التفاصيل البيبلوغرافية
| العنوان: |
PTP1B: a double agent in metabolism and oncogenesis |
| المؤلفون: |
Yip, Shu-Chin1, Saha, Sayanti1, Chernoff, Jonathan1 Jonathan.Chernoff@fccc.edu |
| المصدر: |
Trends in Biochemical Sciences. Aug2010, Vol. 35 Issue 8, p442-449. 8p. |
| مصطلحات موضوعية: |
*PROTEIN-tyrosine phosphatase, *CARCINOGENESIS, *METABOLISM, *CELLULAR signal transduction, *BREAST cancer treatment, *TREATMENT of diabetes, *OBESITY treatment |
| مستخلص: |
PTP1B, a non-transmembrane protein tyrosine phosphatase that has long been studied as a negative regulator of insulin and leptin signaling, has received renewed attention as an unexpected positive factor in tumorigenesis. Here, we highlight how views of this enzyme have evolved from regarding it as a simple metabolic off-switch to a more complex view of PTP1B as an enzyme that can play both negative and positive roles in diverse signaling pathways. These dual characteristics make PTP1B a particularly attractive therapeutic target for diabetes, obesity, and perhaps breast cancer. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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