دورية أكاديمية
Physical activity and cardiometabolic risk factors in individuals with spinal cord injury: a systematic review and meta-analysis
| العنوان: | Physical activity and cardiometabolic risk factors in individuals with spinal cord injury: a systematic review and meta-analysis |
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| المؤلفون: | Itodo, Oche Adam, Flueck, Joelle Leonie, Raguindin, Peter Francis, Stojic, Stevan, Brach, Mirjam, Perret, Claudio, Minder, Beatrice, Franco, Oscar H., Muka, Taulant, Stucki, Gerold |
| المصدر: | European Journal of Epidemiology 37(4) 335, 365 |
| سنة النشر: | 2022 |
| المجموعة: | Zenodo |
| مصطلحات موضوعية: | spinal cord injury, cardiovascular diseases, physical activity, exercise, cardiac function |
| الوصف: | Physical inactivity in individuals with spinal cord injury (SCI) has been suggested to be an important determinant of increased cardiometabolic disease (CMD) risk. However, it remains unclear whether physically active SCI individuals as compared to inactive or less active individuals have truly better cardiometabolic risk proile. We aimed to systematically review and quantify the association between engagement in regular physical activity and/or exercise interventions and CMD risk factors in individuals with SCI. Four medical databases were searched and studies were included if they were clinical trials or observational studies conducted in adult individuals with SCI and provided information of interest. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was applied to rate the certainty of evidence. Of 5816 unique citations, 11 randomized clinical trials, 3 non-randomized trial and 32 cross-sectional studies comprising more than 5500 SCI individuals were included in the systematic review. In meta-analysis of RCTs and based on evidence of moderate certainty, physical activity in comparison to control intervention was associated with: (i) better glucose homeostasis proile [WMD of glucose, insulin and Assessment of Insulin Resistance (HOMA-IR) were − 3.26 mg/dl (95% CI − 5.12 to − 1.39), − 3.19 μU/ml (95% CI − 3.96 to − 2.43)] and − 0.47 (95% CI − 0.60 to − 0.35), respectively], and (ii) improved cardiorespiratory itness [WMD of relative and absolute oxygen uptake relative (VO2) were 4.53 ml/kg/min (95% CI 3.11, 5.96) and 0.26 L/min (95% CI 0.21, 0.32) respectively]. No diferences were observed in blood pressure, heart rate and lipids (based on evidence of low/moderate certainty). In meta-analysis of cross-sectional studies and based on the evidence of very low to low certainty, glucose [WMD − 3.25 mg/dl (95% CI − 5.36, − 1.14)], insulin [− 2.12 μU/ml (95% CI − 4.21 to − 0.03)] and total cholesterol [WMD − 6.72 mg/dl (95% CI − 13.09, − 0.34)] were lower and HDL [WMD 3.86 mg/dl ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://zenodo.org/communities/loryTest; https://zenodo.org/communities/lory_uniluTest; https://zenodo.org/record/8032568Test; https://doi.org/10.5281/zenodo.8032568Test; oai:zenodo.org:8032568 |
| DOI: | 10.5281/zenodo.8032568 |
| الإتاحة: | https://doi.org/10.5281/zenodo.8032568Test https://doi.org/10.1007/s10654-022-00859-4Test https://doi.org/10.5281/zenodo.8032567Test https://zenodo.org/record/8032568Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by/4.0/legalcodeTest |
| رقم الانضمام: | edsbas.F0B81176 |
| قاعدة البيانات: | BASE |
| DOI: | 10.5281/zenodo.8032568 |
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