Polymorphic Variants in NR 1I3 and UGT 2B7 Predict Taxane Neurotoxicity and Have Prognostic Relevance in Patients With Breast Cancer: A Case‐Control Study
| العنوان: | Polymorphic Variants in |
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| المؤلفون: | Francesca Scionti, Fernanda Fabiani, Daniele Caracciolo, Grazia Arpino, Pierosandro Tagliaferri, Teresa Galeano, Nicoletta Staropoli, Mario Cannataro, Mariamena Arbitrio, Pierfrancesco Tassone, Emanuela Altomare, Maria Teresa Di Martino, Daniele Santini, Francesco Grillone, Giuseppe Agapito, Eleonora Iuliano |
| المصدر: | Clinical Pharmacology & Therapeutics. 106:422-431 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Pharmacology, Oncology, medicine.medical_specialty, Taxane, Receiver operating characteristic, business.industry, Case-control study, medicine.disease, 030226 pharmacology & pharmacy, UGT2B7, Efficacy, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, 030220 oncology & carcinogenesis, Internal medicine, Toxicity, Medicine, Pharmacology (medical), business, ADME |
| الوصف: | Taxane-related peripheral neuropathy (TrPN) is a dose-limiting toxicity with important interindividual variability. Genetic polymorphisms in absorption, distribution, metabolism, and excretion (ADME) genes may account for variability in drug efficacy and/or toxicity. By the use of Affymetrix drug-metabolizing enzyme and transporter microarray platform, in a retrospective case-control study, the correlation between ADME polymorphic variants and grades ≥ 2-3-TrPN was investigated. In a breast cancer (BC) training set, five single-nucleotide polymorphisms in NR1I3 and UDP-glucuronosyltransferase (UGT)2B7 genes were correlated to grades ≥ 2-3-TrPN protection. By receiver operating characteristic curves, the grades ≥ 2-3-TrPN-related candidate biomarkers in an independent series of 54 patients with BC (17 cases and 37 controls) were validated. NR1I3 was correlated to paclitaxel-TrPN and UGT2B7 to docetaxel-TrPN. Moreover, a genetic signature of prognostic relevance for BC outcome was found. Our findings might have potential relevance for personalized management of patients with BC for prevention of treatment failure in ultrametabolizer genetic variants. |
| تدمد: | 1532-6535 0009-9236 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::bc39ba6ef2c921fd1cc05027a393f48dTest https://doi.org/10.1002/cpt.1391Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........bc39ba6ef2c921fd1cc05027a393f48d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15326535 00099236 |
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