التفاصيل البيبلوغرافية
| العنوان: |
Efficacy of inhaled N-acetylcysteine monotherapy in patients with early stage idiopathic pulmonary fibrosis. |
| المؤلفون: |
HOMMA, SAKAE, AZUMA, ARATA, TANIGUCHI, HIROYUKI, OGURA, TAKASHI, MOCHIDUKI, YOSHIRO, SUGIYAMA, YUKIHIKO, NAKATA, KOICHIRO, YOSHIMURA, KUNIHIKO, TAKEUCHI, MASAHIRO, KUDOH, SHOJI |
| المصدر: |
Respirology; Apr2012, Vol. 17 Issue 3, p467-477, 11p |
| مصطلحات موضوعية: |
IDIOPATHIC pulmonary fibrosis, TRIPEPTIDES, CARBON monoxide, VITAL capacity (Respiration), RANDOMIZED controlled trials, JAPANESE people |
| مستخلص: |
ABSTRACT Background and objective: Idiopathic pulmonary fibrosis (IPF) is a fatal disorder for which there are currently no specific or effective medical treatments. A multicentre, prospective, randomized, controlled clinical trial was conducted to assess the efficacy of inhaled N-acetylcysteine (NAC) monotherapy in Japanese patients with early stage IPF. Methods: Eligible patients had well-defined IPF of mild-to-moderate severity, with no desaturation on exercise. Of 100 patients screened, 76 were randomly assigned to an NAC treatment group (group A; n = 38) that received 352.4 mg of NAC by inhalation twice daily or to a control group (group B; n = 38) that received no therapy. The primary endpoint was the change from baseline in forced vital capacity (FVC) at 48 weeks. Results: There were no significant overall differences in the change in FVC between groups A and B. Post hoc exploratory analyses showed that NAC therapy was associated with stability of FVC in (i) a subset of patients with initial FVC <95% of predicted ( n = 49; difference in FVC decline 0.12 L; P = 0.02) and (ii) in patients with initial diffusing capacity of carbon monoxide <55% of predicted ( n = 21; difference in FVC decline 0.17 L; P = 0.009). Conclusions: These findings indicate that NAC monotherapy may have some beneficial effect in patients with early stage IPF. Further trials in more select IPF populations with progressive disease are required to prove the efficacy of inhaled NAC. [ABSTRACT FROM AUTHOR] |
|
Copyright of Respirology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
