التفاصيل البيبلوغرافية
| العنوان: |
Targeted peripheral focused ultrasound stimulation attenuates obesity-induced metabolic and inflammatory dysfunctions. |
| المؤلفون: |
Huerta, Tomás S., Devarajan, Alex, Tsaava, Tea, Rishi, Arvind, Cotero, Victoria, Puleo, Christopher, Ashe, Jeffrey, Coleman, Thomas R., Chang, Eric H., Tracey, Kevin J., Chavan, Sangeeta S. |
| المصدر: |
Scientific Reports; 3/3/2021, Vol. 11 Issue 1, p1-12, 12p |
| مصطلحات موضوعية: |
OBESITY, MORTALITY, CARBOHYDRATES, ADIPOKINES, BODY weight |
| مستخلص: |
Obesity, a growing health concern, is associated with an increased risk of morbidity and mortality. Chronic low-grade inflammation is implicated in obesity-driven metabolic complications. Peripheral focused ultrasound stimulation (pFUS) is an emerging non-invasive technology that modulates inflammation. Here, we reasoned that focused ultrasound stimulation of the liver may alleviate obesity-related inflammation and other comorbidities. After 8 weeks on a high-fat high-carbohydrate "Western" diet, C57BL/6J mice were subjected to either sham stimulation or focused ultrasound stimulation at the porta hepatis. Daily liver-focused ultrasound stimulation for 8 weeks significantly decreased body weight, circulating lipids and mitigated dysregulation of adipokines. In addition, liver-focused ultrasound stimulation significantly reduced hepatic cytokine levels and leukocyte infiltration. Our findings demonstrate the efficacy of hepatic focused ultrasound for alleviating obesity and obesity-associated complications in mice. These findings suggest a previously unrecognized potential of hepatic focused ultrasound as a possible novel noninvasive approach in the context of obesity. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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