Genome-wide association studies identify four ER negative-specific breast cancer risk loci.

التفاصيل البيبلوغرافية
العنوان:	Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
المؤلفون:	Garcia Closas M, Couch FJ, Lindstrom S, Michailidou K, Schmidt MK, Brook MN, Orr N, Rhie SK, Riboli E, Feigelson HS, Le Marchand L, Buring JE, Eccles D, Miron P, Fasching PA, Brauch H, Chang Claude J, Carpenter J, Godwin AK, Nevanlinna H, Giles GG, Cox A, Hopper JL, Bolla MK, Wang Q, Dennis J, Dicks E, Howat WJ, Schoof N, Bojesen SE, Lambrechts D, Broeks A, Andrulis IL, Guénel P, Burwinkel B, Sawyer EJ, Hollestelle A, Fletcher O, Winqvist R, Brenner H, Mannermaa A, Hamann U, Meindl A, Lindblom A, Zheng W, Devillee P, Goldberg MS, Lubinski J, Kristensen V, Swerdlow A, Anton Culver H, Dörk T, Muir K, Matsuo K, Wu AH, Radice P, Teo SH, Shu XO, Blot W, Kang D, Hartman M, Sangrajrang S, Shen CY, Southey MC, Park DJ, Hammet F, Stone J, Veer LJ, Rutgers EJ, Lophatananon A, Stewart Brown S, Siriwanarangsan P, Peto J, Schrauder MG, Ekici AB, Beckmann MW, Dos Santos Silva I, Johnson N, Warren H, Tomlinson I, Kerin MJ, Miller N, Marme F, Schneeweiss A, Sohn C, Truong T, Laurent Puig P, Kerbrat P, Nordestgaard BG, Nielsen SF, Flyger H, Milne RL, Perez JI, Menéndez P, Müller H, Arndt V, Stegmaier C, Lichtner P, Lochmann M, Justenhoven C, Ko YD, Gene ENvironmental Interaction, breast CAncer Network, Muranen TA, Aittomäki K, Blomqvist C, Greco D, Heikkinen T, Ito H, Iwata H, Yatabe Y, Antonenkova NN, Margolin S, Kataja V, Kosma VM, Hartikainen JM, Balleine R, kConFab Investigators, Tseng CC, Berg DV, Stram DO, Neven P, Dieudonné AS, Leunen K, Rudolph A, Nickels S, Flesch Janys D, Peterlongo P, Peissel B, Bernard L, Olson JE, Wang X, Stevens K, Severi G, McLean C, Coetzee GA, Feng Y, Henderson BE, Schumacher F, Bogdanova NV, Labrèche F, Dumont M, Yip CH, Taib NA, Cheng CY, Shrubsole M, Long J, Pylkäs K, Jukkola Vuorinen A, Kauppila S, Knight JA, Glendon G, Mulligan AM, Tollenaar RA, Seynaeve CM, Kriege M, Hooning MJ, van den Ouweland AM, van Deurzen CH, Lu W, Gao YT, Cai H, Balasubramanian SP, Cross SS, Reed MW, Signorello L, Cai Q, Shah M, Miao H, Chan CW, Chia KS, Jakubowska A, Jaworska K, Durda K, Hsiung CN, Wu PE, Yu JC, Ashworth A, Jones M, Tessier DC, González Neira A, Pita G, Alonso MR, Vincent D, Bacot F, Ambrosone CB, Bandera EV, John EM, Chen GK, Hu JJ, Rodriguez Gil JL, Bernstein L, Press MF, Ziegler RG, Millikan RM, Deming Halverson SL, Nyante S, Ingles SA, Waisfisz Q, Tsimiklis H, Makalic E, Schmidt D, Bui M, Gibson L, Müller Myhsok B, Schmutzler RK, Hein R, Dahmen N, Beckmann L, Aaltonen K, Czene K, Irwanto A, Liu J, Turnbull C, Familial Breast Cancer Study, Rahman N, Meijers Heijboer H, Uitterlinden AG, Rivadeneira F, Australian Breast Cancer Tissue Bank Investigators, Olswold C, Slager S, Pilarski R, Ademuyiwa F, Konstantopoulou I, Martin NG, Montgomery GW, Slamon DJ, Rauh C, Lux MP, Jud SM, Bruning T, Weaver J, Sharma P, Pathak H, Tapper W, Gerty S, Durcan L, Trichopoulos D, Tumino R, Peeters PH, Kaaks R, Canzian F, Weiderpass E, Johansson M, Khaw KT, Travis R, Clavel Chapelon F, Kolonel LN, Chen C, Beck A, Hankinson SE, Berg CD, Hoover RN, Lissowska J, Figueroa JD, Chasman DI, Gaudet MM, Diver WR, Willett WC, Hunter DJ, Simard J, Benitez J, Dunning AM, Sherman ME, Chenevix Trench G, Chanock SJ, Hall P, Pharoah PD, Vachon C, Easton DF, Haiman CA, Kraft P., BAGLIETTO, LAURA, CAMPA, DANIELE
المساهمون:	Garcia Closas, M, Couch, Fj, Lindstrom, S, Michailidou, K, Schmidt, Mk, Brook, Mn, Orr, N, Rhie, Sk, Riboli, E, Feigelson, H, Le Marchand, L, Buring, Je, Eccles, D, Miron, P, Fasching, Pa, Brauch, H, Chang Claude, J, Carpenter, J, Godwin, Ak, Nevanlinna, H, Giles, Gg, Cox, A, Hopper, Jl, Bolla, Mk, Wang, Q, Dennis, J, Dicks, E, Howat, Wj, Schoof, N, Bojesen, Se, Lambrechts, D, Broeks, A, Andrulis, Il, Guénel, P, Burwinkel, B, Sawyer, Ej, Hollestelle, A, Fletcher, O, Winqvist, R, Brenner, H, Mannermaa, A, Hamann, U, Meindl, A, Lindblom, A, Zheng, W, Devillee, P, Goldberg, M, Lubinski, J, Kristensen, V, Swerdlow, A, Anton Culver, H, Dörk, T, Muir, K, Matsuo, K, Wu, Ah, Radice, P, Teo, Sh, Shu, Xo, Blot, W, Kang, D, Hartman, M, Sangrajrang, S, Shen, Cy, Southey, Mc, Park, Dj, Hammet, F, Stone, J, Veer, Lj, Rutgers, Ej, Lophatananon, A, Stewart Brown, S, Siriwanarangsan, P, Peto, J, Schrauder, Mg, Ekici, Ab, Beckmann, Mw, Dos Santos Silva, I, Johnson, N, Warren, H, Tomlinson, I, Kerin, Mj, Miller, N, Marme, F, Schneeweiss, A, Sohn, C, Truong, T, Laurent Puig, P, Kerbrat, P, Nordestgaard, Bg, Nielsen, Sf, Flyger, H, Milne, Rl, Perez, Ji, Menéndez, P, Müller, H, Arndt, V, Stegmaier, C, Lichtner, P, Lochmann, M, Justenhoven, C
سنة النشر:	2013
المجموعة:	ARPI - Archivio della Ricerca dell'Università di Pisa
مصطلحات موضوعية:	breast cancer, cancer invasion, cancer risk, chromosome 1, chromosome 16q, chromosome 1q, chromosome 2p, comparative study, follow up, gene locu, genetic association, genetic susceptibility, human, nucleotide sequence, priority journal, signal transduction, single nucleotide polymorphism
الوصف:	Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P = 2.1 × 10-12 and LGR6, P = 1.4 × 10-8), 2p24.1 (P = 4.6 × 10-8) and 16q12.2 (FTO, P = 4.0 × 10-8), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.
نوع الوثيقة:	article in journal/newspaper
وصف الملف:	STAMPA
اللغة:	English
العلاقة:	info:eu-repo/semantics/altIdentifier/pmid/23535733; info:eu-repo/semantics/altIdentifier/wos/WOS:000316840600009; volume:45; issue:4; firstpage:392; lastpage:398; numberofpages:7; journal:NATURE GENETICS; http://hdl.handle.net/11568/458484Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84875701351
DOI:	10.1038/ng.2561
الإتاحة:	https://doi.org/10.1038/ng.2561Test http://hdl.handle.net/11568/458484Test
حقوق:	info:eu-repo/semantics/restrictedAccess
رقم الانضمام:	edsbas.797EF551
قاعدة البيانات:	BASE

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الوصف
DOI:	10.1038/ng.2561