A Case Report of Metastatic Castration-Resistant Prostate Cancer Harboring a PTEN Loss
| العنوان: | A Case Report of Metastatic Castration-Resistant Prostate Cancer Harboring a PTEN Loss |
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| المؤلفون: | Zin W. Myint, Derek B. Allison, Carleton S. Ellis |
| المصدر: | Frontiers in Oncology Frontiers in Oncology, Vol 11 (2021) |
| بيانات النشر: | Frontiers Media SA, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, Combination therapy, medicine.medical_treatment, Population, Case Report, chemistry.chemical_compound, Prostate cancer, Internal medicine, medicine, PTEN, education, RC254-282, PI3K/AKT/mTOR pathway, education.field_of_study, biology, business.industry, Abiraterone acetate, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Carboplatin, PI3K/AKT pathway, Radiation therapy, abiraterone acetate, ATM/Chk2/p53 signal pathway, chemistry, metastatic castration refractory prostate cancer, carboplatin, biology.protein, business |
| الوصف: | The treatment landscape of metastatic castration-resistant prostate cancer (mCRPC) has dramatically improved over the last decade; however, patients with visceral metastases are still faced with poor outcomes. Phosphatase and tensin homolog (PTEN) loss is observed in 40%–60% of mCRPC patients and is also associated with a poor prognosis. Several PI3K/AKT/mTOR pathway inhibitors have been studied, with disappointing anti-tumor activity. Here, we present a case of a patient with heavily treated mCRPC who had a modest tumor response to concurrent carboplatin, abiraterone acetate/prednisone, and liver-directed radiation therapy. We discuss the potential rationale supporting the use of this combination therapy and its safety in mCRPC. While the underlying basic mechanism of our patient’s anti-tumor response remains uncertain, we suggest that further prospective studies are warranted to evaluate whether this combination therapy is effective in this population of patients with pre-treated mCRPC and PTEN loss. |
| تدمد: | 2234-943X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343518d5e82128cbd26c49e73039e817Test https://doi.org/10.3389/fonc.2021.731002Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....343518d5e82128cbd26c49e73039e817 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2234943X |
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