المؤلفون: Covic, Adrian, Säemann, Marcus, Filipov, Jean, Gellert, Ryszard, Gobin, Niels, Jelaković, Bojan, Kabulbayev, Kairat, Luman, Merike, Miglinas, Marius, Mosenzon, Ofri, Okša, Adrián, Radovic, Milan, Rozen-Zvi, Benaya, Ziediņa, Ieva, Tesar, Vladimir

المصدر: Kidney and Blood Pressure Research ; ISSN 1420-4096 1423-0143

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Nephrology

الوصف: Background Chronic kidney disease (CKD) has a global prevalence of 9.1–13.4%. Comorbidities are abundant and may cause and affect CKD. Cardiovascular disease strongly correlates with CKD, increasing the burden of both diseases. Summary As a group of 15 clinical nephrologists primarily practicing in 12 Central/Eastern European countries, as well as Israel and Kazakhstan, herein we review the significant unmet needs for patients with CKD and recommend several key calls-to-action. Early diagnosis and treatment are imperative to ensure optimal outcomes for patients with CKD, with the potential to greatly reduce both morbidity and mortality. Lack of awareness of CKD, substandard indicators of kidney function, suboptimal screening rates, and geographical disparities in reimbursement often hamper access to effective care. Key Messages Our key calls-to-action to address these unmet needs, thus improving the standard of care for patients with CKD, are: increase disease awareness, such as through education; encourage provision of financial support for patients; develop screening algorithms; revisit primary care physician referral practices; and create epidemiological databases that rectify the paucity of data on early-stage disease. By focusing attention on early detection, diagnosis, and treatment of high-risk and early-stage CKD populations we aim to reduce the burdens, progression, and mortality of CKD.

الإتاحة: https://doi.org/10.1159/000538165Test

المؤلفون: Fistrek Prlic, Margareta, Coric, Marijana, Calabresi, Laura, Pavanello, Chiara, Mosca, Lorena, Cavallari, Ugo, Vukovic Brinar, Ivana, Karanovic, Sandra, Laganovic, Mario, Jelakovic, Bojan

المصدر: Atherosclerosis Plus ; volume 49, page 28-31 ; ISSN 2667-0895

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Internal Medicine

الإتاحة: https://doi.org/10.1016/j.athplu.2022.05.005Test
https://api.elsevier.com/content/article/PII:S2667089522000177?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2667089522000177?httpAccept=text/plainTest

المؤلفون: Brguljan, J, Chazova, I E, Gaciong, Z, Simic, D, Vajer, P, Zelveian, P, Jelakovic, B

المصدر: European Heart Journal ; volume 42, issue Supplement_1 ; ISSN 0195-668X 1522-9645

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Objective To assess the efficacy of ambulatory blood pressure (BP) lowering with perindopril/amlodipine (dual SPC arm) and perindopril/amlodipine/indapamide (triple SPC arm) in newly diagnosed and uncontrolled hypertensive patients. Design and method: 450 adults with essential hypertension were assessed in the interventional, open-label, prospective, international, multicentre PRECIOUS trial. Treatment duration was 16 weeks, divided into four treatment periods. ABPM was performed at the baseline and end of the study (prior to the visit 1 and 5), with a validated automated portable BP-measuring device (Mobil-O-Graph PWA) worn on the non-dominant arm for a 24-hour period, measuring BP in 20 minutes interval during the day and 30 minutes interval during the night. At inclusion, naïve or patients uncontrolled on previous mono or dual therapy (other than perindopril/amlodipine (P/A)) were assigned to dual SPC arm with initial dose of 4/5 mg P/A. Those uncontrolled on previous dual or triple therapy were assigned to triple SPC arm with initial dose of 4/5/1.25 mg perindopril/amlodipine/indapamide (P/A/I). If office BP control was not reached, the initial dose was up titrated in 4-week intervals to 8/5 mg, 8/10 mg P/A or 8/10/2.5 mg P/A/I in dual SPC arm and to 8/5/2.5 mg, or 8/10/2.5 mg P/A/I in triple SPC arm. Results After 16 weeks of treatment the decrease in average ambulatory BP was −16.1/−10.8 mmHg (from 142.8/92.6 mmHg to 125.1/80.8 mmHg) in dual SPC arm and −21.8/−13.5 mmHg (from 147.3/93.3 mmHg to 124.2/79.0 mmHg) in triple SPC arm. The relative reductions in ambulatory BP were −11.1%/−11.3% in dual and −14.5%/−14.2% in triple SPC arm. The absolute as well as relative ABPM reductions were higher for the awake-time BP. All ambulatory BP reductions were statistically significant in both arms (p<0.001). 71% of patients reached the normal 24h SBP levels and 45.6% the normal 24h DBP levels. At the end of the trial, the mean dose of perindopril was 6.4±2.0 mg and of amlodipine 6.5±2.3 mg in dual SPC ...

الإتاحة: https://doi.org/10.1093/eurheartj/ehab724.2361Test
https://academic.oup.com/eurheartj/article-pdf/42/Supplement_1/ehab724.2361/41058498/ehab724.2361.pdfTest

المؤلفون: Verstraeten, Aline, Perik, Melanie H.A.M., Baranowska, Anna A., Meester, Josephina A.N., Van Den Heuvel, Lotte, Bastianen, Jarl, Kempers, Marlies, Krapels, Ingrid P.C., Maas, Angela, Rideout, Andrea, Vandersteen, Anthony, Sobey, Glenda, Johnson, Diana, Fransen, Erik, Ghali, Neeti, Webb, Tom, Al-Hussaini, Abtehale, de Leeuw, Peter, Delmotte, Philippe, Lopez-Sublet, Marilucy, Pappaccogli, Marco, Sprynger, Muriel, Toubiana, Laurent, Van Laer, Lut, Van Dijk, Fleur S., Vikkula, Miikka, Samani, Nilesh J., Persu, Alexandre, Adlam, David, Loeys, Bart, Beauloye, Christophe, Chenu, Patrick, Hammer, Frank, Goffette, Pierre, Astarci, Parla, Peeters, André, Verhelst, Robert, Van der Niepen, Patricia, Van Tussenbroek, Frank, De Backer, Tine, Gevaert, Sofie, Hemelsoet, Dimitri, Defreyne, Luc, Heuten, Hilde, Yperzeele, Laetitia, Van der Zijden, Thijs, Lengelé, Jean-Philippe, Krzesinski, Jean-Marie, Verhamme, Peter, Vanassche, Thomas, Scoppettuolo, Pasquale, Wautrecht, Jean-Claude, Jelaković, Bojan, Dika, Zivka, Maria Bruno, Rosa, Taddei, Stefano, Romanini, Caterina, Petrucci, Ilaria, Rabbia, Franco, Di Monaco, Silvia, Paolo Rossi, Gian, Lerco, Silvia, Minuz, Pietro, Mansueto, Giancarlo, De Marchi, Sergio, Marcon, Denise, Kroon, Bram, Spiering, Wilko, van den Born, Bert-Jan, Poch, Esteban, Montagud-Marrahi, Enrique, Molina, Alicia, Guillen, Elena, Burrel, Marta, Wuerzner, Gregor, Mazzolai, Lucia, Buso, Giacomo, European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI), missing

المصدر: CIRCULATION ; ISSN: 0009-7322 ; ISSN: 1524-4539

مصطلحات موضوعية: Medicine and Health Sciences, Physiology (medical), Cardiology and Cardiovascular Medicine, coronary artery disease, fibromuscular dysplasia, genetics, Loeys-Dietz syndrome

وصف الملف: application/pdf

العلاقة: https://biblio.ugent.be/publication/8732829Test; http://hdl.handle.net/1854/LU-8732829Test; http://dx.doi.org/10.1161/circulationaha.120.045946Test; https://biblio.ugent.be/publication/8732829/file/8732830Test

الإتاحة: https://doi.org/10.1161/circulationaha.120.045946Test
https://biblio.ugent.be/publication/8732829Test
http://hdl.handle.net/1854/LU-8732829Test
https://biblio.ugent.be/publication/8732829/file/8732830Test

المؤلفون: Williams, Bryan, Mancia, Giuseppe, Spiering, Wilko, Rosei, Enrico Agabiti, Azizi, Michel, Burnier, Michel, Clement, Denis L., Coca, Antonio, De Simone, Giovanni, Dominiczak, Anna, Kahan, Thomas, Mahfoud, Felix, Redon, Josep, Ruilope, Luis, Zanchetti, Alberto, Kerins, Mary, Kjeldsen, Sverre E., Kreutz, Reinhold, Laurent, Stephane, Lip, Gregory Y.H., McManus, Richard, Narkiewicz, Krzysztof, Ruschitzka, Frank, Schmieder, Roland E., Shlyakhto, Evgeny, Tsioufis, Costas, Aboyans, Victor, Desormais, Ileana, Windecker, Stephan, Agewall, Stefan, Barbato, Emanuele, Bueno, Héctor, Collet, Jean Philippe, Coman, Ioan Mircea, Dean, Veronica, Delgado, Victoria, Fitzsimons, Donna, Gaemperli, Oliver, Hindricks, Gerhard, Iung, Bernard, Jüni, Peter, Katus, Hugo A., Knuuti, Juhani, Lancellotti, Patrizio, Leclercq, Christophe, McDonagh, Theresa A., Piepoli, Massimo Francesco, Ponikowski, Piotr, Richter, Dimitrios J., Roffi, Marco, Simpson, Iain A., Sousa-Uva, Miguel, Zamorano, Jose Luis, Lurbe, Empar, Bochud, Murielle, Jelakovic, Bojan, Januszewicz, Andrzej, Polonia, Jorge, Van De Borne, Philippe, Borghi, Claudio, Parati, Gianfranco, Manolis, Athanasios, Lovic, Dragan, Benkhedda, Salim, Zelveian, Parounak, Siostrzonek, Peter, Najafov, Ruslan, Pavlova, Olga, De Pauw, Michel, Dizdarevic-Hudic, Larisa, Raev, Dimitar, Karpettas, Nikos, Olsen, Michael Hecht, Shaker, Amin Fouad, Viigimaa, Margus, Baranova, Elena I., Metsärinne, Kaj, Halimi, Jean Michel, Pagava, Zurab, Thomopoulos, Costas, Bertomeu-Martinez, Vicente, Wittekoek, Janneke, Andersen, Karl, Shechter, Michael, Romanova, Tatiana, Bajraktari, Gani, Saade, Georges A., Sakalyte, Gintare, Noppe, Stéphanie, Trušinskis, Kārlis, Vavlukis, Marija, DeMarco, Daniela Cassar, Caraus, Alexandru, Schunkert, Heribert, Aksnes, Tonje Amb, Jankowski, Piotr, Linhart, Aleš, Vinereanu, Dragos, Foscoli, Marina, Dikic, Ana Djordjevic, Filipova, Slavomira, Fras, Zlatko, Burkard, Thilo, Carlberg, Bo, Sdiri, Wissem, Aydogdu, Sinan, Sirenko, Yuriy, Páll, Dénes, Brady, Adrian, Mercuro, Giuseppe, Weber, Thomas, Lazareva, Irina, De Backer, Tine, Sokolovic, Sekib, Chazova, Irina, Pörsti, Ilkka, Denolle, Thierry, Stergiou, George S., Segura, Julian, Miglinas, Marius, Krämer, Bernhard K., Gerdts, Eva, Tykarski, Andrzej, De Carvalho Rodrigues, Manuel, Widimsky, Jiri, Dorobantu, Maria, Brguljan, Jana, Pechère-Bertschi, Antoinette, Gottsäter, Anders, Erdine, Serap

المساهمون: Interne Geneeskunde Vasculaire, MS Interne Geneeskunde, Circulatory Health

مصطلحات موضوعية: Antihypertensive Agents/therapeutic use, Cardiology, Disease Management, Europe, Female, Humans, Hypertension/diagnosis, Male, Societies, Medical, Cardiology and Cardiovascular Medicine, Journal Article, Practice Guideline

وصف الملف: image/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/389058Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/389058Test

المؤلفون: Basic-Jukic, Nikolina, Kirincich, Jason, Jelakovic, Bojan, Kastelan, Zeljko

المصدر: Kidney and Blood Pressure Research ; volume 43, issue 3, page 1034-1041 ; ISSN 1420-4096 1423-0143

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Nephrology

الوصف: Background/Aims: Renal transplant recipients are exposed to immunosuppressive treatment which may increase the risk for developing malignancies. Limited data exists concerning the occurrence of multiple primary malignancies (MPM) in renal transplant patients. Methods: All the patients who received a renal allograft at our institution from 1973 to 2017 were included in this investigation. Data from patients with more MPM were obtained from the charts and medical records. Malignancies were categorized as synchronous if the interval between occurrences was less than or equal to 6 months and metachronous if the interval was more than 6 months. Results: Out of the 1884 patients who received a renal allograft, 164 (8.7%) developed a malignant tumor. Twenty-two patients (13.4%; 6 females, 16 males) developed MPM, 7 synchronous (31.8%) and 15 metachronous types (68.2%). The most common initial primary tumors were skin cancers (8) and kidney cancers (3). Furthermore, skin cancers were the most common second primary malignancies (9). Log-rank analysis revealed significantly better survival in the synchronous group (113.3 months) than in the metachronous group (24.6 months) (p=0.04). Conclusion: MPM are more frequent in renal transplant recipients than in the general population. It is associated with a high mortality rate, especially in the metachronous group. An increased awareness and frequent screening tests are necessary when managing this condition.

الإتاحة: https://doi.org/10.1159/000490825Test
https://www.karger.com/Article/Pdf/490825Test

المؤلفون: Luka Penezić, Živka Dika, Bojan Jelaković, Nikolina Bukal, Dražen Pekov

المصدر: Blood pressure. 30(6)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Renal function, Dissection (medical), Fibromuscular dysplasia, resistant hypertension, fibromuscular dysplasia, artery dissection, renal infarction, renal colic, Renal Artery, Internal Medicine, medicine, Fibromuscular Dysplasia, Humans, Right Renal Artery, Renal colic, Kidney, medicine.diagnostic_test, business.industry, General Medicine, medicine.disease, Nephrectomy, Surgery, medicine.anatomical_structure, Hypertension, Renovascular, Infarction, Angiography, Hypertension, Kidney Diseases, medicine.symptom, Cardiology and Cardiovascular Medicine, business

الوصف: We report the case of 39-year-old Caucasian man presenting in emergency department with new onset of severe hypertension with hypokalaemia eight weeks after renal colic. Patient was referred to a hypertension unit for further investigation. Hormonal analysis confirmed secondary aldosteronism and slightly impaired kidney function. Imaging revealed smaller right kidney, ‘string of beads appearance’ of distal part of right renal artery, a short zone of dissection and renal infarction. Renal scintigraphy showed significant blood flow reduction and severe func tional damage of the right kidney. Despite multidrug antihypertensive treatment patient’s hyper tension was resistant and target organ damage evolved. After initial patient’s refusal, he was later successfully treated with laparoscopic simple nephrectomy. Histopathological analysis con firmed renal artery dissection and medial fibroplasia. Thereafter, hypertension was controlled with trandalopril monotherapy. This is a first case report of the patient with renovascular multi focal fibromuscular dysplasia, dissection and renal infarction whose diagnosis of the disease was confirmed by angiography and histopathologic analysis. Resistant hypertension was successfully treated with nephrectomy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad719ff371a562ce2c55c217eb10fb4Test
https://pubmed.ncbi.nlm.nih.gov/34791979Test

المؤلفون: Basic-Jukic, Nikolina, Gulin, Marijana, Hudolin, Tvrtko, Kastelan, Zeljko, Katalinic, Lea, Coric, Marijana, Veda, Marija Varnai, Ivkovic, Vanja, Kes, Petar, Jelakovic, Bojan

المصدر: Kidney and Blood Pressure Research ; volume 41, issue 6, page 781-793 ; ISSN 1420-4096 1423-0143

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Nephrology, General Medicine

الوصف: Background/Aims: Delayed graft function (DGF) is associated with adverse outcomes after renal transplantation. Bone morphogenetic protein-2 (BMP-2) is involved in both endothelial function and immunological events. We compared expression of BMP-2 in epigastric artery of renal transplant recipients with immediate graft function (IGF) and DGF. Methods: 79 patients were included in this prospective study. Patients were divided in IGF group (64 patients) and DGF group (15 patients). BMP-2 expression in intima media (BMP2m) and endothelium (BMP2e) of epigastric artery was assessed by immunohistochemistry. Results: Lower intensity of BMP2e staining was recorded in DGF compared to IGF. In DGF patients, 93% had no expression of BMP2e and 7% had 1 st grade expression, compared to 45% and 41% in IGF group, respectively (P=0.001) (P<0.001 for no expression and P = 0.015 for 1 st grade expression). Patients who had BMP2e staining positive had lower odds for DGF (OR 0.059 [0.007, 0.477]) and this remained significant even after adjustment for donor and recipient variables, cold ischemia time, and immunological matching (OR 0.038 [0.003, 0.492]). Conclusions: Our results demonstrate that BMP-2 expression in endothelial cells of epigastric arteries may predict development of DGF.

الإتاحة: https://doi.org/10.1159/000450568Test
https://www.karger.com/Article/Pdf/450568Test

المؤلفون: Nikolaos Ioakeimidis, Konstantinos Tsioufis, Jacek Wolf, Margus Viigimaa, Konstantinos Stavropoulos, Athanasios J. Manolis, Charalambos Vlachopoulos, Andres Kotsar, Dimitios Terentes-Printzios, Michael Doumas, Giuseppe Mancia, Urmo Kiitam, Reinhold Kreutz, Dragan Lovic, Konstantinos Imprialos, Krzysztof Narkiewicz, Bojan Jelaković

المصدر: Journal of Hypertension. 38:1220-1234

مصطلحات موضوعية: Male, medicine.medical_specialty, Physiology, Adrenergic beta-Antagonists, Cardiology, Coronary Artery Disease, Disease, 030204 cardiovascular system & hematology, Nebivolol, Impotence, Vasculogenic, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Erectile Dysfunction, Risk Factors, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Testosterone, Endothelium, 030212 general & internal medicine, Endothelial dysfunction, Antihypertensive Agents, Societies, Medical, business.industry, Penile Erection, Arteries, Phosphodiesterase 5 Inhibitors, Atherosclerosis, medicine.disease, Sexual Dysfunction, Physiological, Sexual dysfunction, Erectile dysfunction, Cardiovascular Diseases, Hypertension, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Dyslipidemia, medicine.drug

الوصف: Sexual health is an integral part of overall health, and an active and healthy sexual life is an essential aspect of a good life quality. Cardiovascular disease and sexual health share common risk factors (arterial hypertension, diabetes mellitus, dyslipidemia, obesity, and smoking) and common mediating mechanisms (endothelial dysfunction, subclinical inflammation, and atherosclerosis). This generated a shift of thinking about the pathophysiology and subsequently the management of sexual dysfunction. The introduction of phosphodiesterase type 5 inhibitors revolutionized the management of sexual dysfunction in men. This article will focus on erectile dysfunction and its association with arterial hypertension. This update of the position paper was created by the Working Group on Sexual Dysfunction and Arterial Hypertension of the European Society of Hypertension. This working group has been very active during the last years in promoting the familiarization of hypertension specialists and related physicians with erectile dysfunction, through numerous lectures in national and international meetings, a position paper, newsletters, guidelines, and a book specifically addressing erectile dysfunction in hypertensive patients. It was noted that erectile dysfunction precedes the development of coronary artery disease. The artery size hypothesis has been proposed as a potential explanation for this observation. This hypothesis seeks to explain the differing manifestation of the same vascular condition, based on the size of the vessels. Clinical presentations of the atherosclerotic and/or endothelium disease in the penile arteries might precede the corresponding manifestations from larger arteries. Treated hypertensive patients are more likely to have sexual dysfunction compared with untreated ones, suggesting a detrimental role of antihypertensive treatment on erectile function. The occurrence of erectile dysfunction seems to be related to undesirable effects of antihypertensive drugs on the penile tissue. Available information points toward divergent effects of antihypertensive drugs on erectile function, with diuretics and beta-blockers possessing the worst profile and angiotensin receptor blockers and nebivolol the best profile.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39c58ab8f901491f2a7e5a7df53a439Test
https://doi.org/10.1097/hjh.0000000000002382Test

المؤلفون: Petar Šušnjara, Ana Stupin, Marija Matasin, Zivka Dika, Ivana Jukić, Bojan Jelaković, B. Krtalic, Luka Kolar, Sandra Karanović, Leon Perić, Ines Drenjančević, Ana Jelaković, Ivo Vincetić

مصطلحات موضوعية: Croatian, Gerontology, Physiology, business.industry, Adult population, Foundation (engineering), language.human_language, skin microvascular reactivity, laser Doppler flowmetry, anthropometric parameters, blood pressure, Internal Medicine, language, Medicine, Cardiology and Cardiovascular Medicine, Reactivity (psychology), business

الوصف: Objective. To assess the forearm skin microvascular reactivity and anthropometric parameters in randomly selected population and seek the differences between a group of people who had elevated blood pressure at the time of measurement and those who were normotensive. Design and method. Total of 148 randomly selected individuals (50 men/98 women) participated in this study. The exclusion criteria were less than 1l of urine collected at 24h, and creatinine values below the reference values. Forthy eight individuals included in this study had arterial hypertension (HT) and 44 had normal arterial blood pressure values (NT). Post-occlusive reactive hyperemia (PORH) in skin microcirculation following 1 minute of vascular occlusion period was assessed using laser Doppler flowmetry. Anthropometric parameters, blood pressure, heart rate were measured, and 24-hour urine was collected to sodium excretion and creatinine measurement. P< 0, 05 was considered statistically significant. Results. Sistolic (SBP), diastolic (DBP) and mean (MAP) arterial blood pressure were significantly higher, while PORH was significantly lower in HT group compared to NT individuals. HT had higher body mass index (BMI) and waist circumference, while there were no differences in heart rate between HT and NT group. In HT individuals, PORH was negatively associated with waist circumference (r=-0, 438), and positively associated with heart rate (r=0, 316). Sodium excretion was positively associated with DBP (r=0, 361). In NT group, PORH was negatively associated with SBP (r=-0, 362) and MAP (r=-0, 37). SBP and MAP were positively associated with BMI (r=0, 484, r=0, 312) and waist circumference (r=0, 421, r=0, 319). Sodium excretion was positively associated with BMI (r=0, 546) and waist circumference (r=0, 523). Analyzes of all individuals together showed that PORH was negatively associated with BMI (r=-0, 253), SBP (r=-0, 274) and MAP (r=-0, 24), while BMI was positively associated with SBP (r=0, 359), DBP (r=0, 219) and MAP (r=0, 312). Conclusions. High blood pressure attenuated microvascular function. Arterial blood pressure is related to obesity (BMI, waist circumference).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85e579797341626f8e6cd67fdadabadTest
https://www.bib.irb.hr/1125667Test