التفاصيل البيبلوغرافية
| العنوان: |
Effectiveness of the 2010–2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case–case comparison, case-control study |
| المؤلفون: |
Puig-Barberà, J.1,2 jpuigb55@gmail.com, Díez-Domingo, J.1, Arnedo-Pena, A.2, Ruiz-García, M.2, Pérez-Vilar, S.1, Micó-Esparza, J.L.3, Belenguer-Varea, A.4, Carratalá-Munuera, C.5, Gil-Guillén, V.5, Schwarz-Chavarri, H.6 |
| المصدر: |
Vaccine. Aug2012, Vol. 30 Issue 39, p5714-5720. 7p. |
| مصطلحات موضوعية: |
*SEASONAL influenza, *INFLUENZA vaccines, *HOSPITAL care, *DRUG efficacy, *REVERSE transcriptase polymerase chain reaction, *MEDICAL statistics, *CASE-control method, *COMPARATIVE studies |
| مستخلص: |
Abstract: Introduction: We estimated influenza vaccine effectiveness (IVE) to prevent laboratory-confirmed influenza-related hospitalizations in patients 18 years old or older during the 2010–2011 influenza season. Methods: We conducted a prospective case-control study in five hospitals, in Valencia, Spain. Study subjects were consecutive emergency hospitalizations for predefined conditions associated with an influenza-like illness episode <8 days before admission. Patients were considered immunized if vaccinated ≥14 days before influenza-like illness onset. Cases were those with a real time reverse transcriptase polymerase chain reaction (RT-PCR) positive for influenza and controls were RT-PCR positive for other respiratory viruses. Adjusted IVE was estimated as 100×(1−adjusted odds ratio). To account for indication bias we computed adjusted IVE for respiratory syncytial virus related hospitalizations. Results: Of 826 eligible hospitalized patients, 102 (12%) were influenza positive and considered cases, and 116 (14%) were positive for other respiratory viruses and considered controls. Adjusted IVE was 54% (95% confidence interval, 11–76%). By subgroup, adjusted IVE was 53% (4–77%) for those with high-risk conditions, 59% (16–79%) for those ≥60 years of age, and, 54% (4–79%) for those ≥60 years of age with high-risk conditions. No influenza vaccine effect was observed against respiratory syncytial virus related hospitalization. Conclusion: Influenza vaccination was associated with a significant reduction on the risk of confirmed influenza hospitalization, irrespective of age and high-risk conditions. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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