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1دورية أكاديمية
المؤلفون: Rankin, Andrew, Johnson, Adrienne, Roos, Alison, Kannan, Geoffrey, Knipstein, Jeffrey, Britt, Nicholas, Rosenzweig, Mark, Haberberger, James, Pavlick, Dean, Severson, Eric, Vergilio, Jo-Anne, Squillace, Rachel, Erlich, Rachel, Sathyan, Pratheesh, Cramer, Stuart, Kram, David, Ross, Jeffrey, Miller, Vince, Reddy, Prasanth, Alexander, Brian, Ali, Siraj M., Ramkissoon, Shakti
المصدر: The Oncologist ; volume 26, issue 1, page e153-e163 ; ISSN 1083-7159 1549-490X
مصطلحات موضوعية: Cancer Research, Oncology
الوصف: RAF family protein kinases signal through the MAPK pathway to orchestrate cellular proliferation, survival, and transformation. Identifying BRAF alterations in pediatric cancers is critically important as therapeutic agents targeting BRAF or MEK may be incorporated into the clinical management of these patients. In this study, we performed comprehensive genomic profiling on 3,633 pediatric cancer samples and identified a cohort of 221 (6.1%) cases with known or novel alterations in BRAF or RAF1 detected in extracranial solid tumors, brain tumors, or hematological malignancies. Eighty percent (176/221) of these tumors had a known-activating short variant (98, 55.7%), fusion (72, 40.9%), or insertion/deletion (6, 3.4%). Among BRAF altered cancers, the most common tumor types were brain tumors (74.4%), solid tumors (10.8%), hematological malignancies (9.1%), sarcomas (3.4%), and extracranial embryonal tumors (2.3%). RAF1 fusions containing intact RAF1 kinase domain (encoded by exons 10–17) were identified in seven tumors, including two novel fusions TMF1-RAF1 and SOX6-RAF1. Additionally, we highlight a subset of patients with brain tumor with positive clinical response to BRAF inhibitors, demonstrating the rationale for incorporating precision medicine into pediatric oncology. Implications for Practice Precision medicine has not yet gained a strong foothold in pediatric cancers. This study describes the landscape of BRAF and RAF1 genomic alterations across a diverse spectrum of pediatric cancers, primarily brain tumors, but also encompassing melanoma, sarcoma, several types of hematologic malignancy, and others. Given the availability of multiple U.S. Food and Drug Administration-approved BRAF inhibitors, identification of these alterations may assist with treatment decision making, as described here in three cases of pediatric cancer.
الإتاحة: https://doi.org/10.1002/onco.13519Test
https://academic.oup.com/oncolo/article-pdf/26/1/e153/41923561/oncolo_26_1_e153.pdfTest -
2دورية أكاديمية
المؤلفون: Mueller, Sabine, Kline, Cassie, Kilburn, Lindsay, Liang, Winnie S, Jain, Payal, Gupta, Nalin, Panditharatna, Eshini, Nazemi, Kellie, Magge, Suresh N, Crawford, John, Banerjee, Anu, Packer, Roger, Roos, Alison, Zhang, Bo, Zhu, Yuankun, Aboian, Mariam, Tamrazi, Benita, Philips, Joanna, Solomon, David, Molinaro, Annette, Kuhn, John, Byron, Sara A, Nazarian, Javad, Resnick, Adam, Berens, Michael, Prados, Michael
المصدر: Neuro-Oncology ; volume 21, issue Supplement_2, page ii71-ii71 ; ISSN 1522-8517 1523-5866
مصطلحات موضوعية: Cancer Research, Neurology (clinical), Oncology
الإتاحة: https://doi.org/10.1093/neuonc/noz036.036Test
http://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_2/ii71/28443084/noz036.036.pdfTest -
3دورية أكاديمية
المؤلفون: Jain, Payal, Mueller, Sabine, Liang, Winnie S, Panditharatna, Eshini, Zhang, Bo, Zhu, Yuankun, Kambhampati, Madhuri, Kline, Cassie, Kilburn, Lindsay, Gupta, Nalin, Yang, Xiaodong, Nazemi, Kellie, Magge, Suresh N, Crawford, John, Banerjee, Anu, Packer, Roger J, Roos, Alison, Philips, Joanna, Solomon, David, Molinaro, Annette, Yadavili, Sridevi, Kuhn, John, Byron, Sara A, Prados, Michael, Nazarian, Javad, Berens, Michael, Resnick, Adam C
المصدر: Neuro-Oncology ; volume 21, issue Supplement_2, page ii85-ii85 ; ISSN 1522-8517 1523-5866
مصطلحات موضوعية: Cancer Research, Neurology (clinical), Oncology
الإتاحة: https://doi.org/10.1093/neuonc/noz036.089Test
http://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_2/ii85/28443130/noz036.089.pdfTest -
4دورية أكاديمية
المؤلفون: Mueller, Sabine, Liang, Winnie, Gupta, Nalin, Magge, Suresh, Kilburn, Lindsay, Crawford, John, Banerjee, Anu, Nazemi, Kellie, Packer, Roger, Petritsch, Claudia, Truffaux, Nathalene, Roos, Alison, Nicolaides, Theodore, Craig, David, Carpten, John, Byron, Sara, Kuhn, John, Resnick, Adam, Berens, Michael, Prados, Michael, Nazarian, Javad
المصدر: Neuro-Oncology ; volume 19, issue suppl_4, page iv14-iv14 ; ISSN 1522-8517 1523-5866
مصطلحات موضوعية: Cancer Research, Neurology (clinical), Oncology
الإتاحة: https://doi.org/10.1093/neuonc/nox083.055Test
http://academic.oup.com/neuro-oncology/article-pdf/19/suppl_4/iv14/17642770/nox083.055.pdfTest -
5دورية أكاديمية
المؤلفون: Roos, Alison, Ding, Zonghui, Loftus, Joseph C., Tran, Nhan L.
المصدر: Frontiers in Oncology ; volume 7 ; ISSN 2234-943X
مصطلحات موضوعية: Cancer Research, Oncology
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6دورية أكاديمية
المؤلفون: Roos, Alison, Mayo, Zachary, Sonnemann, Heather, Lambert, Gil, Dhruv, Harshil, Winkles, Jeffrey, Berens, Michael, Tran, Nhan, Sabir, Marya
المصدر: Neuro-Oncology ; volume 18, issue suppl_6, page vi45-vi46 ; ISSN 1522-8517 1523-5866
مصطلحات موضوعية: Cancer Research, Neurology (clinical), Oncology
الإتاحة: https://doi.org/10.1093/neuonc/now212.185Test
http://academic.oup.com/neuro-oncology/article-pdf/18/suppl_6/vi45/9645386/now212.185.pdfTest -
7دورية أكاديمية
المؤلفون: Roos, Alison, Satterfield, Laura, Zhao, Shuying, Fuja, Daniel, Shuck, Ryan, Hicks, M John, Donehower, Lawrence A, Yustein, Jason T
المصدر: British Journal of Cancer ; volume 113, issue 9, page 1289-1297 ; ISSN 0007-0920 1532-1827
مصطلحات موضوعية: Cancer Research, Oncology
الإتاحة: https://doi.org/10.1038/bjc.2015.305Test
http://www.nature.com/articles/bjc2015305.pdfTest
http://www.nature.com/articles/bjc2015305Test -
8دورية أكاديمية
المؤلفون: Roos, Alison, Mayo, Zach, Pineda, Michael, Winkles, Jeffrey A., Berens, Michael E., Tran, Nhan L.
المصدر: Neuro-Oncology ; volume 17, issue suppl 5, page v68.3-v68 ; ISSN 1522-8517 1523-5866
مصطلحات موضوعية: Cancer Research, Neurology (clinical), Oncology
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9دورية أكاديمية
المؤلفون: Dhruv, Harshil D., Roos, Alison, Tomboc, Patrick J., Tuncali, Serdar, Chavez, Ashley, Mathews, Ian, Berens, Michael E., Loftus, Joseph C., Tran, Nhan L.
المساهمون: National Cancer Institute, National Institute of Neurological Disorders and Stroke, Ben and Catherine Ivy Foundation
المصدر: Journal of Neuro-Oncology ; volume 126, issue 3, page 397-404 ; ISSN 0167-594X 1573-7373
مصطلحات موضوعية: Cancer Research, Neurology (clinical), Neurology, Oncology