة: | English |
| DOI: | 10.1007/978-1-60327-381-7_12 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/19667Test |
| حقوق: | restricted access http://purl.org/coar/access_right/c_16ecTest info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsorb.19667 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1007/978-1-60327-381-7_12 |
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