التفاصيل البيبلوغرافية
| العنوان: |
Protein Geometry and Placement in the Cardiac Dyad Influence Macroscopic Properties of Calcium-Induced Calcium-Release |
| المؤلفون: |
Antti J. Tanskanen, Joseph L. Greenstein, Alex Chen, Sean X. Sun, Raimond L. Winslow, Joseph L Greenstein |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
http://www.biophysj.org/cgi/rapidpdf/biophysj.106.089425v1.pdfTest. |
| سنة النشر: |
2007 |
| المجموعة: |
CiteSeerX |
| مصطلحات موضوعية: |
Key Words, Ryanodine Receptor, L-type calcium channel, Cardiac dyad, Calcium-induced calcium release, Cardiac Myocyte, Stochastic simulation. * These authors contributed equally to this work Correspondence |
| الوصف: |
In cardiac ventricular myocytes, events crucial to excitation-contraction coupling take place in spatially restricted microdomains known as dyads. The movement and dynamics of calcium (Ca 2+) ions in the dyad have often been described by assigning continuously valued Ca 2+ concentrations to one or more dyadic compartments. However, even at its peak, the estimated number of free Ca 2+ ions present in a single dyad is small ( ~ 10-100 ions). This in turn suggests that modeling dyadic calcium dynamics using laws of mass action may be inappropriate. In this study, we develop a model of stochastic molecular signaling between L-type Ca 2+ channels (LCCs) and ryanodine receptors (RyR2s) that describes: a) known features of dyad geometry, including the space-filling properties of key dyadic proteins; and b) movement of individual Ca 2+ ions within the dyad, as driven by electro-diffusion. The model enables investigation of how local Ca 2+ signaling is influenced by dyad structure, including the configuration of key proteins within the dyad, the location of Ca 2+ binding sites and membrane surface charges. Using this model, we demonstrate that LCC-RyR2 signaling is influenced by both the stochastic dynamics |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.101.2753Test; http://www.biophysj.org/cgi/rapidpdf/biophysj.106.089425v1.pdfTest |
| الإتاحة: |
http://www.biophysj.org/cgi/rapidpdf/biophysj.106.089425v1.pdfTest |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.E38A402C |
| قاعدة البيانات: |
BASE |
