دورية أكاديمية
G protein-coupled receptor kinase 2 (GRK2) as a potential therapeutic target in cardiovascular and metabolic diseases
| العنوان: | G protein-coupled receptor kinase 2 (GRK2) as a potential therapeutic target in cardiovascular and metabolic diseases |
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| المؤلفون: | Murga, Cristina, Arcones, Alba C., Cruces-Sande, Marta, Briones, Ana M., Salaices, Mercedes, Mayor Méndez, Federico Jr. |
| المساهمون: | Ministerio de Economía, Industria y Competitividad (España), Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (España), Instituto de Salud Carlos III, Comunidad de Madrid |
| سنة النشر: | 2019 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | GRK2, GPCR, Cardiovascular, Obesity, NAFLD, Insulin resistance, Inhibitors |
| الوصف: | G protein-coupled receptor kinase 2 (GRK2) is a central signaling node involved in the modulation of many G protein-coupled receptors (GPCRs) and also displaying regulatory functions in other cell signaling routes. GRK2 levels and activity have been reported to be enhanced in patients or in preclinical models of several relevant pathological situations, such as heart failure, cardiac hypertrophy, hypertension, obesity and insulin resistance conditions, or non-alcoholic fatty liver disease (NAFLD), and to contribute to disease progression by a variety of mechanisms related to its multifunctional roles. Therefore, targeting GRK2 by different strategies emerges as a potentially relevant approach to treat cardiovascular disease, obesity, type 2 diabetes, or NAFLD, pathological conditions which are frequently interconnected and present as co-morbidities. ; Ministerio de Economía; Industria y Competitividad (MINECO) of Spain (grant SAF2017- 84125-R to FM and CM and SAF2016-80305-P to MS and AMB), CIBERCV-Instituto de Salud Carlos III, Spain (grants CB16/11/00278 and CB16/11/00286 to FM and MS, respectively, co-funded with European FEDER contribution), and Programa de Actividades en Biomedicina de la Comunidad de Madrid |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1663-9812 |
| العلاقة: | Publisher's version; http://dx.doi.org/10.3389/fphar.2019.00112Test; Sí; Frontiers in Pharmacology 10 (2019); http://hdl.handle.net/10261/214705Test; http://dx.doi.org/10.13039/501100010198Test; http://dx.doi.org/10.13039/501100004587Test; http://dx.doi.org/10.13039/100012818Test |
| DOI: | 10.3389/fphar.2019.00112 |
| DOI: | 10.13039/501100010198 |
| DOI: | 10.13039/501100004587 |
| DOI: | 10.13039/100012818 |
| الإتاحة: | https://doi.org/10.3389/fphar.2019.00112Test https://doi.org/10.13039/501100010198Test https://doi.org/10.13039/501100004587Test https://doi.org/10.13039/100012818Test http://hdl.handle.net/10261/214705Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.59974138 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16639812 |
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| DOI: | 10.3389/fphar.2019.00112 |