التفاصيل البيبلوغرافية
| العنوان: |
Body Weight Change During and AfterHospitalization for Acute HeartFailure:Patient Characteristics, Markers of Congestion, and Outcomes Findings From the ASCEND-HF Trial |
| المؤلفون: |
Ambrosy, Andrew P, Cerbin, Lukasz P, Armstrong, Paul W, Butler, Javed, Coles, Adrian, DeVore, Adam D, Dunlap, Mark E, Ezekowitz, Justin A, Felker, G Michael, Fudim, Marat, Greene, Stephen J, Hernandez, Adrian F, O'Connor, Christopher M, Schulte, Philip, Starling, Randall C, Teerlink, John R, Voors, Adriaan A, Mentz, Robert J |
| المصدر: |
JACC Heart Failure, vol 5, iss 1 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2017 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Heart Disease, Clinical Research, Cardiovascular, Clinical Trials and Supportive Activities, Acute Disease, Aged, Dyspnea, Female, Heart Failure, Hospitalization, Humans, Male, Middle Aged, Natriuretic Agents, Natriuretic Peptide, Brain, Treatment Outcome, Urine, Weight Gain, Weight Loss, acute heart failure, body weight, urine output, Cardiorespiratory Medicine and Haematology |
| جغرافية الموضوع: |
1 - 13 |
| الوصف: |
ObjectivesThis study sought to examine the relationships between in-hospital and post-discharge body weight changes and outcomes among patients hospitalized for acute heart failure (AHF).BackgroundBody weight changes during and after hospitalization for AHF and the relationships with outcomeshave not been well characterized.MethodsA post hoc analysis was performed of the ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide and Decompensated Heart Failure) trial, which enrolled patients admitted for AHF regardless of ejection fraction. In-hospital body weight change was defined as the difference between baseline and discharge/day 10, whereas post-discharge body weight change was defined as the difference between discharge/day 10 and day 30. Spearman rankcorrelations of weightchange, urine output (UOP), and dyspnea relief as assessed by a 7-point Likert scale aredescribed. Logistic and Cox proportional hazards regression was used to evaluate the relationship between weightchange and outcomes.ResultsStudy participants with complete body weight data (n= 4,172) had a mean age of 65 ± 14 years, and 66% were male. Ischemic heart disease was reported in 60% of patients and the average ejection fraction was 30 ± 13%. The median change in body weight was-1.0 kg (interquartile range:-2.1 to 0.0 kg) at 24 h and-2.3 kg (interquartile range:-5.0 to-0.7 kg) by discharge/day 10. At hour 24, there was a weak correlation between change in body weight and UOP (r=-0.381), and minimal correlation between body weight change and dyspnea relief (r=-0.096). After riskadjustment, increasing body weight during hospitalization was associated with a 16% increase per kg in the likelihood of 30-day mortality or HF readmission for patients showing weight loss≤1 kg or weight gain during hospitalization (oddsratio per kg increase 1.16, 95% confidence interval [CI]: 1.09 to 1.27; p< 0.001). Among the subset of patientsexperiencing >1-kg increase in body weight post-discharge, increasing body weight was associated with higher risk ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt9vk651dd; https://escholarship.org/uc/item/9vk651ddTest |
| الإتاحة: |
https://escholarship.org/uc/item/9vk651ddTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.D28CF5CD |
| قاعدة البيانات: |
BASE |
