المؤلفون: Zhang, Cheng, Konermann, Silvana, Brideau, Nicholas J, Lotfy, Peter, Wu, Xuebing, Novick, Scott J, Strutzenberg, Timothy, Griffin, Patrick R, Hsu, Patrick D, Lyumkis, Dmitry

المصدر: Cell. 175(1)

مصطلحات موضوعية: Genetics, Bioengineering, Biotechnology, Underpinning research, 1.1 Normal biological development and functioning, Quality Education, CRISPR-Cas Systems, Clustered Regularly Interspaced Short Palindromic Repeats, Cryoelectron Microscopy, Endonucleases, HEK293 Cells, Humans, Molecular Conformation, RNA, RNA, Guide, Kinetoplastida, Ribonucleases, CRISPR, Cas13, Cas13d, Cas9, RNA interference, RNA targeting, cryo-EM, shRNA, structure, type VI, Biological Sciences, Medical and Health Sciences, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/2n23w39jTest

المؤلفون: Shmakov, Sergey^1,2, Abudayyeh, Omar O.^3,4,5,6, Makarova, Kira S.², Wolf, Yuri I.², Gootenberg, Jonathan S.^3,4,5,6, Semenova, Ekaterina⁷, Minakhin, Leonid⁷, Joung, Julia^3,4,5,6, Konermann, Silvana^3,4,5,6, Severinov, Konstantin^1,7,8, Zhang, Feng^3,4,5,6 zhang@broadinstitute.org, Koonin, Eugene V.² koonin@ncbi.nlm.nih.gov

المصدر: Molecular Cell. Nov2015, Vol. 60 Issue 3, p385-397. 13p.

مصطلحات موضوعية: *CRISPRS, *RIBONUCLEASES, *ENDONUCLEASES, *COMPARATIVE studies, *GENETIC recombination

المؤلفون: Osamu Nureki, Yinqing Li, Feng Zhang, Ryuichiro Ishitani, Takanori Nakane, Kira S. Makarova, Ian Slaymaker, Hisato Hirano, Hiroshi Nishimasu, Bernd Zetsche, Iana Fedorova, Eugene V. Koonin, Takashi Yamano

المساهمون: Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Biology, Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research at MIT, Ran, Fei, Hsu, Patrick, Konermann, Silvana M, Shehata, Soraya I., Zhang, Feng

المصدر: PMC
Cell, vol 156, iss 5

مصطلحات موضوعية: Models, Molecular, CRISPR/Cpf1, CRISPR-Associated Proteins, Crystallography, X-Ray, Medical and Health Sciences, chemistry.chemical_compound, Endonuclease, 0302 clinical medicine, Models, Guide RNA, Kinetoplastida, Genetics, 0303 health sciences, Crystallography, biology, Bacterial, Biological Sciences, 3. Good health, RNA, Bacterial, Protospacer adjacent motif, Infectious Diseases, RNA, Guide, Kinetoplastida, Heteroduplex, DNA, Bacterial, Protein Structure, Streptococcus pyogenes, 1.1 Normal biological development and functioning, Molecular Sequence Data, Computational biology, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Underpinning research, Amino Acid Sequence, 030304 developmental biology, Nuclease, Bacteria, Biochemistry, Genetics and Molecular Biology(all), Cas9, Human Genome, Molecular, DNA, Endonucleases, Protein Structure, Tertiary, Emerging Infectious Diseases, chemistry, X-Ray, biology.protein, RNA, Sequence Alignment, Tertiary, Guide, 030217 neurology & neurosurgery, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c372b4a9e4131272a04a18f8e6e6bdc3Test
https://doi.org/10.1016/j.cell.2014.02.001Test

المؤلفون: Feng Zhang, Silvana Konermann, James E. Dahlman, Omar O. Abudayyeh, Jonathan S. Gootenberg, Julia Joung

المساهمون: Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research at MIT, Abudayyeh, Omar Osama, Joung, Julia, Gootenberg, Jonathan S., Zhang, Feng, Konermann, Silvana

المصدر: PMC
Nature biotechnology

مصطلحات موضوعية: Biomedical Engineering, Bioengineering, Applied Microbiology and Biotechnology, Article, 03 medical and health sciences, Gene Knockout Techniques, 0302 clinical medicine, Bacterial Proteins, CRISPR-Associated Protein 9, Gene expression, CRISPR, Humans, Gene, Gene knockout, 030304 developmental biology, 0303 health sciences, Nuclease, biology, Cas9, HEK 293 cells, Endonucleases, Molecular biology, 3. Good health, HEK293 Cells, biology.protein, Molecular Medicine, 030217 neurology & neurosurgery, Biotechnology, RNA, Guide, Kinetoplastida

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca80b9c6e2ed270412348b27cfa0bf7Test
https://orcid.org/0000-0001-6656-5002Test

المؤلفون: Feng Zhang, Yuri I. Wolf, Konstantin Severinov, Silvana Konermann, Jonathan S. Gootenberg, Eugene V. Koonin, Ekaterina Semenova, Leonid Minakhin, Julia Joung, Sergey Shmakov, Omar O. Abudayyeh, Kira S. Makarova

المساهمون: Massachusetts Institute of Technology. Department of Biological Engineering, McGovern Institute for Brain Research at MIT, Abudayyeh, Omar Osama, Gootenberg, Jonathan S, Joung, Julia, Konermann, Silvana M, Zhang, Feng

المصدر: PMC

مصطلحات موضوعية: Trans-activating crRNA, Genetics, Recombination, Genetic, Nuclease, biology, Bacteria, Cas9, RNase P, Effector, RNA, Cell Biology, Article, Protein Structure, Tertiary, Evolution, Molecular, chemistry.chemical_compound, RNA, Bacterial, Ribonucleases, chemistry, Bacterial Proteins, biology.protein, CRISPR, CRISPR-Cas Systems, Molecular Biology, DNA

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4fe9187285bd1697afaafad3c35abdTest
https://pubmed.ncbi.nlm.nih.gov/26593719Test

المؤلفون: Alexandro E. Trevino, Anthony C. Chiu, Patrick D. Hsu, David A. Scott, Sidi Chen, Albert W. Cheng, Andrea J. Kriz, Phillip A. Sharp, Silvana Konermann, Feng Zhang, Daniel B. Dadon, Rudolf Jaenisch, Xuebing Wu

المساهمون: Massachusetts Institute of Technology. Department of Biology, McGovern Institute for Brain Research at MIT, Whitehead Institute for Biomedical Research, Koch Institute for Integrative Cancer Research at MIT, Wu, Xuebing, Chiu, Anthony Chun-yin, Chen, Sidi, Sharp, Phillip A., Scott, David Arthur, Hsu, Patrick, Trevino, Alexandro E., Konermann, Silvana M., Zhang, Feng, Kriz, Andrea J., Dadon, Daniel Benjamin, Jaenisch, Rudolf

المصدر: Nature biotechnology, vol 32, iss 7
PMC

مصطلحات موضوعية: Cells, Molecular Sequence Data, Biomedical Engineering, Bioengineering, Biology, Applied Microbiology and Biotechnology, Article, Mice, Genetic, Models, CRISPR, Animals, Deoxyribonuclease I, Guide RNA, Binding site, Gene, Cells, Cultured, Embryonic Stem Cells, Genetics, Cultured, Binding Sites, Genome, Base Sequence, Models, Genetic, Cas9, Chromatin, DNA-Binding Proteins, Protospacer adjacent motif, Molecular Medicine, CRISPR-Cas Systems, Biotechnology, Protein Binding

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93a41c1c755061d128c6bddf0d92a93Test
https://europepmc.org/articles/PMC4145672Test/

المساهمون: Shmakov, Sergey, Abudayyeh, Omar O., Makarova, Kira S., Wolf, Yuri I, Gootenberg, Jonathan S., Semenova, Ekaterina, Minakhin, Leonid, Joung, Julia, Konermann, Silvana, Severinov, Konstantin, Zhang, Feng, Koonin, Eugene V.

المصدر: Mol Cell. 60(3):385-397.

مصطلحات موضوعية: Article, CRISPR-Cas adaptive immunity, Cas9, Cpf1, crRNA, tracrRNA, PAM, RuvC-like endonuclease, HEPN domain, computational discovery pipeline, RNA-seq, Bacteria, Bacterial Proteins, CRISPR-Cas Systems, Evolution, Molecular, Protein Structure, Tertiary, RNA, Bacterial, Recombination, Genetic, Ribonucleases

العلاقة: cdc:37888; http://stacks.cdc.gov/view/cdc/37888Test/

الإتاحة: http://stacks.cdc.gov/view/cdc/37888Test/

المساهمون: Shmakov, Sergey, Abudayyeh, Omar O., Makarova, Kira S., Wolf, Yuri I, Gootenberg, Jonathan S., Semenova, Ekaterina, Minakhin, Leonid, Joung, Julia, Konermann, Silvana, Severinov, Konstantin, Zhang, Feng, Koonin, Eugene V.

المصدر: Mol Cell. 60(3):385-397.

مصطلحات موضوعية: Article, CRISPR-Cas adaptive immunity, Cas9, Cpf1, crRNA, tracrRNA, PAM, RuvC-like endonuclease, HEPN domain, computational discovery pipeline, RNA-seq, Bacteria, Bacterial Proteins, CRISPR-Cas Systems, Evolution, Molecular, Protein Structure, Tertiary, RNA, Bacterial, Recombination, Genetic, Ribonucleases, geo, stat

العلاقة: http://stacks.cdc.gov/view/cdc/37888Test/

الإتاحة: http://stacks.cdc.gov/view/cdc/37888Test/