التفاصيل البيبلوغرافية
| العنوان: |
Remote testing of vitamin D levels across the UK MS population—A case control study. |
| المؤلفون: |
Vickaryous, Nicola, Jitlal, Mark, Jacobs, Benjamin Meir, Middleton, Rod, Chandran, Siddharthan, MacDougall, Niall John James, Giovannoni, Gavin, Dobson, Ruth |
| المصدر: |
PLoS ONE; 12/30/2020, Vol. 15 Issue 12, p1-13, 13p |
| مصطلحات موضوعية: |
VITAMIN D, VITAMIN D deficiency, DIETARY supplements, CASE studies |
| مصطلحات جغرافية: |
UNITED Kingdom |
| مستخلص: |
Objective: The association between vitamin D deficiency and multiple sclerosis (MS) is well described. We set out to use remote sampling to ascertain vitamin D status and vitamin D supplementation in a cross-sectional study of people with MS across the UK. Methods: People with MS and matched controls were recruited from across the UK. 1768 people with MS enrolled in the study; remote sampling kits were distributed to a subgroup. Dried blood spots (DBS) were used to assess serum 25(OH)D in people with MS and controls. Results: 1768 MS participants completed the questionnaire; 388 MS participants and 309 controls provided biological samples. Serum 25(OH)D was higher in MS than controls (median 71nmol/L vs 49nmol/L). A higher proportion of MS participants than controls supplemented (72% vs 26%, p<0.001); people with MS supplemented at higher vD doses than controls (median 1600 vs 600 IU/day, p<0.001). People with MS who did not supplement had lower serum 25(OH)D levels than non-supplementing controls (median 38 nmol/L vs 44 nmol/L). Participants engaged well with remote sampling. Conclusions: The UK MS population have higher serum 25(OH)D than controls, mainly as a result of vitamin D supplementation. Remote sampling is a feasible way of carrying out large studies. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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