White Matter Hyperintensities in Alzheimer’s Disease: A Lesion Probability Mapping Study
| العنوان: | White Matter Hyperintensities in Alzheimer’s Disease: A Lesion Probability Mapping Study |
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| المؤلفون: | Edith Hofer, Lukas Pirpamer, Christian Langkammer, Peter Dal-Bianco, Stephan Seiler, Anna Damulina, Walter Struhal, Marco Duering, Reinhold Schmidt, Gerhard Ransmayr, Thomas Benke, Franz Fazekas |
| المصدر: | Journal of Alzheimer's Disease. 68:789-796 |
| بيانات النشر: | IOS Press, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Fluid-attenuated inversion recovery, behavioral disciplines and activities, Cohort Studies, Coronary artery disease, Lesion, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Diabetes mellitus, Internal medicine, mental disorders, Humans, Medicine, Dementia, Longitudinal Studies, Prospective Studies, Registries, Cognitive decline, Aged, Aged, 80 and over, Brain Mapping, medicine.diagnostic_test, business.industry, General Neuroscience, Brain, Magnetic resonance imaging, General Medicine, Middle Aged, medicine.disease, White Matter, Hyperintensity, Psychiatry and Mental health, Clinical Psychology, 030104 developmental biology, Austria, Cardiology, Female, Geriatrics and Gerontology, medicine.symptom, business, 030217 neurology & neurosurgery, Follow-Up Studies |
| الوصف: | Background/objective Higher white matter hyperintensity (WMH) load has been reported in Alzheimer's disease (AD) patients in different brain regions when compared to controls. We aimed to assess possible differences of WMH spatial distribution between AD patients and age-matched controls by means of lesion probability maps. Methods The present study included MRI scans of 130 probable AD patients with a mean age of 73.4±8.2 years from the Prospective Dementia Registry Austria Study and 130 age-matched healthy controls (HC) from the Austrian Stroke Prevention Family Study. Risk factors such as hypertension, diabetes mellitus, hypercholesterolemia, coronary artery disease, and smoking were assessed. Manually segmented FLAIR WMH masks were non-linearly registered to a template and voxel-based probability mapping was performed. Results There were no significant between-group differences in cardiovascular risk factors and WMH volume. AD patients showed a significantly higher likelihood of having WMH in a bilateral periventricular distribution than controls before and after correcting for age, sex, cardiovascular risk factors, and ventricular volume (p≤0.05; threshold-free cluster enhancement corrected). There was no significant association between the periventricular WMH volume and cognitive decline of AD patients. Conclusion In AD, WMH were preferentially found in a periventricular location but the volume of lesions was unrelated to cognitive decline in our study irrespective of lesion location. |
| تدمد: | 1875-8908 1387-2877 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0d9624d2b4a8ceeaaab34665804954Test https://doi.org/10.3233/jad-180982Test |
| رقم الانضمام: | edsair.doi.dedup.....4f0d9624d2b4a8ceeaaab34665804954 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758908 13872877 |
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