دورية أكاديمية
Cardiac Autonomic Neuropathy in Diabetes: A Predictor of Cardiometabolic Events
| العنوان: | Cardiac Autonomic Neuropathy in Diabetes: A Predictor of Cardiometabolic Events |
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| المؤلفون: | Vinik, Aaron I., Casellini, Carolina, Parson, Henri K., Colberg, Sheri R., Nevoret, Marie-laure |
| المصدر: | Human Movement Sciences Faculty Publications |
| بيانات النشر: | ODU Digital Commons |
| سنة النشر: | 2018 |
| المجموعة: | Old Dominion University: ODU Digital Commons |
| مصطلحات موضوعية: | Cardiac autonomic neuropathy, Sympathetic, Parasympathetic, Dopamine deficiency, Insulin resistance, Cardiovascular event prediction, Heart rate variability, Diabetes, Cardiovascular Diseases, Endocrinology, and Metabolism, Neurology, Neurosciences |
| الوصف: | Autonomic nervous system (ANS) imbalance manifesting as cardiac autonomic neuropathy in the diabetic population is an important predictor of cardiovascular events. Symptoms and signs of ANS dysfunction, such as resting heart rate elevations, diminished blood pressure responses to standing, and altered time and frequency domain measures of heart rate variability in response to deep breathing, standing, and the Valsalva maneuver, should be elicited from all patients with diabetes and prediabetes. With the recognition of the presence of ANS imbalance or for its prevention, a rigorous regime should be implemented with lifestyle modification, physical activity, and cautious use of medications that lower blood glucose. Rather than intensifying diabetes control, a regimen tailored to the individual risk of autonomic imbalance should be implemented. New agents that may improve autonomic function, such as SGLT2 inhibitors, should be considered and the use of incretins monitored. One of the central mechanisms of dysfunction is disturbance of the hypothalamic cardiac clock, a consequence of dopamine deficiency that leads to sympathetic dominance, insulin resistance, and features of the metabolic syndrome. An improvement in ANS balance may be critical to reducing cardiovascular events, cardiac failure, and early mortality in the diabetic population. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://digitalcommons.odu.edu/hms_fac_pubs/76Test; https://digitalcommons.odu.edu/context/hms_fac_pubs/article/1076/viewcontent/Cardiac_2018_Colberg.pdfTest |
| DOI: | 10.3389/fnins.2018.00591 |
| الإتاحة: | https://doi.org/10.3389/fnins.2018.00591Test https://digitalcommons.odu.edu/hms_fac_pubs/76Test https://digitalcommons.odu.edu/context/hms_fac_pubs/article/1076/viewcontent/Cardiac_2018_Colberg.pdfTest |
| رقم الانضمام: | edsbas.34036187 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fnins.2018.00591 |
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