دورية أكاديمية
Atherosclerotic Risk Factors and Their Association With Hospital Mortality Among Patients With First Myocardial Infarction (from the National Registry of Myocardial Infarction)
| العنوان: | Atherosclerotic Risk Factors and Their Association With Hospital Mortality Among Patients With First Myocardial Infarction (from the National Registry of Myocardial Infarction) |
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| المؤلفون: | Canto, John G., Kiefe, Catarina I., Rogers, William J., Peterson, Eric D., Frederick, Paul D., French, William J., Gibson, C. Michael, Pollack, Charles V. Jr., Ornato, Joseph P., Zalenski, Robert J., Penney, Jan, Tiefenbrunn, Alan J., Greenland, Philip, NRMI Investigators |
| المساهمون: | Department of Quantitative Health Sciences |
| المصدر: | The American journal of cardiology ; 110 ; 9 ; 1256-61 |
| سنة النشر: | 2022 |
| المجموعة: | University of Massachusetts, Medical School: eScholarship@UMMS |
| مصطلحات موضوعية: | Myocardial Infarction, Atherosclerosis, Risk Factors, Hospital Mortality, UMCCTS funding, Cardiology, Cardiovascular Diseases, Epidemiology, Health Services Research |
| الوصف: | Few studies have examined associations between atherosclerotic risk factors and short-term mortality after first myocardial infarction (MI). Histories of 5 traditional atherosclerotic risk factors at presentation (diabetes, hypertension, smoking, dyslipidemia, and family history of premature heart disease) and hospital mortality were examined among 542,008 patients with first MIs in the National Registry of Myocardial Infarction (1994 to 2006). On initial MI presentation, history of hypertension (52.3%) was most common, followed by smoking (31.3%). The least common risk factor was diabetes (22.4%). Crude mortality was highest in patients with MI with diabetes (11.9%) and hypertension (9.8%) and lowest in those with smoking histories (5.4%) and dyslipidemia (4.6%). The inclusion of 5 atherosclerotic risk factors in a stepwise multivariate model contributed little toward predicting hospital mortality over age alone (C-statistic = 0.73 and 0.71, respectively). After extensive multivariate adjustments for clinical and sociodemographic factors, patients with MI with diabetes had higher odds of dying (odds ratio [OR] 1.23, 95% confidence interval [CI] 1.20 to 1.26) than those without diabetes and similarly for hypertension (OR 1.08, 95% CI 1.06 to 1.11). Conversely, family history (OR 0.71, 95% CI 0.69 to 0.73), dyslipidemia (OR 0.62, 95% CI 0.60 to 0.64), and smoking (OR 0.85, 95% CI 0.83 to 0.88) were associated with decreased mortality (C-statistic = 0.82 for the full model). In conclusion, in the setting of acute MI, histories of diabetes and hypertension are associated with higher hospital mortality, but the inclusion of atherosclerotic risk factors in models of hospital mortality does not improve predictive ability beyond other major clinical and sociodemographic characteristics. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 22840346 |
| العلاقة: | Link to Article in PubMed; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494670Test/; Am J Cardiol. 2012 Nov 1;110(9):1256-61. doi:10.1016/j.amjcard.2012.06.025. Link to article on publisher's site; 0002-9149 (Linking); http://hdl.handle.net/20.500.14038/46545Test; https://escholarship.umassmed.edu/qhs_pp/1011Test; 3393443; qhs_pp/1011 |
| DOI: | 10.1016/j.amjcard.2012.06.025 |
| الإتاحة: | https://doi.org/10.1016/j.amjcard.2012.06.025Test https://doi.org/20.500.14038/46545Test https://hdl.handle.net/20.500.14038/46545Test https://escholarship.umassmed.edu/qhs_pp/1011Test |
| رقم الانضمام: | edsbas.54E3CC03 |
| قاعدة البيانات: | BASE |
| تدمد: | 22840346 |
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| DOI: | 10.1016/j.amjcard.2012.06.025 |