دورية أكاديمية
RASD2, MYH9, and CACNG2 Genes at Chromosome 22q12 Associated with the Subgroup of Schizophrenia with Non-Deficit in Sustained Attention and Executive Function
| العنوان: | RASD2, MYH9, and CACNG2 Genes at Chromosome 22q12 Associated with the Subgroup of Schizophrenia with Non-Deficit in Sustained Attention and Executive Function |
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| المؤلفون: | Liu, Yu-Li, Fann, Cathy Shen-Jang, Liu, Chih-Min, Chen, Wei J., Wu, Jer-Yuarn, Hung, Shuen-Iu, Chen, Chun-Houh, Jou, Yuh-Shan, Liu, Shi-Kai, Hwang, Tzung-Jeng, Hsieh, Ming H., Chang, Chien Ching, Yang, Wei-Chih, Lin, Jin-Jia, Chou, Frank Huang-Chih, Faraone, Stephen V., Tsuang, Ming T., Hwu, Hai-Gwo |
| المصدر: | Biological Psychiatry ; 64 ; 9 ; 789 ; 796 |
| بيانات النشر: | Elsevier BV |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Biological Psychiatry, CACNG2, candidate gene, endophenotype, MYH9, RASD2, schizophrenia |
| الوصف: | Background: In a previous linkage study of schizophrenia that included Taiwanese samples, the marker D22S278 (22q12.3) was significantly linked to schizophrenia (p .001). Methods: We conducted fine mapping of the implicated genomic region, with 47 validated single nucleotide polymorphism (SNP) markers around 1 Mb of D22S278, in a Taiwanese sample of 218 pedigrees with at least 2 siblings affected with schizophrenia. We examined the association of these SNPs and their haplotypes with schizophrenia and with subgroups defined by the presence and absence of deficits in sustained attention as assessed by undegraded and degraded continuous performance tests (CPTs). We also examined subgroups defined by deficits in categories achieved in the Wisconsin Card Sort Test (WCST). Results: Three of five candidate vulnerability genes (RASD2, APOL5, MYH9, EIF3S7, and CACNG2), which had marginally significant associations with schizophrenia, had significant associations with schizophrenic patients who did not have deficits in sustained attention on the undegraded CPT (RASD2 gene SNP rs736212; p .0008 with single locus analysis) and the degraded CPT (MYH9 gene haplotype 1-1-1-1 of SNP rs3752463 - rs1557540 - rs713839 - rs739097; p .0059 with haplotype analysis). We also found a significant association for patients who showed no deficits in executive function as measured by categories achieved in the WCST (CACNG2 gene haplotype 2-1-1-1 of SNP rs2267360 - rs140526 - rs1883987 - rs916269; p .0163 with haplotype analysis). Conclusions: The genes RASD2, MYH9, and CACNG2 might be vulnerability genes for neuropsychologically defined subgroups of schizophrenic patients. ; AM ; Upstate Medical University ; Psychiatry ; N/A |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0006-3223 |
| العلاقة: | S0006322308005672; http://hdl.handle.net/20.500.12648/7005Test |
| DOI: | 10.1016/j.biopsych.2008.04.035 |
| الإتاحة: | https://doi.org/20.500.12648/7005Test https://doi.org/10.1016/j.biopsych.2008.04.035Test https://hdl.handle.net/20.500.12648/7005Test |
| حقوق: | Attribution-NonCommercial-NoDerivatives 4.0 International ; https://www.elsevier.com/tdm/userlicense/1.0Test/ ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.95A95BF7 |
| قاعدة البيانات: | BASE |
| تدمد: | 00063223 |
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| DOI: | 10.1016/j.biopsych.2008.04.035 |