التفاصيل البيبلوغرافية
العنوان:
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array
المؤلفون:
Artitaya Lophatananon , W. Ryan Diver , Stig E. Bojesen , Roman Corral , Fredrick R. Schumacher , Stephen J. Chanock , Shannon K. McDonnell , Graham G. Giles , Craig C. Teerlink , Douglas F. Easton , Cezary Cybulski , Brian E. Henderson , Judith A. Clements , Ali Amin Al Olama , Francois Bacot , David P. Dearnaley , Elio Riboli , Peter Klarskov , Daniel Vincent , Rosemary A. Wilkinson , Danielle M. Karyadi , Michelle Guy , Vincent Khoo , Christopher A. Haiman , Afshan Siddiq , M. Andreas Røder , Amit Joshi , Jong Y. Park , Walther Vogel , Henrik Grönberg , Angela Cox , Rudolf Kaaks , Nora Pashayan , Timothy J. Key , C. R. J. Woodhouse , Jarmo Virtamo , Meredith Yeager , Malgorzata Tymrakiewicz , Sune F. Nielsen , Richard B. Hayes , Johanna Schleutker , Gianluca Severi , Robert Huddart , Wei Zheng , Thomas A. Sellers , Melanie Maranian , Shahana Ahmed , David E. Neal , Daniel Leongamornlert , Zsofia Kote-Jarai , Tiina Wahlfors , Loic Le Marchand , Kay-Tee Khaw , Tokhir Dadaev , Lisa A. Cannon-Albright , Janet L. Stanford , William J. Blot , Andy C. H. Lee , Freddie C. Hamdy , Siqun L. Zheng , Rosalind A. Eeles , Alison M. Dunning , Mariana C. Stern , Melissa C. Southey , Don M. Conroy , Kenneth Muir , Ahva Shahabi , Alan Horwich , Gerald L. Andriole , Antje E. Rinckleb , Srilakshmi Srinivasan , Tim Dudderidge , Joe Dennis , Radka Kaneva , Vanio Mitev , Angela Morgan , Sue A. Ingles , Adam S. Kibel , Markus Aly , Koveela Govindasami , Maya Ghoussaini , Jenny L Donovan , Manuel R. Teixeira , Emma J. Sawyer , Sara Lindström , Jiangfeng Xu , Maren Weischer , Ed Dicks , Jyotsna Batra , S Jugurnauth-Little , Hui-Yi Lin , Suzanne Kolb , Lisa B. Signorello , Dallas R. English , Antonis C. Antoniou , Federico Canzian , Anssi Auvinen , Mia M. Gaudet , Paula Paulo , Paul D.P. Pharoah , Heiko Müller , Qiuyin Cai , Børge G. Nordestgaard , Esther M. John , Sonja I. Berndt , D J Schaid , Daniele Campa , Chris Ogden , Colin Cooper , Craig Luccarini , Jan Lubinski , Elaine A. Ostrander , Ruth C. Travis , Dominika Wokołorczyk , John L. Hopper , Sofia Maia , Sara Benlloch , Chris Parker , Erika M. Kwon , Nicholas van As , Caroline Baynes , C. Slavov , Teuvo L.J. Tammela , Ethan M. Lange , Daniel C. Tessier , David J. Hunter , Dietrich Rothenbacher , Robert A. Stephenson , Liesel M. FitzGerald , Christiane Maier , Hermann Brenner , Kathleen A. Cooney , Graham A. Colditz , Felicity Lose , Edward J. Saunders , Demetrius Albanes , Stephen N. Thibodeau , Fredrik Wiklund , Amanda B. Spurdle , Jan Adolfsson , Susan M. Gapstur , Peter Kraft , Bettina F. Drake , Alan Thompson
المصدر:
Nature Genetics
سنة النشر:
2016
مصطلحات موضوعية:
Male , genetic association , genotype , Genome-wide association study , Bioinformatics , genetic risk , developed country , Prostate cancer , 0302 clinical medicine , Risk Factors , Genotype , Cooperative Behavior , breast cancer , cancer prognosis , cancer susceptibility , cell adhesion , cell cycle arrest , chromosome 14 , chromosome 2 , double stranded DNA break , embryo development , extracellular matrix , gene frequency , gene linkage disequilibrium , genetic predisposition , Gleason score , heterozygote , human , intron , priority journal , promoter region , prostate cancer , quality control , regulator gene , Oligonucleotide Array Sequence Analysis , 0303 health sciences , education.field_of_study , 3. Good health , 030220 oncology & carcinogenesis , Population , Single-nucleotide polymorphism , Biology , ta3111 , Polymorphism, Single Nucleotide , 03 medical and health sciences , Meta-Analysis as Topic , Genetics , medicine , Humans , Genetic Predisposition to Disease , education , Genotyping , 030304 developmental biology , Case-control study , Cancer , Prostatic Neoplasms , medicine.disease , ta3122 , Genetic Loci , Case-Control Studies , Genome-Wide Association Study
الوصف:
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10(-8)). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.
اللغة:
English
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc5d5f82460009b403d064c3a16e687Test https://doi.org/10.1038/ng.2560Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....2dc5d5f82460009b403d064c3a16e687
قاعدة البيانات:
OpenAIRE
