التفاصيل البيبلوغرافية
| العنوان: |
Cardiac magnetic resonance predictors of left ventricular remodelling following acute ST elevation myocardial infarction: The VavirimS study. |
| المؤلفون: |
Pica, Silvia1 (AUTHOR), Crimi, Gabriele2 (AUTHOR), Castelvecchio, Serenella1 (AUTHOR), Pazzanese, Vittorio3 (AUTHOR), Palmisano, Anna3,4 (AUTHOR), Lombardi, Massimo1 (AUTHOR), Tondi, Lara1 (AUTHOR), Esposito, Antonio3,4 (AUTHOR), Ameri, Pietro2 (AUTHOR), Canale, Claudia2 (AUTHOR), Cappelletti, Alberto3 (AUTHOR), Alberti, Luca P.5 (AUTHOR), Tavano, Davide5 (AUTHOR), Camporotondo, Rita6 (AUTHOR), Costantino, Ilaria6 (AUTHOR), Campodonico, Jenness7 (AUTHOR), Pontone, Gianluca7 (AUTHOR), Villani, Alessandra8 (AUTHOR), Gallone, Gianluca Pio8 (AUTHOR), Montone, Rocco A.9 (AUTHOR) |
| المصدر: |
International Journal of Cardiology. Jan2023, Vol. 370, p8-17. 10p. |
| مصطلحات موضوعية: |
*ST elevation myocardial infarction, *CARDIAC magnetic resonance imaging, *VENTRICULAR remodeling, *VENTRICULAR ejection fraction |
| مستخلص: |
Left ventricular (LV) remodelling (REM) ensuing after ST-elevation myocardial infarction (STEMI), has typically been studied by echocardiography, which has limitations, or cardiac magnetic resonance (CMR) in early phase that may overestimate infarct size (IS) due to tissue edema and stunning. This prospective, multicenter study investigated LV-REM performing CMR in the subacute phase, and 6 months after STEMI. patients with first STEMI undergoing successful primary angioplasty were consecutively enrolled. CMR was done at 30-days and 6-months. Primary endpoint was prevalence at 6 months of LV-REM [≥12% increase in LV end-diastolic volume index (LV-REM EDV)]; LV-REM by end-systolic volume index increase ≥12% (LV-REM ESV) was also calculated. Of 325 patients enrolled, 193 with a full set of research-quality CMR images were analyzed. LV-REM EDV and LV-REM ESV were present in 36/193 (19%) and 34/193 (18%) patients, respectively. At follow up, LV ejection fraction (EF) improved in patients with or without LV-REM EDV , whilst it decreased in those with LV-REM ESV (p < 0.001 for interaction). Considering predictors of LV-REM, IS in the highest tertile was clearly separated from the two lower tertiles. In LV-REM EDV , the highest tertile was associated with significantly higher LV-EDV, LV-ESV, and lower EF. In a contemporary cohort of STEMI patients studied by CMR, prevalence of LV-REM EDV was lower than previously reported. Importantly, our data indicate that LV-REM EDV might not be "adverse" per se , but rather "compensatory", being associated with LV-EF improvement at follow-up. Conversely, LV-REM ESV might be an "adverse" phenomenon associated with decreased LV-EF, driven by IS. [Display omitted] • A prospective, multicenter study investigating left ventricular remodelling (LV-REM) in patients with ST elevation myocardial infarction (STEMI) successfully treated with primary PCI who performed cardiac magnetic resonance (CMR) in the subacute phase, and 6 months after the index event; • The prevalence LV-REM, defined as ≥12% increase in LV end-diastolic volume index (LV-REM EDV), was lower than previously reported; • LV-REM assessed by end-systolic volume index increase ≥12% (LV-REM ESV) was associated with decreased left ventricular ejection fraction (LV-EF), driven by infarct size (IS); • LV-REM EDV might not be "adverse" per se , but rather "compensatory", being associated with LV-EF improvement at follow-up;. • Conversely, LV-REM ESV might be an "adverse" phenomenon associated with decreased LV-EF at follow up. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
