المؤلفون: Changsheng Ma, Zhao Li, Ying Tao, Su Wang, Chengqian Yin, Yu-Long Gao, Zhi-Zhong Li, Yutong Cheng

المصدر: Chinese Medical Journal
Chinese Medical Journal, Vol 131, Iss 20, Pp 2417-2423 (2018)

مصطلحات موضوعية: Male, medicine.medical_specialty, Complex Coronary Heart Disease, medicine.drug_class, medicine.medical_treatment, Myocardial Infarction, lcsh:Medicine, Coronary Artery Disease, 030204 cardiovascular system & hematology, Angina, Coronary artery disease, 03 medical and health sciences, Percutaneous Coronary Intervention, 0302 clinical medicine, Internal medicine, medicine, Humans, cardiovascular diseases, 030212 general & internal medicine, Myocardial infarction, Enoxaparin, Aged, Retrospective Studies, Heparin, business.industry, lcsh:R, Anticoagulant, Anticoagulants, Percutaneous coronary intervention, General Medicine, Thrombolysis, Middle Aged, Unfractionated Heparin, medicine.disease, Conventional PCI, Cardiology, Female, Original Article, business, TIMI

الوصف: Background: Unfractionated heparin (UFH), despite its limitations, has been used as the primary anticoagulant alternative during the percutaneous coronary intervention (PCI). Some studies indicated that intravenous enoxaparin could be an effective and safe option. Our team used enoxaparin alone at one time according to the guidelines (Class IIA) and found a little catheter thrombosis during PCI. We recommend a new anticoagulation strategy using enoxaparin in combination with UFH. Enoxaparin has a more predictable anticoagulant response with no need of repeatedly monitoring anticoagulation during PCI. This retrospective study aimed to evaluate the efficacy and safety of using enoxaparin in combination with UFH in PCI patients with complex coronary artery disease. Methods: Between January 2015 and April 2017, 600 PCI patients who received intravenous UFH at an initial dose of 3000 U plus intravenous enoxaparin at a dose of 0.75 mg/kg (observation group) and 600 PCI patients who received UFH at a dose of 100 U/kg (control group) were consecutively included in this retrospective study. The endpoints were postoperative 48-h thrombolysis in myocardial infarction (TIMI) bleeding and transfusion and 30-day and 1-year major adverse cardio-cerebrovascular events (MACCE). Results: Baseline clinical, angiographic, and procedural characteristics were similar between groups, except there was less stent implantation per patient in the observation group (2.13 vs. 2.25 in the control group, P = 0.002). TIMI bleeding (3.3% vs. 4.7%) showed no significant difference between the observation group and control group. During the 30-day follow-up, the rate of MACCE was 0.9% in the observation group and 1.5% in the control group. There was no significant difference in the rates of MACCE, death, myocardial infarction, target vessel revascularization, cerebrovascular event, and angina within 30 days and 1 year after PCI between groups as well as in the subgroup analysis of transfemoral approach. Conclusions: UFH with sequential enoxaparin has similar anticoagulant effect and safety as UFH in PCI of complex coronary artery disease. Key words: Complex Coronary Heart Disease; Enoxaparin; Percutaneous Coronary Intervention; Unfractionated Heparin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c036e0f5d5f7f1f9259875e2a2e013Test
https://doi.org/10.4103/0366-6999.243559Test

المؤلفون: Lihui Kang, Junping Sun, Yun Gao, Nan Li, Yu-Long Gao, Wang Su, Shihong Li, Yutong Cheng, Xuanzu Chen, Ying Tao, Hong-Hong Liu, Jingmei Zhang, Chengqian Yin, Donghua Zhang, Ji Huang, Xian-Liang Yan, Tao Sun, Xiang-Yu Wu, Zhi-Zhong Li, Zhao Li, Qian Wang, Yun Lin, Xuejian Hou, Su Wang

المصدر: Journal of International Medical Research, Vol 47 (2019)
The Journal of International Medical Research

مصطلحات موضوعية: Male, Acute coronary syndrome, medicine.medical_specialty, China, Medicine (General), medicine.medical_treatment, 030204 cardiovascular system & hematology, safety and cost, Biochemistry, acute coronary syndrome, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, R5-920, Internal medicine, medicine, Humans, In patient, 030212 general & internal medicine, Prospective Studies, Early discharge, Retrospective Studies, business.industry, Incidence, Biochemistry (medical), percutaneous coronary intervention, Percutaneous coronary intervention, Cell Biology, General Medicine, early discharge, Length of Stay, Middle Aged, medicine.disease, Pre-Clinical Research Reports, Prognosis, Patient Discharge, Survival Rate, Conventional PCI, Cardiology, Cost analysis, Female, Patient Safety, business, hospitalization, Follow-Up Studies

الوصف: Objective To evaluate the safety and cost of early discharge compared with ordinary discharge in patients with diabetes mellitus (DM) following percutaneous coronary intervention (PCI) for acute coronary syndrome. Methods We performed a retrospective analysis of prospectively collected data from 474 patients with DM who were discharged from hospital following PCI at a regional center between 2012 and 2015. Results A total of 192 patients (40.5%) were included in the early discharge group and 282 patients (59.5%) were included in the ordinary group. Mortality and morbidity after PCI were recorded. Kaplan–Meier analysis showed similar prognosis between the two groups at 30 days and at 1 year after discharge. However, hospitalization expenses for the regular discharge group were significantly higher than those of the early discharge group (RMB65,750 vs. RMB50,983). Conclusion Our findings demonstrate that early discharge of patients with DM following PCI for acute coronary syndrome is safe compared with ordinary discharge, and may reduce hospitalization costs.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfaa50375dbe86d6c78fd5d91055f7f3Test
https://doaj.org/article/bd746d5442e04b069feb1d0dcd53384aTest

المؤلفون: Jianping Xu, Yan Yao, Yutong Cheng, Yang Liu, Xinguo Wang, Xinbin Liu, Yaguang Zheng, Chunxiao Zhang

المصدر: The Heart Surgery Forum. 20:258

مصطلحات موضوعية: Male, medicine.medical_specialty, medicine.medical_treatment, Coronary Artery Disease, Coronary Angiography, Revascularization, Severity of Illness Index, Coronary artery disease, Percutaneous Coronary Intervention, Internal medicine, medicine, Humans, Retrospective Studies, business.industry, Proportional hazards model, Standard treatment, Hazard ratio, Percutaneous coronary intervention, Drug-Eluting Stents, Middle Aged, medicine.disease, Coronary Vessels, humanities, Confidence interval, Treatment Outcome, Conventional PCI, Cardiology, Female, Surgery, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies

الوصف: Background: With the follow-up extending to 5 years, the outcomes of SYNTAX (Synergy Between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery) trial were comparable between coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) in left-main (LM) patients with intermediate SYNTAX scores of 23–32. A subdivision depending on SYNTAX score will help to identify unsuitable LM patients with intermediate SYNTAX scores to receive PCI treatment. Methods: Between January 2011 and June 2013, 104 patients with LM Coronary Artery Disease (CAD) undergoing PCI were selected retrospectively. We compared clinical outcomes in patients with SYNTAX score

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729e87dc9235911d1cbbe0225d7c9274Test
https://doi.org/10.1532/hsf.1741Test