Corneal nerve structure in patients with primary Sjögren’s syndrome in China
| العنوان: | Corneal nerve structure in patients with primary Sjögren’s syndrome in China |
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| المؤلفون: | Qin Zhang, Huiwen Xu, Yuebo Jin, Fangting Li, Mingwei Zhao, Yaobin Cheng, Jing He, Xin Ying |
| المصدر: | BMC Ophthalmology, Vol 21, Iss 1, Pp 1-7 (2021) BMC Ophthalmology |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, China, Corneal nerve, Sjögren syndrome, Cornea, Ophthalmology, Tear meniscus height, medicine, Humans, In patient, Dry eye disease, Microscopy, Confocal, business.industry, Significant difference, Case-control study, General Medicine, RE1-994, medicine.disease, Control subjects, eye diseases, Sjogren's Syndrome, Case-Control Studies, Tears, Sjögren’s syndrome, Dry Eye Syndromes, In vivo confocal microscopy (IVCM), sense organs, Sjogren s, business, Research Article |
| الوصف: | Background The aim of this study was to evaluate the in vivo confocal microscopic morphology of corneal subbasal nerves and its relationship with clinical parameters in patients with primary Sjögren’s syndrome in China. Methods This was a case control study of 22 dry eye disease (DED) patients with primary Sjögren’s syndrome (pSS) and 20 control subjects with non-Sjögren dry eye disease (NSDE). Each patient underwent an evaluation of ocular surface disease using the tear film break-up time (TBUT), noninvasive tear film break-up time (NIKBUT), noninvasive tear meniscus height (NIKTMH), corneal staining (National Eye Institute scale, NEI), Schirmer I test, meibography, and corneal subbasal nerve analysis with in vivo confocal microscopy (IVCM). The right eye of each subject was included in this study. Results SS patients showed a shorter TBUT (P = 0.009) and Schirmer I test results (P = 0.028) than the NSDE group. However, there was no significant difference in NIKBUT between the two groups (P = 0.393). The nerve density of subbasal nerves, number of nerves and tortuosity of the SS group were significantly lower than those of the NSDE group (P = 0.001, P P = 0.039, respectively). In the SS group, the mean nerve length was correlated with age and the Schirmer I test (r = − 0.519, P = 0.013 and r = 0.463, P = 0.035, respectively). Corneal staining was correlated with nerve density and the number of nerves (r = − 0.534, P = 0.013 and r = − 0.487, P = 0.025, respectively). Conclusions Sjögren syndrome dry eye (SSDE) patients have more severe clinical dry eye parameters than non-Sjögren dry eye disease (NSDE) patients. Compared with NSDE patients, we found that SSDE patients showed decreased corneal subbasal nerve density and numbers. |
| اللغة: | English |
| تدمد: | 1471-2415 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc3e103f62e92f44d956ee062b0d2d9Test https://doaj.org/article/ecbbeca415614fd08858c03506c71415Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3fc3e103f62e92f44d956ee062b0d2d9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712415 |
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