التفاصيل البيبلوغرافية
| العنوان: |
The killer immunoglobulin-like receptor KIR3DL1 in combination with HLA-Bw4 is protective against multiple sclerosis in African Americans |
| المؤلفون: |
Hollenbach, JA, Pando, MJ, Caillier, SJ, Gourraud, P-A, Oksenberg, JR |
| المصدر: |
Genes & Immunity, vol 17, iss 3 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2016 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Immunology, Multiple Sclerosis, Brain Disorders, Neurosciences, Neurodegenerative, Autoimmune Disease, Genetics, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Black or African American, Alleles, Case-Control Studies, HLA-B Antigens, Humans, Linkage Disequilibrium, Receptors, KIR3DL1 |
| جغرافية الموضوع: |
199 - 202 |
| الوصف: |
We investigated the role of the KIR loci and their HLA class I ligands in a large cohort of African American multiple sclerosis (MS) patients (N=907) and controls (N=1456). No significant differences in carrier frequencies for any KIR locus or haplotype were observed between cases and controls. However, examination of KIR in the context of their cognate HLA ligands revealed a strong protective effect for KIR3DL1 in combination with HLA-A and -B alleles bearing the Bw4 motif (P=10(-8); odds ratio (OR)=0.60, confidence interval (CI)=0.50-0.71) and the Bw4 ligand alone (P<10(-6); OR=0.63, CI=0.53-0.75). The observed effect cannot be explained by either a specific HLA-B allele or by linkage disequilibrium with HLA-DRB1 or HLA-A. The protective effect was observed only in individuals who were not positive for the MS risk allele HLA-DRB1*15:01 (P<10(-6); OR=0.61, CI=0.51-0.74). Our study, the first investigation of KIR and MS in African Americans, confirms and refines previous findings in a European cohort. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt6cw6k4w1; https://escholarship.org/uc/item/6cw6k4w1Test |
| الإتاحة: |
https://escholarship.org/uc/item/6cw6k4w1Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.1DA9C87B |
| قاعدة البيانات: |
BASE |
