دورية أكاديمية
Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fraction ; Miyokart enfarktüsü sonrası geç dönemde plazma matriks metalloproteinaz-8 seviyelerinin sol ventrikül hacimleri ve ejeksiyon fraksiyonu ile ilişkisi
| العنوان: | Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fraction ; Miyokart enfarktüsü sonrası geç dönemde plazma matriks metalloproteinaz-8 seviyelerinin sol ventrikül hacimleri ve ejeksiyon fraksiyonu ile ilişkisi |
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| المؤلفون: | Erkol, Ayhan, Pala, Selçuk, Oduncu, Vecih, Kılıçgedik, Alev, Kızılırmak, Filiz, Karabay, Can Yücel, Güler, Ahmet, Kırma, Cevat |
| سنة النشر: | 2013 |
| المجموعة: | İstanbul Medipol University Institutional Repository (DSpace@Medipol) |
| مصطلحات موضوعية: | Biological Markers/Blood, Cardiac Volume, Coronary Disease, Ejection Fraction, Electrocardiography, Heart Ventricles, Matrix Metalloproteinase 8, Myocardial Infarction/Blood/Enzymology, Miyokart Enfarktüsü, Plazma, Matriks Metalloproteinaz 8, Ejeksiyon Fraksiyonu |
| الوصف: | Objectives: Enhanced matrix metalloproteinase-8 (MMP-8) activity in the early post-myocardial infarction (MI) period has been related to early remodeling. However, it has been demonstrated that plasma MMP-8 level has a biphasic profle, and the relation between the late plasma levels and remodeling is unclear. We evaluated the plasma MMP-8 levels and its correlates 20±3 months after acute MI. Study design: 58 post-MI patients and 26 control subjects underwent quantitative single-photon emission computed tomography (SPECT) and echocardiography. The plasma MMP-8 levels were measured and its correlates were investigated. Results: The MMP-8 levels were signifcantly higher in post-MI patients [median 3.88 ng/ml, interquartile range (1.88-6.43) vs. 0.67 ng/ml (0.34-2.47); p<0.001]. Plasma MMP-8 levels were signifcantly correlated with left ventricular ejection fraction (LVEF) (?=0.34, p=0.009), end diastolic volume index (EDVi) (?=-0.39, p=0.002) and end systolic volume index (ESVi) (?=-0.40, p=0.002). Conclusion: Plasma MMP-8 levels were found to still be high in post-MI patients 20±3 months after the index event. The levels were signifcantly correlated with left ventricular volume indices and LVEF. We speculate that, in contrast to the relation between the higher early MMP-8 activity and the extent of cardiac remodeling, higher late levels may be associated with relative preservation of left ventricular systolic function. ; Amaç: Miyokart enfarktüsü (ME) sonrası erken dönemde artmış matriks metalloproteinaz-8 (MMP-8) aktivitesinin erken yeniden şekillenme ile ilişkisi olduğu bilinmektedir. Ancak MMP8’in bifazik bir profile sahip olduğu gösterilmiştir ve geç dönem plazma seviyeleri ile yeniden şekillenme arasındaki ilişki net değildir. Çalışmamızda ME’nin 20±3 ay sonrasında plazma MMP8 seviyelerini ve klinik parametrelerle olan ilişkisini inceledik. Çalışma planı: Miyokart enfaktüsü geçirmiş 58 hasta ve 26 bireylik kontrol grubuna kantitatif tek-foton emisyon bilgisayarlı tomografi (SPECT) ve ekokardiyografi ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1016-5169 |
| العلاقة: | Archives of the Turkish Society of Cardiology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Erkol, A., Pala, S., Oduncu, V., Kılıçgedik, A., Kızılırmak, F., Karabay, C. Y. . Kırma, C. (2013). Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fraction. Archives of the Turkish Society of Cardiology, 41(7), 617-624. https://dx.doi.org/10.5543/tkda.2013.68625Test; https://hdl.handle.net/20.500.12511/919Test; https://dx.doi.org/10.5543/tkda.2013.68625Test; 41; 617; 624; Q3 |
| DOI: | 10.5543/tkda.2013.68625 |
| الإتاحة: | https://doi.org/20.500.12511/919Test https://doi.org/10.5543/tkda.2013.68625Test https://hdl.handle.net/20.500.12511/919Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.AB4054A2 |
| قاعدة البيانات: | BASE |
| تدمد: | 10165169 |
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| DOI: | 10.5543/tkda.2013.68625 |