Aortic Wall Inflammation Predicts Abdominal Aortic Aneurysm Expansion, Rupture, and Need for Surgical Repair
| العنوان: | Aortic Wall Inflammation Predicts Abdominal Aortic Aneurysm Expansion, Rupture, and Need for Surgical Repair |
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| المؤلفون: | Newby, David, Forsythe, Rachael, McBride, Olivia, Robson, Jennifer, Vesey, Alex, Chalmers, Roderick, Burns, Paul, Garden, O James, Semple, Scott, Dweck, Marc, Gray, Calum, MacGillivray, Tom, Wang, Chengjia, Koutraki, Yolanda Georgia, Mitchard, Neil, Cooper, Annette, van Beek, Edwin, McKillop, Graham, Ho, Weiyang, Fraser, Liz, Cuthbert, Hayley, Hoskins, Peter, Doyle, Barry, Conlisk, Noel, Stuart, Wesley, Berry, Colin, Roditi, Giles, Murdoch, Laura, Holdsworth, Richard, Scott, Emma, Milne, Lyndsey, Strachan, Fiona, Wee, Fiona, Oatey, Katerine, Graham, Catriona, Murray, Gordon, Milne, Garry, Bucukoglu, Marise, Goodman, Kirsteen, Kaczynski, Jakub, Shah, Anoop S V, Tambyraja, Andrew, Brittenden, Julie, Lambie, Robert, Norrie, John |
| المصدر: | Circulation Newby, D, Forsythe, R, McBride, O, Robson, J, Vesey, A, Chalmers, R, Burns, P, Garden, O J, Semple, S, Dweck, M, Gray, C, MacGillivray, T, Wang, C, Koutraki, Y G, Mitchard, N, Cooper, A, van Beek, E, McKillop, G, Ho, W, Fraser, L, Cuthbert, H, Hoskins, P, Doyle, B, Conlisk, N, Stuart, W, Berry, C, Roditi, G, Murdoch, L, Holdsworth, R, Scott, E, Milne, L, Strachan, F, Wee, F, Oatey, K, Graham, C, Murray, G, Milne, G, Bucukoglu, M, Goodman, K, Kaczynski, J, Shah, A S V, Tambyraja, A, Brittenden, J & Lambie, R & Norrie, J 2017, ' Aortic Wall Inflammation Predicts Abdominal Aortic Aneurysm Expansion, Rupture, and Need for Surgical Repair. ', Circulation, vol. 136, no. 9, pp. 787–797 . https://doi.org/10.1161/CIRCULATIONAHA.117.028433Test |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Contrast Media, Blood Pressure, 030204 cardiovascular system & hematology, 0302 clinical medicine, Original Research Articles, Medicine, Prospective Studies, 030212 general & internal medicine, Magnetite Nanoparticles, Aorta, medicine.diagnostic_test, Smoking, Dextrans, Middle Aged, Magnetic Resonance Imaging, Abdominal aortic aneurysm, 3. Good health, Survival Rate, cardiovascular system, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Female, Radiology, medicine.symptom, Cardiology and Cardiovascular Medicine, MRI, medicine.medical_specialty, Aortic Rupture, Inflammation, Disease-Free Survival, 03 medical and health sciences, Sex Factors, abdominal aortic aneurysm, Physiology (medical), medicine.artery, Journal Article, Humans, In patient, Aortic rupture, Aged, Proportional Hazards Models, Surgical repair, business.industry, Magnetic resonance imaging, medicine.disease, Aortic wall, repair, rupture, business, Aortic Aneurysm, Abdominal |
| الوصف: | Supplemental Digital Content is available in the text. Background: Ultrasmall superparamagnetic particles of iron oxide (USPIO) detect cellular inflammation on magnetic resonance imaging (MRI). In patients with abdominal aortic aneurysm, we assessed whether USPIO-enhanced MRI can predict aneurysm growth rates and clinical outcomes. Methods In a prospective multicenter open-label cohort study, 342 patients with abdominal aortic aneurysm (diameter ≥40 mm) were classified by the presence of USPIO enhancement and were monitored with serial ultrasound and clinical follow-up for ≥2 years. The primary end point was the composite of aneurysm rupture or repair. Results Participants (85% male, 73.1±7.2 years) had a baseline aneurysm diameter of 49.6±7.7 mm, and USPIO enhancement was identified in 146 (42.7%) participants, absent in 191 (55.8%), and indeterminant in 5 (1.5%). During follow-up (1005±280 days), 17 (5.0%) abdominal aortic aneurysm ruptures, 126 (36.8%) abdominal aortic aneurysm repairs, and 48 (14.0%) deaths occurred. Compared with those without uptake, patients with USPIO enhancement have increased rates of aneurysm expansion (3.1±2.5 versus 2.5±2.4 mm/year, P=0.0424), although this was not independent of current smoking habit (P=0.1993). Patients with USPIO enhancement had higher rates of aneurysm rupture or repair (47.3% versus 35.6%; 95% confidence intervals, 1.1–22.2; P=0.0308). This finding was similar for each component of rupture (6.8% versus 3.7%, P=0.1857) or repair (41.8% versus 32.5%, P=0.0782). USPIO enhancement was associated with reduced event-free survival for aneurysm rupture or repair (P=0.0275), all-cause mortality (P=0.0635), and aneurysm-related mortality (P=0.0590). Baseline abdominal aortic aneurysm diameter (P |
| وصف الملف: | application/pdf |
| تدمد: | 1524-4539 0009-7322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db6ad1b9382ec9d85798d92d95c3870Test https://doi.org/10.1161/circulationaha.117.028433Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7db6ad1b9382ec9d85798d92d95c3870 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244539 00097322 |
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