Automated Entire Thrombus Density Measurements for Robust and Comprehensive Thrombus Characterization in Patients with Acute Ischemic Stroke
| العنوان: | Automated Entire Thrombus Density Measurements for Robust and Comprehensive Thrombus Characterization in Patients with Acute Ischemic Stroke |
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| المؤلفون: | Santos, Emilie M. M., Niessen, Wiro J., Yoo, Albert J., Berkhemer, Olvert A., Beenen, Ludo F., Majoie, Charles B., Marquering, Henk A., Fransen, Puck S. S., Beumer, Debbie, van den Berg, Lucie A., Lingsma, Hester F., Schonewille, Wouter J., Vos, Jan Albert, Nederkoorn, Paul J., Wermer, Marieke J. H., van Walderveen, Marianne A. A., Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, L. Jaap, Lo, Rob H., van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L. M., van den Berg, Jan S. P., van Hasselt, Boudewijn A. A. M., Aerden, Leo A. M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C. J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H. C. M. L., Heijboer, Roel J. J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Sprengers, Marieke E. S., van den Berg, René, Roos, Yvo B. W. E. M. |
| المساهمون: | Other departments, Radiology and Nuclear Medicine, ACS - Amsterdam Cardiovascular Sciences, ANS - Neurovascular Disorders, Graduate School, Other Research, Biomedical Engineering and Physics, Neurology, Public and occupational health, EMGO - Quality of care, Radiology and nuclear medicine, Amsterdam Neuroscience - Neurovascular Disorders, Medical Informatics, Radiology & Nuclear Medicine, MUMC+: MA Neurologie (3), Klinische Neurowetenschappen, RS: CARIM - R3.03 - Cerebral small vessel disease, Beeldvorming, MUMC+: DA BV Medisch Specialisten Radiologie (9), RS: CARIM - R3.11 - Imaging |
| المصدر: | PLoS ONE, 11(1). Public Library of Science PLoS ONE, 11(1):e0145641. Public Library of Science PLoS One, 11 MR CLEAN Investigators 2016, ' Automated entire thrombus density measurements for robust and comprehensive thrombus characterization in patients with acute ischemic stroke ', PLoS ONE, vol. 11, no. 1, e0145641 . https://doi.org/10.1371/journal.pone.0145641Test PLoS ONE, Vol 11, Iss 1, p e0145641 (2016) PLoS ONE PLoS One (print), 11(1). Public Library of Science PLOS ONE, 11(1):e0145641. Public Library of Science PLoS One, 11, 1 PLoS ONE, 11(1):e0145641. PUBLIC LIBRARY SCIENCE |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, lcsh:Medicine, Research Support, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Absorptiometry, Photon, 0302 clinical medicine, Interquartile range, Linear regression, medicine, Journal Article, Humans, cardiovascular diseases, Thrombus, Absorptiometry, lcsh:Science, Non-U.S. Gov't, Stroke, Acute ischemic stroke, Tomography, Aged, Multidisciplinary, business.industry, Research Support, Non-U.S. Gov't, lcsh:R, Thrombosis, Cerebral Arteries, Middle Aged, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], medicine.disease, Photon, Internal, X-Ray Computed, Kurtosis, cardiovascular system, lcsh:Q, Female, Radiology, Carotid Artery, Tomography, X-Ray Computed, business, Carotid Artery, Internal, 030217 neurology & neurosurgery, Research Article, circulatory and respiratory physiology |
| الوصف: | Contains fulltext : 168317.PDF (Publisher’s version ) (Open Access) BACKGROUND AND PURPOSE: In acute ischemic stroke (AIS) management, CT-based thrombus density has been associated with treatment success. However, currently used thrombus measurements are prone to inter-observer variability and oversimplify the heterogeneous thrombus composition. Our aim was first to introduce an automated method to assess the entire thrombus density and then to compare the measured entire thrombus density with respect to current standard manual measurements. MATERIALS AND METHOD: In 135 AIS patients, the density distribution of the entire thrombus was determined. Density distributions were described using medians, interquartile ranges (IQR), kurtosis, and skewedness. Differences between the median of entire thrombus measurements and commonly applied manual measurements using 3 regions of interest were determined using linear regression. RESULTS: Density distributions varied considerably with medians ranging from 20.0 to 62.8 HU and IQRs ranging from 9.3 to 55.8 HU. The average median of the thrombus density distributions (43.5 +/- 10.2 HU) was lower than the manual assessment (49.6 +/- 8.0 HU) (p |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be38c21d9bdcbd8fd9a5611a27d3ea93Test https://pure.amc.nl/en/publications/automated-entire-thrombus-density-measurements-for-robust-and-comprehensive-thrombus-characterization-in-patients-with-acute-ischemic-strokeTest(8a0b0565-4d91-455c-ad19-7a27d7182982).html |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....be38c21d9bdcbd8fd9a5611a27d3ea93 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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