التفاصيل البيبلوغرافية
| العنوان: |
Gender‐affirming hormone therapy decreases d‐dimer but worsens insulin sensitivity in transgender women. |
| المؤلفون: |
Lake, Jordan E., Miao, Hongyu, Bowman, Emily R., Clark, Jesse L., Hyatt, Ana N., Kettelhut, Aaren, Lama, Javier R., Reisner, Sari L., Mayer, Kenneth H., Perez‐Brumer, Amaya, Funderburg, Nicholas |
| المصدر: |
HIV Medicine; Nov2023, Vol. 24 Issue 11, p1144-1149, 6p |
| مصطلحات موضوعية: |
CARDIOVASCULAR diseases risk factors, TRANS women, RESEARCH funding, HIGH density lipoproteins, LONGITUDINAL method, HIV, INSULIN resistance |
| مستخلص: |
Objectives: Gender‐affirming hormonal therapies (GAHT) and HIV increase cardiovascular risk for transgender women (TW), yet there is a paucity of data quantifying cardiometabolic changes following GAHT initiation, particularly among TW with HIV. Methods: The Féminas study enrolled TW from October 2016 to March 2017 in Lima, Peru. Participants reported sexual activity that was high risk for HIV acquisition or transmission. All were tested for HIV/ sexually transmitted infection and were given access to GAHT (oestradiol valerate and spironolactone), HIV pre‐exposure prophylaxis (PrEP) or antiretroviral therapy (ART) for 12 months. Biomarker measurement was done on stored serum, whereas fasting glucose and lipids were measured in real time. Results: In all, 170 TW (32 with HIV, 138 without HIV) had median age 27 years and 70% prior GAHT use. At baseline, PCSK9, sCD14, sCD163, IL‐6, sTNFRI/II, CRP and EN‐RAGE levels were significantly higher in TW with HIV than in TW without HIV. High‐density lipoprotein and total cholesterol were lower and insulin and glucose parameters were similar. All TW with HIV started ART, but only five achieved virological suppression at any time. No TW without HIV initiated PrEP. Over 6 months, all participants initiated GAHT and had worsening insulin, glucose and HOMA‐IR. Large d‐dimer decreases also occurred. Similar changes occurred in TW with and without HIV. Conclusions: In this unique cohort of TW, GAHT decreased d‐dimer but worsened insulin sensitivity. Because PrEP uptake and ART adherence were very low, observed effects are primarily attributed to GAHT use. Further study is needed to better understand cardiometabolic changes in TW by HIV serostatus. [ABSTRACT FROM AUTHOR] |
|
Copyright of HIV Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
