التفاصيل البيبلوغرافية
| العنوان: |
Protective effects of melatonin on female rat ovary treated with nonylphenol |
| المؤلفون: |
Ozge Goktepe, Esra Balcioglu, Munevver Baran, Ozge Cengiz, Ayse Ceyhan, Pinar Alisan Suna, Demet Bolat, Betul Yalcin, Arzu Yay |
| المصدر: |
Biotechnichistochemistry : official publication of the Biological Stain Commission. 98(1) |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Anti-Mullerian Hormone, Medical Laboratory Technology, Histology, Proto-Oncogene Proteins c-bcl-2, Caspase 3, Ovary, Follicular Atresia, Animals, Female, General Medicine, Rats, Melatonin, bcl-2-Associated X Protein |
| الوصف: |
© 2022 The Biological Stain Commission.We investigated using histochemistry and immunohistochemistry ovarian damage caused by nonylphenol (NP) and the protective effect of melatonin treatment of NP induced ovarian damage. We used 21 female rats divided randomly into three groups: control, NP and melatonin + NP. Histopathological examination of the ovaries, and counting and classification of follicles were performed using Masson’s trichrome staining. Expression of anti-Mullerian hormone (AMH), Bax, Bcl-2 and caspase-3 was detected in the ovaries using immunohistochemistry. Melatonin had an ameliorative effect on NP induced follicular atresia and absence of corpora lutea. More follicles were observed in the ovaries of animals treated with melatonin prior to treatment with NP. AMH immunoreactivity was significantly lower in the NP group than in the melatonin + NP group. NP increased immunostaining for Bax, Bcl-2 and caspase-3. Melatonin significantly reduced the increased expression of Bax, Bcl-2 and caspase-3 due to NP exposure. We found that pretreatment with melatonin is beneficial for protecting the ovaries from damage by NP. |
| تدمد: |
1473-7760 |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba041c98e5f6af1aeb843e4655ebd93Test
https://pubmed.ncbi.nlm.nih.gov/35611760Test |
| حقوق: |
CLOSED |
| رقم الانضمام: |
edsair.doi.dedup.....eba041c98e5f6af1aeb843e4655ebd93 |
| قاعدة البيانات: |
OpenAIRE |
